An efficient and eco-friendly green methodology is developed for the synthesis of series of a-aminophosphonate derivatives from diverse aldehydes, anilines and triethyl phosphite by using environmentally benign and cost-effective Eggshells as solid heterogeneous base catalyst. The reaction is conducted by the stepwise one pot condensation through Kabachnick-Fields addition reaction in ethanol at room temperature during 25-30 min. High yield, short reaction time, solvent-free condition, waste to wealth, and optimization with the design of experiment are the major advantages of this method. In addition, this study examines the influence of different solvents, temperature and the amount of catalyst on the yield of the reaction. A single crystal of (2S)diethyl (phenyl) ((4-fluorophenyl)-aminophosphonate (3g) has been obtained after recrystallization from ethanol/dichloromethane (9/1) and selected for X-ray diffraction study. Compound 3g crystallizes in the monoclinic space group P2 1 /c. The structure of the obtained compounds was confirmed by 1 H, 13 C, and 31 P NMR spectroscopy, IR spectroscopy, as well as elemental analysis.
In this work, a new heterogeneous catalyst based on 1,2,3‐triazole complex of copper supported on core–shell Fe3O4@SiO2 nanoparticles was designed and characterized by using several methods such as infrared spectroscopy (FTIR), X‐ray diffraction (XRD), thermogravimetry analysis (TGA), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and energy‐dispersive X‐ray spectroscopy (EDX). The magnetic nanocatalyst was successfully employed for the synthesis of different functionalized 3,4‐dihydropyrimidin‐2(1H)‐ones/thiones by a one‐pot multicomponent condensation reaction under solvent‐free conditions. Among the advantages of the developed catalytic protocol are the high yields, short reaction times, ecofriendly, easy workup and purification conditions.
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