Novel Bioengineered Small Caliber Vascular Graft With Excellent One-Month Patency

Ishii, Yôsuke; Kronengold, Russell T.; Virmani, Renu; Rivera, Elias; Goldman, Scott; Prechtel, Ericka J.; Schuessler, Richard B.; Damiano, Ralph J.

doi:10.1016/j.athoracsur.2006.09.053

Cited by 20 publications

(17 citation statements)

References 22 publications

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“…Despite the variations in mechanical properties, all materials (with perhaps the exception of 12% PEI) retained mechanical properties that would be highly favorable for vascular graft applications. The tensile strength and elastic moduli of native arteries are approximately 1.4 and 1.5-3 MPa, respectively [5,48,49], while the PU-PEI materials described here possessed tensile strengths and moduli of 1.5-6 and 2.5-3 MPa, respectively. In contrast, ePTFE has a tensile strength of 27 MPa and an elastic modulus of 500 MPa, which are orders of magnitude different from the properties of the native vasculature.…”

Section: Discussionmentioning

confidence: 98%

Regulation of polyurethane hemocompatibility and endothelialization by tethered hyaluronic acid oligosaccharides

2009

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Section: Discussionmentioning

confidence: 98%

Regulation of polyurethane hemocompatibility and endothelialization by tethered hyaluronic acid oligosaccharides

2009

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“…Insertion of grafts 3 to 5 mm in diameter in the rabbit generally requires placement in the aortic 39,[136][137][138][139] or aortoiliac 38 position, although sizemismatched conduits up to 5 mm diameter have been placed in the CCA. 148,149 The disadvantage of aortic interposition grafting is the lack of an intra-animal control.…”

Section: Small-animal Models For the Assessment Of Novel Vascular Conmentioning

confidence: 99%

Animal models for the assessment of novel vascular conduits

Byrom

Bannon

White

et al. 2010

Journal of Vascular Surgery

155

132

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The development of an ideal small-diameter conduit for use in vascular bypass surgery has yet to be achieved. The ongoing innovation in biomaterial design generates novel conduits that require preclinical assessment in vivo, and a number of animal models have been used for this purpose. This article examines the rationale behind animal models used in the assessment of small-diameter vascular conduits encompassing the commonly used species: baboons, sheep, pigs, dogs, rabbits, and rodents. Studies on the comparative hematology for these species relative to humans are summarized, and the hydrodynamic values for common implant locations are also compared. The large- and small-animal models are then explored, highlighting the characteristics of each that determine their relative utility in the assessment of vascular conduits. Where possible, the performance of expanded polytetrafluoroethylene is given in each animal and in each location to allow direct comparisons between species. New challenges in animal modeling are outlined for the assessment of tissue-engineered graft designs. Finally, recommendations are given for the selection of animal models for the assessment of future vascular conduits.

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“…To this end, efforts to improve the haemocompatibility of various materials have often concentrated on designing systems to elute anticoagulants, such as heparin [10,11]. Heparin is a naturally occurring glycosaminoglycan (GAG) with antithrombotic properties.…”

Section: Introductionmentioning

confidence: 99%