Molecular and cellular mechanisms underlying potyvirus infection

Ivanov, Konstantin I.; Eskelin, Katri; Lõhmus, Andres; Mäkinen, Kristiina

doi:10.1099/vir.0.064220-0

Cited by 129 publications

(131 citation statements)

References 168 publications

(251 reference statements)

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“…One of them is the small nuclear inclusion protein, NIa. Despite of its involvement in viral replication on the surface of the cytoplasmic membranes, this protein accumulates predominantly in the nucleus of infected cells (Ivanov et al, 2014). The elicitor of Ry-mediated resistance is presumably NIa, a proteinase, which interact directly or indirectly with the Ry protein and initiate a primary response leading to ER by preventing virus accumulation at an early stage of infection.…”

Section: Genes Associated With Er Type Resistancementioning

confidence: 99%

“…These experiments showed that the potyvirus-induced changes are not as pronounced at the proteome level as they are at the transcriptome level. It was concluded that the potyvirus infection induces selective changes in the host gene expression rather than a complete shut-off of protein synthesis (Ivanov et al, 2014).…”

Section: Effects Of Viruses On Potato Gene Expressionmentioning

confidence: 99%

“…The virions are 680-900 nm in length and 11-15 nm in width. An important property of potyviruses is that 10 out of 11 proteins that they encode are derived from a single polyprotein precursor, while the 11 th , P3N-PIPO, results from a separate translation event (Ivanov et al, 2014). The 10 functional proteins are cleaved by the action of three virally coded proteases, namely Hc-Pro, P1 and NIb (Kerlan, 2006).…”

Section: Genome Organization Of Pvy and Pvxmentioning

confidence: 99%

“…Successful infection of host plants by viruses requires cell-to-cell movement through plasmodesmata (Carrington et al, 1996). In the cell-to-cell movement four viral proteins, the CI, VPg, CP and P3N-PIPO, are thought to be involved (Ivanov et al, 2014).…”

Section: Genome Organization Of Pvy and Pvxmentioning

confidence: 99%

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Review Article: Molecular Mechanisms of Resistance to Potato virus X and Y in Potato

Kopp¹,

Kondrák²,

Bánfalvi³

2015

Acta Phytopathologica et Entomologica Hungarica

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The most important viral pathogens of the cultivated potato are Potato virus X (PVX) and Potato virus Y (PVY), which can reduce potato production up to 80%. Thus resistance breeding is one of the major goals of plant breeders. Wild potato species are good sources of resistance (R) genes. The resistant plants respond to viral infection with hypersensitive reaction (HR) or extreme resistance (ER). HR is accompanied by programmed cell death, while ER localizes the virus at the primary infection site and limits virus replication without visible symptoms. While HR is generally strain-specific, ER can act against a broad spectrum of viral pathogens. This review aims to describe the molecular mechanisms of resistance against PVX and PVY in potato.

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Section: Genes Associated With Er Type Resistancementioning

confidence: 99%

Section: Effects Of Viruses On Potato Gene Expressionmentioning

confidence: 99%

Section: Genome Organization Of Pvy and Pvxmentioning

confidence: 99%

Section: Genome Organization Of Pvy and Pvxmentioning

confidence: 99%

See 2 more Smart Citations

Review Article: Molecular Mechanisms of Resistance to Potato virus X and Y in Potato

Kopp¹,

Kondrák²,

Bánfalvi³

2015

Acta Phytopathologica et Entomologica Hungarica

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“…Potyvirus genome consists of a ssRNA+ of approximately 10,000 nucleotides (nt) encapsidated in long and flexuous virions Ivanov et al, 2014) (Figure 3A). The genome is covalently linked in its 5' end to the viral protein genome-linked (VPg) and in its 3' end is polyadenilated.…”

Section: A Potyvirus-based Expression Vector For Metabolic Engineeringmentioning

confidence: 99%

Metabolic engineering of plants using a disarmed potyvirus vector

Majer¹

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Potyviridae

Vallí

Garcı́a

López‐Moya

2015

Encyclopedia of Life Sciences

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The Potyviridae family comprises several genera of plant‐infecting single‐stranded positive‐sense RNA viruses, with flexible and filamentous virion particles. Currently, eight genera are recognised within the family, including the large genus Potyvirus with near 150 aphid‐transmitted viruses. The rest of genera, Brambyvirus , Bymovirus , Ipomovirus , Macluravirus , Poacevirus , Rymovirus and Tritimovirus , are differentiated by their genome composition and structure (two RNA molecules for bymoviruses, one for the rest of genera), by the vector organisms responsible of their dissemination and by genome sequence similarity. Globally very important as pathogens, they also have drawn the attention of the research community for years to study aspects such as taxonomy, evolution, virion structure, functional characterisation of viral proteins, diagnosis, control, interaction with hosts and vectors and even biotechnological applications. Recent advances concerning viruses within the family are being presented. Key Concepts Members of the family Potyviridae are positive‐strand RNA viruses infecting plants, with genomes directly translated in large polyproteins that are proteolytically processed by virus‐encoded proteinases. The family Potyviridae is the largest group of RNA plant viruses. It consists of eight genera, seven of them including viruses with monopartite genomes and a genus that includes viruses with bipartite genomes. Virus particles of members of the family Potyviridae are flexuous rods formed by multiple subunits of a single capsid protein. The replication of viruses of the family Potyviridae takes place in virus‐induced membranous structures. Membrane vesicles induced by viral proteins, likely including replication complexes, move cell‐to‐cell during infection. Viruses of the family Potyviridae may cause a large range of macroscopic symptoms, which in many cases result in serious diseases of crops with high socio‐economical relevance. A very distinctive microscopic feature of Potyviridae infections is the accumulation of pinwheel‐shaped cylindrical inclusions. Members of the family Potyviridae usually can be transmitted by mechanical means; however, in nature, these viruses are vector‐transmitted by specific types of arthropods or plasmodiophorids, depending on the genera. Some viruses in the family Potyviridae have restricted host ranges. However, many other members of the family are able to infect numerous plant species, and alternative hosts can greatly affect the incidence and epidemiology of these viruses. The large number of viruses in the family illustrates their evolutive success with different driving forces operating during speciation, including host adaptation and recombination events when more than one virus infect the same host plant. Both engineered vectors based on members of the family Potyviridae and genetic elements derived from them have been exploited as tools of biotechnological utility. From both economic and scientific standpoints, the family Potyviridae can be considered in any top list, as evidenced by the fast‐growing numbers of hits in general or scientific literature Internet search engines.

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Molecular and cellular mechanisms underlying potyvirus infection

Cited by 129 publications

References 168 publications

Review Article: Molecular Mechanisms of Resistance to Potato virus X and Y in Potato

Review Article: Molecular Mechanisms of Resistance to Potato virus X and Y in Potato

Metabolic engineering of plants using a disarmed potyvirus vector

Potyviridae

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