Novel and simple approach using synthesized nickel nanoparticles to control blood-sucking parasites

Rajakumar, Govindasamy; Rahuman, Abdul Abdul; Velayutham, Kanayairam; Ramyadevi, Jeyaraman; Jeyasubramanian, K.; Marikani, A.; Elango, Gandhi; Kamaraj, Chinnaperumal; Santhoshkumar, Thirunavukkarasu; Marimuthu, Sampath; Zahir, Abdul Abduz; Bagavan, Asokan; Jayaseelan, Chidambaram; Kirthi, Arivarasan Vishnu; Iyappan, Moorthy; Chidambaram, Siva

doi:10.1016/j.vetpar.2012.08.028

Cited by 31 publications

(7 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ni NPs synthesized by chemical route showed antiparasitic activity against H. anatolicum and R. ( B .) microplus larvae with 100% mortality at 25 mg/l [ 44 ]. For unfed adults, ZnO NPs did not record mortality even at the highest concentration of 32 mg/ml; this may return to the highly chitinized cuticles of the unfed adults while Butox®5.0 recorded 100% mortality for unfed adults.…”

Section: Discussionmentioning

confidence: 99%

Acaricidal Efficacy of Biosynthesized Zinc Oxide Nanoparticles Against Hyalomma dromedarii (Acari: Ixodidae) and Their Toxic Effects on Swiss Albino Mice

et al. 2022

View full text Add to dashboard Cite

Purpose The current study aimed to investigate the efficacy of zinc oxide nanoparticles (ZnO NPs) synthesized by Melia azedarach aqueous extract to control Hyalomma dromedarii tick, and to evaluate their toxic effects on Swiss albino mice. Methods ZnO NPs were synthesized using M. azedarach aqueous extract. UV–visible spectroscopy, Fourier transform infrared spectroscopy, scanning electron microscopy, and energy-dispersive spectroscopy were used to characterize the synthesized NPs. Egg, nymph, larva, and adult immersion tests were used for bioassay of tick stages with the synthesized ZnO NP. A toxicity study was performed on Swiss albino mice after treatment with 1/10 of the oral LD50 of ZnO NPs (8437 mg/kg) for 5 successive days by oral gavage. Results The LC50 of ZnO NPs on the eggs, larvae, and nymphs was 11.6, 8.03, and 3.9 mg/ml, respectively. The reproductive performance of females treated with ZnO NPs was lower than that of untreated females. The hematological results showed an insignificant increase in the level of white blood cells with normal red blood cells, hemoglobin, in addition to normal platelet count. The biochemical analysis showed an insignificant increased level (P > 0.05) of alkaline phosphatase and alanine aminotransferase. The liver and kidney suffered few histopathological changes after oral administration of ZnO NPs. Conclusion These results suggest that ZnO NPs have good acaricidal activity against eggs, larvae, and engorged nymphs of H. dromedarii. ZnO NPs minimized the number of eggs laid by engorged females and the hatchability of their eggs. ZnO NPs did not affect unfed adults. The toxicity results of the mice revealed insignificant changes in the hemogram, biochemistry, with liver and kidney suffering few histopathological changes. Future studies are needed to assess application routes (topical vs oral). Based on these findings, ZnO NPs may be incorporated in the control of camel tick H. dromedarii.

show abstract

Section: Discussionmentioning

confidence: 99%

Acaricidal Efficacy of Biosynthesized Zinc Oxide Nanoparticles Against Hyalomma dromedarii (Acari: Ixodidae) and Their Toxic Effects on Swiss Albino Mice

et al. 2022

View full text Add to dashboard Cite

show abstract

“…On the other hand, the indiscriminate overuse of synthetic acaricides has led to concerns related to environmental pollution, non-target toxicity, and development of resistance in targeted tick populations (Naqqash et al, 2016). Therefore, environmentally friendly and cost-effective methods to protect humans and domestic animals from ticks would be welcome and attractive to global market of acaricides (Marimuthu et al, 2011(Marimuthu et al, , 2013Velayutham et al, 2012;Lupi et al, 2013;Rajakumar et al, 2013;Khater et al, 2016;Banumathi et al 2017).…”

Section: Introductionmentioning

confidence: 99%

Toxic and repellent activity of selected monoterpenoids (thymol, carvacrol and linalool) against the castor bean tick, Ixodes ricinus (Acari: Ixodidae)

Tabari

Youssefi

Maggi

et al. 2017

Veterinary Parasitology

121

View full text Add to dashboard Cite

The castor bean tick, Ixodes ricinus, is a species of medical and veterinary importance. The use of synthetic acaricides for tick control has led to development of resistance, residues in the environment and animal products, and public health concerns. In this regard, plant essential oils and their main constituents represent an appealing alternative strategy to combat ticks. The phenols thymol and carvacrol and the alcohol linalool are monoterpenoids occurring in essential oils of several aromatic and medicinal plants, such as thyme, oregano, savory, lavender and coriander. Recent studies have shown toxicity of these monoterpenoids against selected mosquito vectors and other arthropod pests. However, information on their bioactivity on I. ricinus is not available. On this basis, here we evaluated the ovicidal, larvicidal and repellency effects of these compounds against I. ricinus. Concentrations of 0.25, 0.5, 1, 2 and 5% were sprayed on the egg masses, then hatching rates were noted. Larvicidal assays were conducted on unengorged larvae, following the larval packet technique. The repellency was determined by measuring the vertical migration behavior of ticks in laboratory conditions. Carvacrol and thymol at all concentrations tested led to a significant hatching decrease, showing an efficacy higher than permethrin, whereas linalool did not cause any significant effect. In the larvae treated with carvacrol and thymol (1, 2 and 5%), mortality rates reached 100% after 24h, showing a larvicidal efficacy higher than permethrin, whereas no effect was seen in the larval groups treated with linalool. Carvacrol and thymol at all concentrations tested showed >90% repellency on I. ricinus. Linalool was scarcely effective (50.24% repellency) only at the concentration of 5%. Overall, based on these results, the phenols carvacrol and thymol can be considered as candidate ingredients for the development of novel acaricidal formulations to control the populations of I. ricinus and the spread of related tick-borne diseases.

show abstract

“…Studies have reported the promising results of titanium dioxide nanoparticles (having LC 50 = 5.43 mg/L), Eucalyptus-globulus -loaded nano-emulsions (controlling female reproduction up to 97.8%), and copper nanoparticles (having LC 50 = 14.14 mg/L) against the adult stages of R. microplus, respectively [ 35 , 36 , 37 ]. Similarly, nickel nanoparticles (having LC 50 = 10.17 mg/L), plant-based silver nanoparticles showing LC 50 = 7.61 mg/L, and nanoparticles synthesized from cinnamon oil showing a maximum inhibition at 5% have been reported against the larval stages of Rhipicephalus ticks [ 38 , 39 , 40 ]. Owing to the fine particle size capable of both the up- and down-regulation of oxidative and cell injury pathways in ticks [ 27 ], the nanomaterials have shown enhanced acaricidal potential when compared to the herbal/chemical constituents alone.…”

Section: Discussionmentioning

confidence: 99%

Application of Cypermethrin-Coated ZnS and ZnO Nanoparticles against Rhipicephalus Ticks

et al. 2023

View full text Add to dashboard Cite

Rhipicephalus ticks are described as important ticks impacting the costs of livestock rearing and by-products sale. The prevalence and response of ticks towards cypermethrin sprays indicate the need to implement the rational use of acaricides. In our previous studies, ZnO nanoparticles were shown to inhibit the major life-cycle stages of Hyalomma ticks, indicative of promising application of nanomaterials against the hard ticks. The current study was designed to probe into one of alternative options to curtail Rhipicephalus ticks by employing cypermethrin-coated nanoparticles of ZnO (C-ZnO NPs) and ZnS (C-ZnS NPs). The nanocomposites showed a roughly spherical type of morphology and various size dimensions upon characterization using SEM and EDX. Female ovipositioning was declined up to only 48% in ZnS and up to 32% in ZnO NPs even after 28 days in vitro. Similarly, the larval hatching was also impacted, leading to a hatching percentage of 21% and 15% by application of C-ZnS NPs and C-ZnO NPs, respectively. The LC90 in female adult groups were 3.94 mg/L and 4.27 mg/L for the C-ZnO NPs and C-ZnS NPs groups, respectively. Similarly, the larval groups had LC90 of 8.63 and 8.95 mg/L for the C-ZnO NPs and C-ZnS NPs groups. The study is a proof of the concept for incorporating effective and safe nanocomposites as acaricides. The studies on the efficacy and spectrum of non-target effects of nanomaterial-based acaricides can further refine the research on finding novel alternatives for tick control.

show abstract

Novel and simple approach using synthesized nickel nanoparticles to control blood-sucking parasites

Cited by 31 publications

References 32 publications

Acaricidal Efficacy of Biosynthesized Zinc Oxide Nanoparticles Against Hyalomma dromedarii (Acari: Ixodidae) and Their Toxic Effects on Swiss Albino Mice

Acaricidal Efficacy of Biosynthesized Zinc Oxide Nanoparticles Against Hyalomma dromedarii (Acari: Ixodidae) and Their Toxic Effects on Swiss Albino Mice

Toxic and repellent activity of selected monoterpenoids (thymol, carvacrol and linalool) against the castor bean tick, Ixodes ricinus (Acari: Ixodidae)

Application of Cypermethrin-Coated ZnS and ZnO Nanoparticles against Rhipicephalus Ticks

Contact Info

Product

Resources

About