Epicardial, pericardial fat and glucagon-like peptide-1 and 2 receptors expression in stable patients with multivessel coronary artery disease: an association with renin-angiotensin-aldosterone

Abstract

GLP -1 and -2 receptors and the renin -angiotensin -aldosterone system 233 an increased volume of EF and a dysfunctional profile of gene expression in this fat depot. 4 More over, major differences were found in the gene expression of inflammatory markers in both EF and pericardial fat (PF) depots. 4 The glucagon like peptide 1 (GLP 1) is an incretin hormone with a spectrum of pharmacological and meta bolic effects: an increase in glucose dependent INTROduCTION Epicardial fat (EF) is a visceral adipose tissue depot surrounding coronary ar teries that has the unique embryology, anato my, and functionality. 1 The increased volume of EF was found to be a risk factor for cardiovascu lar diseases. 2,3 As we described previously, among patients with advanced coronary artery disease (CAD), type 2 diabetes (T2D) was associated with

Systematic investigation of the underlying mechanisms of GLP-1 receptor agonists to prevent myocardial infarction in patients with type 2 diabetes mellitus using network pharmacology

“…Angiotensinogen undergoes two cleavages to form angiotensin II (Ang II), which has well-known adverse effects on the myocardium. A recent study showed that the mRNA expression of GLP-1R was considerably associated with the components of the renin-angiotensin-aldosterone system (RAAS) detected in epicardial and pericardial fat in patients with severe coronary artery disease ( Haberka et al, 2021 ). However, the interactive regulation between GLP-1R and the RAAS is still unclear.…”

The Relationship of Epicardial Adipose Tissue and Cardiovascular Disease in Chronic Kidney Disease and Hemodialysis Patients

“…In addition, the study showing that angiotensin converting enzyme hyperactivity in human EAT is associated with cardiac dysfunction supports these data [ 50 ]. Another mechanism revealed in recent years is that people with a history of CVD have a higher expression of glucagon-like peptide (GLP) in EAT [ 51 ]. Studies revealing the relationship between RAS activity and EAT CVD in CKD patients are insufficient in the literature.…”

The cardiometabolic predictive value of anthropometric parameters, vascular ultrasound indexes and fat depots among patients with high cardiovascular risk: an 8-year prospective cohort study

“…The ultrasound indexes were performed as described before [4,5,17]. Briefly, all the ultrasound images and video clips were provided by one experienced physician using constant and standardized settings.…”