Novel azo pyridone dyes based on dihydropyrimidinone skeleton: Synthesis, DFT study and anticancer activity

Soft 3D hybrid network for delivery and controlled release of poorly soluble dihydropyrimidinone compound: An insight into the novel system for potential application in leukemia treatment

“…Namely, this compound has manifested cytotoxicity against all assayed cancer cell lines, and moreover, it has been selective in the cytotoxic action between cancer cells K562 and normal lung fibroblasts MRC‐5. The chronic myelogenous leukemia cells K562 have been the most sensitive to the anticancer activity of DHPMP with IC 50 value at concentration of 24.97 μM 18 . Besides, the calculated lipophilicity and pharmacokinetic parameters of DHPMP have satisfied the fundamental drug‐like properties 14 .…”

“…Hydrochloric acid (37%) was supplied from Zorka Pharma (Serbia). The chemicals used for the synthesis of azo compound were purchased from Merck, Fluka and Acros 18 . All chemicals were used as received.…”

“…During the past years, the development of new drugs has been directed towards the synthesis of hybrid molecules, designed by the combination of different pharmacophores 15 . Inspired by the biological activity of the dihydropyrimidinone 16 and pyridone 17 derivatives, we have synthesized novel poorly‐water soluble azo pyridone dyes based on dihydropyrimidinone core, and their biological properties have been evaluated using in vitro and in silico assays 18 . In particular, their cytotoxic activity has been studied against different cancer cell lines, such as chronic myelogenous leukemia K562, as well as, against human normal lung fibroblasts MRC‐5.…”

“…Additionally, it is important to note that the most stable form of DHPMP is hydrazone form, 18 and it is known that some hydrazones have commercial significance in medicine 23 . Also, the designed DHPMP has consisted of heterocyclic moieties and its degradation has led to the innoxious products 18 …”

Pyridine Scaffolds, Phenols and Derivatives of Azo Moiety: Current Therapeutic Perspectives

“…Azo dyes are one of the most significant classes of chromophores with diverse applications in science and industry, with simplistic synthesis approach can yield a broad spectrum derivatives. Specifically, the synthesis of heterocyclic azo dyes has gained particular attention from the several decades as they exhibit antifungal, anti-convulsant, anti-inflammatory, anti-tubercular, DNA binding and analgesic properties [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ].…”