Novel anionic fluorine-containing amphiphilic self-assembly polymer micelles for potential application in protein drug carrier

Amphiphilic Fluorine-Containing Block Copolymers as Carriers for Hydrophobic PtTFPP for Dissolved Oxygen Sensing, Cell Respiration Monitoring and In Vivo Hypoxia Imaging with High Quantum Efficiency and Long Lifetime

“…Therefore, the lifetime in the range of 70–76 µs reported here is among the longest ones in the known literature, showing the advantage of the use of fluorine-containing multi-arm block copolymers. On the other hand, previously we reported that PtTFPP in micelles could achieve high quantum efficiency of 20–23%, however through FRET enhancement [ 27 , 30 ].…”

“…On the other hand, fluorine is super hydrophobic. It has been reported that micelles formed from fluorine-containing amphiphilic polymers exhibited high stability and nontoxicity which can be used as protein drug carriers [ 30 ]. Based on the former research on perfluorocarbon oxyglobin, fluorine has greater capacity to dissolve, carry and permeate oxygen [ 31 ].…”

Shape Memory Actuation of Janus Nanoparticles with Amphipathic Cross-Linked Network

“…SU-PCL is an amphipathic copolymer with good biocompatibility that has great potential in drug delivery. 38 The amphipathic multiarm SU-PCL was synthesized using the protection/deprotection technique for sucrose via trimethylsilyl groups and ring-opening polymerization (ROP) of ε-caprolactone according to the following steps in Figure 1. Compared to previously used polysaccharose, sucrose was first used as the initiator of a PCL ring-open polymerization to obtain an amphipathic copolymer.…”

“…A well-defined network with biodegradable sucrose-poly­(ε-caprolactone) (SU-PCL) copolymer was used to prepare the initial spherical hydrophilic nanoparticles. SU-PCL is an amphipathic copolymer with good biocompatibility that has great potential in drug delivery . The amphipathic multiarm SU-PCL was synthesized using the protection/deprotection technique for sucrose via trimethylsilyl groups and ring-opening polymerization (ROP) of ε-caprolactone according to the following steps in Figure .…”

[(F6acac)Pd(μ-HNC6F5)]2, a Large Family of Polymorphs and Solvates with Short F···F Contacts

“…Among the weak intermolecular interactions, fluorine–fluorine interactions for a long time have been expected to provide only a small stabilization contribution to the crystal packing, if any at all. , F···F short contacts, with F···F distance shorter than the sum of the VDW radii (2.94 Å), have often been considered a consequence of tight crystal packing − where fluorine atoms approach each other’s neutral region of electrostatic potential surface to minimize repulsion, according to Type I halogen bonding classification. , For this reason, their role in influencing a compound’s solid state properties is still questioned and investigated . In recent years, there has been an increasing number of reports that highlight how F···F interactions can be a driving force for the crystal packing, or provide stabilization that contributes to the formation of structural patterns, motifs, and polymorphs, and that affects the physical properties of compounds. − It has been shown that fluorine can drive the self-assembly of copolymers, nanoparticles, and organic and organometallic compounds. − For this reason, there is increasing effort in life sciences and material sciences to investigate the nature and energetics of F···F interactions, by computational − and structural − studies. Historically, weak (vide infra), F···F interactions were noted in 1954 in connection with an anomalous reversible first-order transition in poly­(tetrafluoroethylene) and later recognized as important in another fluorinated polymer, poly­(vinylidene difluoride) .…”