Novel ATPase activity of the polyprotein intermediate, Viral Protein genome-linked-Nuclear Inclusion-a protease, of Pepper vein banding potyvirus

Mathur, Chhavi; Savithri, H.S.

doi:10.1016/j.bbrc.2012.09.020

Cited by 12 publications

(14 citation statements)

References 36 publications

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“…The slow release of VPg from the NIa fusion, consisting of the Nterminal VPg domain and the C-terminal NIa-Pro protease domain, is required for the infectivity of the Tobacco etch virus (TEV; genus Potyvirus) (Schaad et al, 1996). Furthermore, the interaction of the VPg domain with the NIa-Pro domain increases the protease turnover in Pepper vein banding virus (PVBV; genus Potyvirus) (Mathur et al, 2012). The VPg-mediated structural and functional modulation of NIa-Pro may, therefore, regulate viral proteolytic activity at particular stages of the virus life cycle.…”

Section: Regulation Of Potyviral Protein Amounts and Functionsmentioning

confidence: 99%

Molecular and cellular mechanisms underlying potyvirus infection

Ivanov

Eskelin

Lõhmus

et al. 2014

Journal of General Virology

129

109

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Potyviruses represent one of the most economically important and widely distributed groups of plant viruses. Despite considerable progress towards understanding the cellular and molecular basis of their pathogenicity, many questions remain about the mechanisms by which potyviruses suppress host defences and create an optimal intracellular environment for viral translation, replication, assembly and spread. The review focuses on the multifunctional roles of potyviral proteins and their interplay with various host factors in different compartments of the infected cell. We place special emphasis on the recently discovered and currently putative mechanisms by which potyviruses subvert the normal functions of different cellular organelles in order to establish an efficient and productive infection.

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Section: Regulation Of Potyviral Protein Amounts and Functionsmentioning

confidence: 99%

Molecular and cellular mechanisms underlying potyvirus infection

Ivanov

Eskelin

Lõhmus

et al. 2014

Journal of General Virology

129

109

View full text Add to dashboard Cite

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“…Competition in binding the initiation factor eIF4E or degradation of plant mRNAs by VPg ribonuclease activity may interfere with and hinder the host proteosynthesis (Grzela et al, 2006;Cotton et al, 2006). ATPase activity of the VpG has been recently demonstrated and presented in connection with its potential functions, particularly with cell-to-cell or long distance movement of potyviruses (Mathur and Savithri, 2012).…”

Section: Expression Strategy and Non-structural Proteinsmentioning

confidence: 99%

Unfolding the secrets of plum pox virus: from epidemiology to genomics

Šubr¹,

Glasa²

2013

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Summary. -Over an approximately 80-year period since the description of the Sharka disease, the plum pox virus (PPV) has been thoroughly studied on various levels of the infection cycle. World-wide distribution of the virus, severity of the disease for the fruit industry with a potential to be further increased and discovery/ emergence of new strains make PPV the most epidemiologically important viral pathogen of stone fruit trees. The history of PPV research reflects the development of analytical methods applicable in plant virology. In particular the establishment of molecular biology with reverse genetics and improvement of DNA sequencing technology have further contributed to the increase in knowledge on PPV variability, evolution, replication and interaction with host plants. This review gives a comprehensive summary of PPV data accumulated progressively, from the biological characterization of the disease to recent attempts aimed at using the PPV-based vectors for expression of exogenous proteins in plants.

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“…It has been demonstrated that the interaction of Sesbania mosaic virus (SeMV) protease with VPg in cis-(Protease-VPg) leads to the activation of the protease (Satheshkumar et al, 2005). Similarly VPg covalently linked to the N-terminus of pepper vein banding virus (PVBV) protease NIaPro (VPg-NIaPro) results in the enhancement of activity (Mathur & Savithri, 2012). In both these cases, the interaction of the disordered VPg domain alters the structure and function of the interacting proteases.…”

Section: Viral Proteasesmentioning

confidence: 99%

Viruses and viral proteins

Verdaguer

Ferrero

Murthy

2014

Int Union Crystallogr J

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For more than 30 years X-ray crystallography has been by far the most powerful approach for determining the structures of viruses and viral proteins at atomic resolution. The information provided by these structures, which covers many important aspects of the viral life cycle such as cell-receptor recognition, viral entry, nucleic acid transfer and genome replication, has extensively enriched our vision of the virus world. Many of the structures available correspond to potential targets for antiviral drugs against important human pathogens. This article provides an overview of the current knowledge of different structural aspects of the above-mentioned processes.

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Novel ATPase activity of the polyprotein intermediate, Viral Protein genome-linked-Nuclear Inclusion-a protease, of Pepper vein banding potyvirus

Cited by 12 publications

References 36 publications

Molecular and cellular mechanisms underlying potyvirus infection

Molecular and cellular mechanisms underlying potyvirus infection

Unfolding the secrets of plum pox virus: from epidemiology to genomics

Viruses and viral proteins

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