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Background and Objectives: Infectious diseases are among the most known important causes of morbidity and mortality in the world. The ongoing explosion antibiotic-resistant bacteria and side effects of medications, application of assistive methods including the use of medicinal plants for treatment have become particularly important. Materials and Methods: In this study, the ethanol extract of green tea (Camellia sinensis) and yarrow flower (Achillea millefolium) were prepared by maceration method and its antibacterial effect on four clinical strains of antibiotic resistant bacteria including Klebsiella pneumoniae, Acinetobacter, Escherichia coli and Pseudomonas aeruginosa were evaluated with microtiter plate method for determining the MIC (Minimum Inhibitory Concentration). Original Research Article Results: The MICs of green tea extract for mg/ml for Klebsiella pneumoniae, Pseudomonas aeruginosa Achillea millefolium extract for Acinetobacter baumannii against Klebsiella pneumoniae and Conclusion: Considering the antimicrobial effects of green tea and Achillea on four strains of resistant bacteria, the extract of this plant can be used in control and treatment of infections caused by these infectious agents.

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Objective: The healing effects of two different dilutions (5 & 100%) of N-Chromosome Royal Jelly and ANGIPARS ointment were investigated and measured on experimental injuries in streptozotocin (STZ)- induced diabetic rats. This study investigated the healing effects of 2 different N Chromosome Royal Jelly dilutions on injuries of STZ-induced diabetic rats. Materials and Methods: For diabetes induction, male Wistar rats received STZ (55 mg/kg) intraperitoneally and plasma glucose level measurement after 72 hours demonstrated diabetes induction. Rats were randomly divided into 5 groups of 6 members and one square centimeter (cm2 ) wound was surgically induced in the dorsal region of each rat. The test groups were treated with ANGIPARS, undiluted royal jelly N chromosome, and royal jelly N chromosome 5% separately. The control groups were including non-diabetic and untreated diabetic rats. Results: The findings indicate a significant acceleration in wound healing of the diabetic rats treated by ANGIPARS ointment or royal jelly N chromosomes 5%. RJ also shortened the healing period of desquamated skin lesions. Thus, RJ possesses an anti-inflammatory action and is able to augment wound healing, but does not have an insulin-like action in streptozotocin-diabetic rats. Conclusion: Regarding the mentioned findings, royal jelly as a natural product may play an effective role in treating chronic wounds in mice, which makes it a proper candidate for use in human wound repair. Nonetheless, it seems that determination of the suitable dilution of this compound will result in better effects, thus more studies are recommended.

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Diabetes is a metabolic disorder demonstrated by hyperglycemia and is typically resulted from defects in insulin secretion and impaired pancreatic function. In general, wound infection is a common complication of diabetes and finding effective remedies (medications) and methods of diabetic wound healing has recently been of interests of researchers. In the present research study, PLA NANO fiber scaffolds are prepared by electro spinning in two different concentrations of 2% and 4%. Indeed, electron microscopic scanning of this NANO fiber represents the achievement of NANO fibers with average diameter of 190 nm ± 44/4 nm and 460 nm ± 75 nm that encompass a uniform morphology. Given the fact that the PLA NANO fiber scaffolding with concentration of 2% has less average diameter, smaller pores and higher biodegradability, hence, it has been selected to study wound healing. In this study, 18 male Wistar rats weighing 250-280g are divided into three groups. First, two groups of rats become diabetic with streptozotocin (55mg / kg i.p.) and another group is monitored as a control type (healthy rats). After observing the symptoms of diabetes and hyperglycemia (250-300 mg /dl in diabetic group), a wound is made on the back of neck of all four groups with diameter of 1 cm through surgical scissors. Then, wound is treated in the experimental group on a daily basis for 14 days by PLA NANO fiber scaffolding. Meanwhile, macroscopic and microscopic studies are adopted on 0, 4, 7, 14 and 7, 14 days respectively. The results revealed wound size reduction, epidermal gap decrement and reduction in wound treatment area in the treatment group compared to it in healthy groups. This, in turn, implies the positive impact of the NANO fibers in the process of wound healing.