Antibacterial polyetheretherketone implants immobilized with silver ions based on chelate-bonding ability of inositol phosphate: Processing, material characterization, cytotoxicity, and antibacterial properties

Kakinuma, Hiroaki; Ishii, Ken; Ishihama, Hiroko; Honda, Michiyo; Toyama, Yoshiaki; Matsumoto, Morio; Aizawa, Mamoru

doi:10.1002/jbm.a.35157

Cited by 42 publications

(35 citation statements)

References 34 publications

(84 reference statements)

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“…While changing surface chemistry and introducing roughness seem to provide synergistic effects for osteogenesis, the creation of pores and sulfur‐containing groups by sulfonation does not have the same effect. Surface‐porous PEEK prepared by sulfonation promoted apatite formation in 1x and 1.5x SBF; however, its acidic surface reduces the pH to about 2 . While apatite formation was desirable for osseointegration, the low pH environment induced toxicity that negatively impacted cell viability, proliferation, and in vivo bone formation .…”

Section: Strategies For Improving Osseointegrationmentioning

confidence: 99%

Surface Modification Strategies to Improve the Osseointegration of Poly(etheretherketone) and Its Composites

Buck

Cerruti

2019

Macromolecular Bioscience

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In the last 5 years, a wide variety of surface modification strategies are explored to improve the integration of poly(etheretherketone) (PEEK) implants with bone. Since PEEK does not support bone on‐growth, its surface properties need to be tailored to promote osteogenesis at the bone‐implant interface. Surface modifications applied to achieve this response range from simple surface morphology changes to the deposition of osteoconductive coatings. Of the many methods, titanium and/or hydroxyapatite coatings, extrusion to create surface pores, and an accelerated neutral atom beam treatment have been approved by the U.S. Food and Drug Administration to improve the integration of PEEK spinal cages. The success of these surface modifications brings hope for the clinical translation of other techniques in the future, but there are several limitations that may be preventing other treatments from reaching the clinic. This review describes numerous strategies that have been applied to PEEK‐based implants for improving their osseointegration and enhancing their antibacterial properties. The review concludes with a discussion about future directions for the field and provides suggestions for advancing clinical translation of surface‐modified PEEK implants to improve the lives of patients in need of these implants.

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Section: Strategies For Improving Osseointegrationmentioning

confidence: 99%

Surface Modification Strategies to Improve the Osseointegration of Poly(etheretherketone) and Its Composites

Buck

Cerruti

2019

Macromolecular Bioscience

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“…Stoichiometric amounts of silver nitrate in different concentrations were available in a glass reactor previously washed with sulfochromic solution. Subsequently a NaOH dissolution (0.5 mol/L) was added to the above solutions producing silver monoxide, as shown in Equation (1) [23,24].…”

Section: Synthesis Of Silver Nanoparticles and Coating Of Polyetheretmentioning

confidence: 99%

“…Currently, bacterial growth is the main problem of air purification systems such as heaters, air-conditioning and ventilators that are used indoors [1,2]. Some microorganisms are adhered to and absorbed by the parts of the air purifying systems which return to the environment under operational conditions, spreading pathogenic bacteria not only to humans but also to plants and animals [3].…”

Section: Introductionmentioning

confidence: 99%

Coating of Polyetheretherketone Films with Silver Nanoparticles by a Simple Chemical Reduction Method and Their Antibacterial Activity

et al. 2019

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The coating of polymeric substrate polyetheretherketone (PEEK) with silver nanoparticles (AgNPs) was carried out by a wet chemical route at room temperature. The coating process was developed from the Tollens reagent and D-glucose as reducing agent. The resulting composite exhibited antimicrobial activity. The PEEK films were coated with a single layer and two layers of silver nanoparticles in various concentrations. The crystallographic properties of the polymer and the silver nanoparticles were analyzed by X-ray diffraction (XRD). Fourier transform infrared spectra (FTIR) show the interaction between the silver nanoparticles with the polymeric substrate. Transmission electron microscope (TEM) images confirmed the obtaining of metallic nanoparticles with average sizes of 25 nm. It was possible to estimate the amount of silver deposited on PEEK with the help of thermogravimetric analysis. The morphology and shape of the AgNPs uniformly deposited on the PEEK films was ascertained by the techniques of scanning electron microscopy (SEM) and atomic force microscopy (AFM), evidencing the increase in the amount of silver by increasing the concentration of the metal precursor. Finally, the antibacterial activity of the films coated with Ag in Escherichia coli, Serratia marcescens and Bacillus licheniformis was evaluated, evidencing that the concentration of silver is crucial in the cellular replication of the bacteria.

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“…12,14 Some studies have suggested that PEEK materials are relatively resistant to microbial adhesion and hence associated with lower infection rates than their titanium counterparts. 15 Continuously, its minimal radiographic signature allows optimal evaluation of bony fusion on plain radiographs and computed tomography (Figure 2). There is also no risk of metal allergy.…”

Section: Polyetheretherketone Cagesmentioning

confidence: 99%

Towards the optimum spinal fusion device

Gorenšek¹,

Jenko²,

Kocjančič³

et al. 2018

Mater. Tehnol.

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Spinal interbody fusion (spondylodesis) remains a gold standard for the treatment of instability, deformity and degenerative disease of the spine. Over the past 40 years surgical techniques and implant-device (cage) technology for spinal fusion have changed significantly. Design and materials have evolved with one common goal, to develop suitable implants that would address all three major issues of the procedure: stability, restoration of lordosis and osteointegration. Historically, two main materials have been utilized in the creation of cages: titanium (Ti) and polyetheretherketone (PEEK). The focus of spinal surgeons is constantly shifting from one material to another, because of the aggressive, commercial drive from the industry. The choice of optimal spinal interbody fusion device was always a matter of controversy. Therefore, this article aims to provide an overview of the different materials and designs from the biomechanical and also clinical aspect. A systematic review of the literature was made. The inadequate available clinical trials and lack of comparisons between different models have prevented definitive conclusions; therefore, further prospective randomized studies are necessary in the future to define one cage as a mainstay of clinical practice. Keywords: spondylodesis, cage, titanium, polyetheretherketone Zatrditev hrbteni~nega segmenta (spondilodeza) predstavlja zlati standard zdravljenja nestabilnosti, deformacij in degenerativnih bolezni hrbtenice. V zadnjih 40 letih so se kirur{ka tehnika in umetni medvreten~ni vsadki (kletke) ob~utno spremenili. Oblika in materiali so se razvijali z enim skupnim ciljem, to je odkriti vsadek, ki bi omogo~al stabilnost hrbteni~nega segmenta, vzdr`evanje lordoze ter osteointegracijo. Zgodovinsko gledano sta bila dva najpogosteje uporabljena materiala titan in polietereterketon. Dandanes med hrbteni~nimi kirurgi ostaja nesoglasje glede optimalne izbire umetnega medvreten~nega vsadka. Namen tega~lanka je predstaviti prednosti in slabosti najpogosteje uporabljenih materialov. Na podlagi aktualne strokovne literature je bila opravljena primerjava biomehanskih in klini~nih rezultatov razli~nih vsadkov. Glede na pomanjkljivost naklju~nih prospektivnih multicentri~nih {tudij ostaja izbira optimalnega umetnega hrbteni~nega vsadka {e naprej problemati~na.

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Antibacterial polyetheretherketone implants immobilized with silver ions based on chelate-bonding ability of inositol phosphate: Processing, material characterization, cytotoxicity, and antibacterial properties

Cited by 42 publications

References 34 publications

Surface Modification Strategies to Improve the Osseointegration of Poly(etheretherketone) and Its Composites

Surface Modification Strategies to Improve the Osseointegration of Poly(etheretherketone) and Its Composites

Coating of Polyetheretherketone Films with Silver Nanoparticles by a Simple Chemical Reduction Method and Their Antibacterial Activity

Towards the optimum spinal fusion device

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