Novel Blend Scaffolds from Poly(caprolactone)Chitosan-Poly(vinyl alcohol): Physical, Morphological and Biological Studies

Gholipour-Kanani, Adeleh; Bahrami, S. Hajir; Samadikuchaksaraei, Alí

doi:10.1166/jbt.2014.1163

Cited by 10 publications

(20 citation statements)

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“…As the applied voltage overcomes the surface tension of the polymer solution, fibers are drawn which is collected at the grounded collector. The nanofibers obtained from electrospinning technique have diameters in the range 5–500 nm with small pore size and a high surface area, which possessed high impact on biomedical applications such as scaffoldings for damaged blood vessel replacement and cardiac patches . Researchers utilized electrospun polymeric scaffolds from polycaprolactone (PCL) and poly(L‐lactic acid) for the formation of functional cardiac cells layer .…”

Section: Introductionmentioning

confidence: 99%

“…The nanofibers obtained from electrospinning technique have diameters in the range 5-500 nm with small pore size and a high surface area, which possessed high impact on biomedical applications such as scaffoldings for damaged blood vessel replacement and cardiac patches. 6,7 Researchers utilized electrospun polymeric scaffolds from polycaprolactone (PCL) and poly(L-lactic acid) for the formation of functional cardiac cells layer. 1,8 In another research, a functional composite made from PLGA/gelatin using electrospinning was fabricated.…”

Section: Introductionmentioning

confidence: 99%

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Blood compatibility and physicochemical assessment of novel nanocomposite comprising polyurethane and dietary carotino oil for cardiac tissue engineering applications

Jaganathan

Mani

Manikandan

et al. 2017

J of Applied Polymer Sci

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Cardiovascular diseases (CVD) were estimated to claim 17 million lives each year. Among these, coronary heart disease almost accounts 50% deaths associated with CVD, which causes the blockage of the coronary arteries that supplies blood to the heart. Nowadays, the cardiac tissue engineering have become a promising solution to overcome the drawbacks associated with current therapies. Further, the scaffold used in cardiac tissue engineering must possess thromboresistant and anticoagulant nature to serve as a plausible candidate for cardiovascular applications. In this present investigation, a novel nanocomposite based on polyurethane (PU) and carotino oil was fabricated using electrospinning. Scanning electron microscopy images indicated that the nanocomposites have smaller fiber diameter (702 ± 130 nm) compared to the pristine PU (969 ± 217 nm). The Fourier transform infrared spectroscopy analysis confirmed the interaction between the carotino oil and PU by the formation of hydrogen bond and shifting of CH peak. The contact angle of electrospun PU/carotino oil was found to be 119°, which was increased compared to pristine PU (86°) indicating the hydrophobic nature of developed nanocomposites. Moreover, the surface roughness and thermal stability were found to be enhanced due to the presence of carotino oil in the PU matrix indicated in atomic force microscopy and thermogravimetric analysis. The enhanced surface roughness of nanocomposites resulted in delayed activation of the blood clot as revealed in activated partial thromboplastin time and prothrombin time assay. Moreover, the hemolytic index of fabricated nanocomposites was found to very low of about 1.33% compared to pristine PU (2.73%), suggesting non‐hemolytic nature and also better blood compatibility. So, the developed PU/carotino nanocomposites having desirable characteristics like better physicochemical and blood compatibility may render appropriate potentials for raw materials of cardiac tissue engineering. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45691.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Blood compatibility and physicochemical assessment of novel nanocomposite comprising polyurethane and dietary carotino oil for cardiac tissue engineering applications

Jaganathan

Mani

Manikandan

et al. 2017

J of Applied Polymer Sci

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“…The chemical structure of Nano fiber PLA and its favorable biological properties such as its biocompatibility and antibacterial nature cause the assimilation of the biochemical environment of the natural tissue and absorption of fibroblasts as well as facilitating wound healing. The instances of wounds are healed after 10 days (14).…”

Section: Discussionmentioning

confidence: 99%

The Possibility of Diabetic Wound Healing Using Electro spun PLA Nano Fibers

Majd¹,

Khorasgani²,

Mapar³

et al. 2017

JARB

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Diabetes is a metabolic disorder demonstrated by hyperglycemia and is typically resulted from defects in insulin secretion and impaired pancreatic function. In general, wound infection is a common complication of diabetes and finding effective remedies (medications) and methods of diabetic wound healing has recently been of interests of researchers. In the present research study, PLA NANO fiber scaffolds are prepared by electro spinning in two different concentrations of 2% and 4%. Indeed, electron microscopic scanning of this NANO fiber represents the achievement of NANO fibers with average diameter of 190 nm ± 44/4 nm and 460 nm ± 75 nm that encompass a uniform morphology. Given the fact that the PLA NANO fiber scaffolding with concentration of 2% has less average diameter, smaller pores and higher biodegradability, hence, it has been selected to study wound healing. In this study, 18 male Wistar rats weighing 250-280g are divided into three groups. First, two groups of rats become diabetic with streptozotocin (55mg / kg i.p.) and another group is monitored as a control type (healthy rats). After observing the symptoms of diabetes and hyperglycemia (250-300 mg /dl in diabetic group), a wound is made on the back of neck of all four groups with diameter of 1 cm through surgical scissors. Then, wound is treated in the experimental group on a daily basis for 14 days by PLA NANO fiber scaffolding. Meanwhile, macroscopic and microscopic studies are adopted on 0, 4, 7, 14 and 7, 14 days respectively. The results revealed wound size reduction, epidermal gap decrement and reduction in wound treatment area in the treatment group compared to it in healthy groups. This, in turn, implies the positive impact of the NANO fibers in the process of wound healing.

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“…In the present study, Cs: PVA and PCL: Cs: PVA nanofibrous blend scaffolds fabricated in our previous studies [19][20][21][22][23], were used for further investigations on the healing of diabetic wounds. The nanofibrous scaffolds were exposed to excision wounds on diabetic dorsum skin and diabetic foot on rat models (n = 16).…”

Section: Introductionmentioning

confidence: 99%

Effect of novel blend nanofibrous scaffolds on diabetic wounds healing

Gholipour-Kanani

Bahrami

Rabbani

2016

IET nanobiotechnol.

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Chitosan-poly (vinyl alcohol) (Cs: PVA) (2:3) and poly (caprolactone)-chitosan-poly (vinyl alcohol) (PCL: Cs: PVA) (2:1:1.5) nanofibrous blend scaffolds were fabricated using the electrospinning technique in the authors' previous studies. The results of the previous studies confirmed the high biological properties of the scaffolds and their ability in healing of burn and excision wounds on rat model. In the present study, the biological scaffolds were applied on diabetic dorsum skin wounds and diabetic foot wound on rat models (n = 16). Macroscopic and microscopic investigations were carried out using digital images and haematoxylin and eosin (H&E) staining respectively, to measure the wound areas and to track wound healing rate. It was found that at all time points the areas of wounds treated with nanofibrous scaffolds were smaller compared with the controls. Pathological results showed much better healing efficacy for the test samples compared with the control ones. Pathological investigations proved the presence of more pronounced granulation tissues in the scaffold-treated wounds compared with the control ones. At 20 days post excision, the scaffold-treated groups achieved complete repair. The results indicated that Cs: PVA and PCL: Cs: PVA nanofibrous webs could be considered to be promising materials for burn, excision and diabetic wounds healing.

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Novel Blend Scaffolds from Poly(caprolactone)Chitosan-Poly(vinyl alcohol): Physical, Morphological and Biological Studies

Cited by 10 publications

References 0 publications

Blood compatibility and physicochemical assessment of novel nanocomposite comprising polyurethane and dietary carotino oil for cardiac tissue engineering applications

Blood compatibility and physicochemical assessment of novel nanocomposite comprising polyurethane and dietary carotino oil for cardiac tissue engineering applications

The Possibility of Diabetic Wound Healing Using Electro spun PLA Nano Fibers

Effect of novel blend nanofibrous scaffolds on diabetic wounds healing

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