Novel chelate-setting calcium-phosphate cements fabricated with wet-synthesized hydroxyapatite powder

Abstract

The hydroxyapatite (HAp) powder preparation process was optimized to fabricate inositol phosphate-HAp (IP6-HAp) cement with enhanced mechanical properties. Starting HAp powders were synthesized via a wet chemical process. The effect of the powder preparation process on the morphology, crystallinity, median particle size, and specific surface area (SSA) of the cement powders was examined, together with the mechanical properties of the resulting cement specimens. The smallest crystallite and median particle sizes, and the highest SSA were obtained from ball-milling of as-synthesized HAp powder under wet conditions and then freeze-drying. IP6-HAp cement fabricated with this powder had a maximum compressive strength of 23.1 ± 2.1 MPa. In vivo histological studies using rabbit models revealed that the IP6-HAp cements were directly in contact with newly formed and host bones. Thus, the present chelate-setting HAp cement is promising for application as a novel paste-like artificial bone.

Effect of phytic acid on the setting times and tensile strengths of calcium silicate‐based cements

“…The efficacy of phytic acid can also be explained by its high content of negatively charged phosphate groups that strongly bind to metallic cations, such as calcium, within the cements (27). Previous studies that utilised phytic acid to develop novel calcium-phosphate cements (CPCs) have confirmed that the setting mechanism is based on the chelative properties of phytic acid (14,15). These studies also indicated that the newly developed CPCs are biocompatible and osteoconductive (14,15).…”

“…Here the setting time of MTA and Biodentine ® significantly decreased when the materials were mixed with 1% phytic acid. Previous studies that utilised phytic acid to develop novel calcium-phosphate cements (CPCs) have confirmed that the setting mechanism is based on the chelative properties of phytic acid (14,15). The highly hydrophilic nature of phytic acid may have contributed to this finding (10) because calcium silicate-based cements set through a hydration reaction that is mediated by their hydrophilic particles (6).…”

“…Thus, the null hypothesis has to be partially rejected because the addition of phytic acid significantly affected the setting time. These studies also indicated that the newly developed CPCs are biocompatible and osteoconductive (14,15). The efficacy of phytic acid can also be explained by its high content of negatively charged phosphate groups that strongly bind to metallic cations, such as calcium, within the cements (27).…”

Antibacterial polyetheretherketone implants immobilized with silver ions based on chelate-bonding ability of inositol phosphate: Processing, material characterization, cytotoxicity, and antibacterial properties

“…One of the present authors and his coworkers successfully developed a novel calcium phosphate cement (CPC) using inositol hexaphosphate [C 6 H 6 (OPO 3 H 2 ) 6 ; IP6] as a chelating agent . IP6 is present in grains of wheat, rice, and soybean; thus, it has a strong chelating capacity for Ca 2+ ions, similarly to ethylenediaminetetraacetic acid (EDTA).…”

“…19 One of the present authors and his coworkers successfully developed a novel calcium phosphate cement (CPC) using inositol hexaphosphate [C 6 H 6 (OPO 3 H 2 ) 6 ; IP6] as a chelating agent. [20][21][22][23][24] IP6 is present in grains of wheat, rice, and soybean 25 ; thus, it has a strong chelating capacity for Ca 21 ions, similarly to ethylenediaminetetraacetic acid (EDTA). The paste containing HAp particles surface-modified with IP6 and pure water set to form a cement specimen based on chelate-bonding of IP6 among individual Ca 21 ions in HAp particles.…”