Prognostic value of carotid intima‐media in the short‐ and long‐term mortality in the Strategy of Registry of Acute Coronary Syndrome (ERICO) study

Meireles, Danilo Peron; Santos, Itamar S; Alencar, Airlane Pereira; Lotufo, Paulo A; Goulart, Alessandra Carvalho

doi:10.1111/echo.14044

“…In our study, the common carotid segment was assessed, yielding lack of prognostic significance. [11].…”

Section: Discussionmentioning

confidence: 99%

“…aiming at evaluating mortality associated to CIMT in the participants from the Strategy of Registry of Acute Coronary Syndrome (ERICO) study. Despite the association between crude mortality rates and high CIMT values, this effect was no longer significant after adjusting for age [11].…”

Section: Discussionmentioning

confidence: 99%

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Non-invasive vascular measures as prognostic predictors for older patients with non-ST elevation acute coronary syndrome

Dirjayanto,

Pompei,

Rubino

et al. 2024

Coronary Artery Disease

1

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Background Adverse cardiac events are common in older patients with non-ST elevation acute coronary syndrome (NSTEACS), yet prognostic predictors are still lacking. This study investigated the long-term prognostic significance of non-invasive measures including endothelial function, carotid intima-media thickness (CIMT), and vascular stiffness in older NSTEACS patients referred for invasive treatment. Methods NSTEACS patients aged 75 years and older recruited to a multicentre cohort study (NCT01933581) were assessed for baseline endothelial function using endoPAT logarithm of reactive hyperemia index (LnRHI), CIMT using B-mode ultrasound, and vascular stiffness using carotid-femoral pulse wave velocity (cfPWV). Long-term outcomes included major adverse cardiovascular events (MACE), a composite of death, reinfarction, urgent revascularization, stroke/transient ischemic attack, and significant bleeding. Results Recruitment resulted in 214 patients assessed for LnRHI, 190 patients assessed for CIMT and 245 patients assessed for cfPWV. For LnRHI group (median follow-up 4.73 years [IQR: 1.41–5.00]), Cox regression analysis revealed a trend towards increased risk of MACE (HR: 1.24 [95% CI: 0.80–1.93]; P = 0.328) and mortality (HR: 1.49 [95% CI: 0.86–2.59]; P = 0.157), but no significance was reached. No difference for other components of MACE was found. For CIMT group (median follow up 4.74 years [IQR: 1.55–5.00]), no statistically significant difference in MACE was found (HR: 0.92 [95% CI: 0.53–1.59]; P = 0.754). Similarly, for cfPWV group (median follow-up 4.96 years [IQR: 1.55–5.00]), results did not support prognostic significance (for MACE, HR: 0.95 [95% CI: 0.65–1.39]; P = 0.794). Conclusion Endothelial function, CIMT and vascular stiffness were proven unsuitable as strong prognostic predictors in older patients with NSTEACS. Clinical trial registration: NCT01933581.

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“…As a good marker of insulin resistance, the TyG index is associated with an increased risk of diabetes mellitus [8], stroke [9], coronary artery disease [10,11] in healthy individuals. It is bene cial for estimating the risk of adverse prognosis of symptomatic and asymptomatic coronary artery disease and acute myocardial infarction [12][13][14]. In addition, there is evidence that the TyG index is also correlated with asymptomatic carotid artery atherosclerosis [15].…”

Section: Introductionmentioning

confidence: 99%

Triglyceride Glucose Index Is Independently Associated With Aorta Intima-Media Thickness In Patients Without Clinical Manifestations of Cardiovascular Disease

Özbiçer

¹

,

Yüksel

²

,

Urgun

³

2022

Preprint

1

0

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Background and Aims: Subclinical atherosclerosis begins to develop in the thoracic aorta early in life. Insulin resistance is a well-established risk factor for the development of atherosclerosis. The triglyceride-glucose (TyG) index is a reliable marker of insulin resistance regardless of glucose tolerance or obesity. We aimed to investigate the relationship between the TyG index and aortic intima-media thickness (IMT) in patients without diabetes mellitus and cardiovascular disease undergoing transesophageal echocardiography due to suspected structural heart disease.Methods: One hundred twenty-two patients enrolled in the study between January 2021 and June 2021. Triglyceride-glucose index was calculated using fasting laboratory parameters, major cardiovascular risk factors and IMT of the thoracic aorta were recorded. Patients were divided into two groups according to their median IMT; patients with an IMT equal to or less than 1.42 mm were low IMT group, and higher than 1.42 mm were high IMT group.Results: Triglyceride-glucose index were higher in the high IMT group (8.69 ± 0.59 vs. 8.37 ± 0.53, p= 0.003). Triglyceride-glucose index was correlated with IMT (r=0.259, p=0.005) and in binary logistic regression analysis age and TyG was independently associated with having high IMT (β = 0.091, exp(B)=1.095 95%CI = 1.041 – 1.152, p<0.001 and β=1.726, exp(B)= 5.621 95%CI= 1.139- 27.728, p=0.034, respectively)Conclusion: We found an independent relationship between TyG and IMT of the thoracic aorta, an early marker of subclinical atherosclerosis in patients without atherosclerotic cardiovascular disease. Therefore, the TyG index can be used to identify high-risk subjects among healthy subjects.

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“…As a good marker of insulin resistance, the TyG index is associated with an increased risk of diabetes mellitus [8], stroke [9], coronary artery disease [10,11] in healthy individuals. It is bene cial for estimating the risk of adverse prognosis of symptomatic and asymptomatic coronary artery disease and acute myocardial infarction [12][13][14]. In addition, there is evidence that the TyG index is also correlated with asymptomatic carotid artery atherosclerosis [15].…”

Section: Introductionmentioning

confidence: 99%

Triglyceride Glucose Index is Independently Associated with Aorta Intima-Media Thickness in Patients without Clinical Manifestations of Cardiovascular Disease Running Head: Triglyceride Glucose Index and Intima-Media Thickness

Özbiçer

¹

,

Yüksel

²

,

Urgun

³

2022

Preprint

0

View full text Add to dashboard Cite

Background and Aims: Subclinical atherosclerosis begins to develop in the thoracic aorta early in life. Insulin resistance is a well-established risk factor for the development of atherosclerosis. The triglyceride-glucose (TyG) index is a reliable marker of insulin resistance regardless of glucose tolerance or obesity. We aimed to investigate the relationship between the TyG index and aortic intima-media thickness (IMT) in patients without diabetes mellitus and cardiovascular disease undergoing transesophageal echocardiography due to suspected structural heart disease.Methods: One hundred twenty-two patients enrolled in the study between January 2021 and June 2021. Triglyceride-glucose index was calculated using fasting laboratory parameters, major cardiovascular risk factors and IMT of the thoracic aorta were recorded. Patients were divided into two groups according to their median IMT; patients with an IMT equal to or less than 1.42 mm were low IMT group, and higher than 1.42 mm were high IMT group.Results: Triglyceride-glucose index were higher in the high IMT group (8.69 ± 0.59 vs. 8.37 ± 0.53, p= 0.003). Triglyceride-glucose index was correlated with IMT (r=0.259, p=0.005) and in binary logistic regression analysis age and TyG was independently associated with having high IMT (β = 0.091, exp(B)=1.095 95%CI = 1.041 – 1.152, p<0.001 and β=1.726, exp(B)= 5.621 95%CI= 1.139- 27.728, p=0.034, respectively)Conclusion: We found an independent relationship between TyG and IMT of the thoracic aorta, an early marker of subclinical atherosclerosis in patients without atherosclerotic cardiovascular disease. Therefore, the TyG index can be used to identify high-risk subjects among healthy subjects.

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Prognostic value of carotid intima‐media in the short‐ and long‐term mortality in the Strategy of Registry of Acute Coronary Syndrome (ERICO) study

Abstract: Carotid intima media thickness was mainly influenced by aging. CIMT was not a good predictor of all-cause, CVD or CHD mortality in the ERICO study.

Cited by 4 publications

References 45 publications

Non-invasive vascular measures as prognostic predictors for older patients with non-ST elevation acute coronary syndrome

Non-invasive vascular measures as prognostic predictors for older patients with non-ST elevation acute coronary syndrome

Triglyceride Glucose Index Is Independently Associated With Aorta Intima-Media Thickness In Patients Without Clinical Manifestations of Cardiovascular Disease

Triglyceride Glucose Index is Independently Associated with Aorta Intima-Media Thickness in Patients without Clinical Manifestations of Cardiovascular Disease Running Head: Triglyceride Glucose Index and Intima-Media Thickness

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