Novel combined index of cardiometabolic risk related to periarterial fat improves the clinical prediction for coronary artery disease complexity

Haberka, Maciej; Lelek, Michał; Bochenek, Tomasz; Kowalówka, Adam; Młynarski, Rafal; Mizia-Stec, Katarzyna; Gąsior, Zbigniew

doi:10.1016/j.atherosclerosis.2017.09.015

Cited by 7 publications

(8 citation statements)

References 39 publications

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“…complex CAD in high and very high cardiovascu lar risk patients. 44 In obese patients, perivascu lar adipose tissue assessed by the carotid extra media thickness was associated with a number of cardiovascular risk factors, and more impor tantly, with abdominal visceral fat. 17 Potential mechanism It was demonstrated that GLP 1R and GLP 2R expression in EF were ele vated in patients with CAD when compared with healthy controls.…”

Section: Glucagon -Like Peptides Receptors and Other Fat Depotsmentioning

confidence: 99%

Epicardial, pericardial fat and glucagon-like peptide-1 and 2 receptors expression in stable patients with multivessel coronary artery disease: an association with renin-angiotensin-aldosterone

Haberka¹,

Siniarski²,

Gajos³

et al. 2021

Polish Archives of Internal Medicine

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GLP -1 and -2 receptors and the renin -angiotensin -aldosterone system 233 an increased volume of EF and a dysfunctional profile of gene expression in this fat depot. 4 More over, major differences were found in the gene expression of inflammatory markers in both EF and pericardial fat (PF) depots. 4 The glucagon like peptide 1 (GLP 1) is an incretin hormone with a spectrum of pharmacological and meta bolic effects: an increase in glucose dependent INTROduCTION Epicardial fat (EF) is a visceral adipose tissue depot surrounding coronary ar teries that has the unique embryology, anato my, and functionality. 1 The increased volume of EF was found to be a risk factor for cardiovascu lar diseases. 2,3 As we described previously, among patients with advanced coronary artery disease (CAD), type 2 diabetes (T2D) was associated with

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Section: Glucagon -Like Peptides Receptors and Other Fat Depotsmentioning

confidence: 99%

Epicardial, pericardial fat and glucagon-like peptide-1 and 2 receptors expression in stable patients with multivessel coronary artery disease: an association with renin-angiotensin-aldosterone

Haberka¹,

Siniarski²,

Gajos³

et al. 2021

Polish Archives of Internal Medicine

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“…Haberka et al (2019) reported that EMT is an independent and strong predictor of significant internal carotid artery stenosis instead of obesity measurements. In addition, the combination of ultrasound indexes related to PVAT and the vascular wall was associated with more complex atherosclerotic coronary artery disease (CAD) in patients with high risk (Haberka et al, 2018). Carotid EMT is a promising index for early assessment of the clinical risk of atherosclerosis (Skilton, 2019).…”

Section: Imaging Features Of Pvat Ultrasoundmentioning

confidence: 99%

Perivascular Adipose Tissue as an Indication, Contributor to, and Therapeutic Target for Atherosclerosis

et al. 2020

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Perivascular adipose tissue (PVAT) has been identified to have significant endocrine and paracrine functions, such as releasing bioactive adipokines, cytokines, and chemokines, rather than a non-physiological structural tissue. Considering the contiguity with the vascular wall, PVAT could play a crucial role in the pathogenic microenvironment of atherosclerosis. Growing clinical evidence has shown an association between PVAT and atherosclerosis. Moreover, based on computed tomography, the fat attenuation index of PVAT was verified as an indication of vulnerable atherosclerotic plaques. Under pathological conditions, such as obesity and diabetes, PVAT shows a proatherogenic phenotype by increasing the release of factors that induce endothelial dysfunction and inflammatory cell infiltration, thus contributing to atherosclerosis. Growing animal and human studies have investigated the mechanism of the above process, which has yet to be fully elucidated. Furthermore, traditional treatments for atherosclerosis have been proven to act on PVAT, and we found several studies focused on novel drugs that target PVAT for the prevention of atherosclerosis. Emerging as an indication, contributor to, and therapeutic target for atherosclerosis, PVAT warrants further investigation.

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“…Of note, there is a scarce publication focused on the prognostic impact of carotid plaque and post-ACS mortality. 33,34 Although CIMT is the most commonly used surrogate marker for atherosclerosis in general population without previous CHD, the presence of carotid plaque can have added to CIMT more power for stratifying patients with very high CV risk, 48 including post-ACS.…”

Section: Limitationsmentioning

confidence: 99%

Prognostic value of carotid intima‐media in the short‐ and long‐term mortality in the Strategy of Registry of Acute Coronary Syndrome (ERICO) study

et al. 2018

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Novel combined index of cardiometabolic risk related to periarterial fat improves the clinical prediction for coronary artery disease complexity

Cited by 7 publications

References 39 publications

Epicardial, pericardial fat and glucagon-like peptide-1 and 2 receptors expression in stable patients with multivessel coronary artery disease: an association with renin-angiotensin-aldosterone

Epicardial, pericardial fat and glucagon-like peptide-1 and 2 receptors expression in stable patients with multivessel coronary artery disease: an association with renin-angiotensin-aldosterone

Perivascular Adipose Tissue as an Indication, Contributor to, and Therapeutic Target for Atherosclerosis

Prognostic value of carotid intima‐media in the short‐ and long‐term mortality in the Strategy of Registry of Acute Coronary Syndrome (ERICO) study

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