Novel and selective potentiometric sensors for Cinchocaine HCl determination in its pure and Co-formulated dosage form: A comparative study of in situ carbon sensors based on different ion pairing agents

Elashery, Sally E.A.; Frag, Eman Yossri; Sleim, Ashraf A.E.

doi:10.1016/j.measurement.2020.108549

Cited by 20 publications

(14 citation statements)

References 68 publications

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“…The metal wire is used as a substrate which is coated with a polymeric cocktail containing the active sites of the selective membrane [42]. Sodium tetraphenylborate (Na-TPB) is a white powder that has the ability to catalyze the ion-exchange process via the interfaces of hydrophobic membrane when used with a suitable ion-pair complex [43].…”

Section: Introductionmentioning

confidence: 99%

New Construction of Functionalized CuO/Al2O3 Nanocomposite-Based Polymeric Sensor for Potentiometric Estimation of Naltrexone Hydrochloride in Commercial Formulations

2021

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Electrically conductive polymeric nanocomposites with nanoparticles are adaptable types of nanomaterials that are prospective for various applications. The extraordinary features of copper oxide (CuO) and aluminium oxide (Al2O3) nanostructures, encourages extensive studies to prospect these metal oxide nanocomposites as potential electroactive materials in sensing and biosensing applications. This study suggested a new CuO/Al2O3 nanocomposite-based polymeric coated wire membrane sensor for estimating naltrexone hydrochloride (NTX) in commercial formulations. Naltrexone hydrochloride and sodium tetraphenylborate (Na-TPB) were incorporated in the presence of polymeric polyvinyl chloride (PVC) and solvent mediator o-nitrophenyloctyl ether (o-NPOE) to form naltrexone tetraphenylborate (NTX-TPB) as an electroactive material. The modified sensor using NTX-TPB-CuO/Al2O3 nanocomposite displayed high selectivity and sensitivity for the discrimination and quantification of NTX with a linearity range 1.0 × 10−9–1.0 × 10−2 mol L−1 and a regression equation EmV = (58.25 ± 0.3) log [NTX] + 754.25. Contrarily, the unmodified coated wire sensor of NTX-TPB exhibited a Nernstian response at 1.0 × 10−5–1.0 × 10−2 mol L−1 and a regression equation EmV = (52.1 ± 0.2) log [NTX] + 406.6. The suggested modified potentiometric system was validated with respect to various criteria using the methodology recommended guidelines.

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Section: Introductionmentioning

confidence: 99%

New Construction of Functionalized CuO/Al2O3 Nanocomposite-Based Polymeric Sensor for Potentiometric Estimation of Naltrexone Hydrochloride in Commercial Formulations

2021

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“…The electrodes were investigated by varying the ratios ( w / w ) of graphite, IAC, rGO, solvent mediator, and anionic additive, until the optimum composition that exhibits the best response characteristics was achieved. According to the literature, all the components were made homogenous in an agate mortar [ 36 , 45 ]. The obtained smooth paste was carefully packed into a laboratory made polytetrafluoroethylene electrode body (Teflon holder) ( Figure S1, Supplementary Materials ).…”

Section: Methodsmentioning

confidence: 99%

“…However, PVC based membranes exhibit several disadvantages, such as leaching of plasticizers and membrane ionophores, limited adhesion of supporting materials in addition to high water uptake [ 45 , 46 ]. On the other hand, CPE are easier to fabricate.…”

Section: Introductionmentioning

confidence: 99%

A Novel Reduced Graphene Oxide Modified Carbon Paste Electrode for Potentiometric Determination of Trihexyphenidyl Hydrochloride in Pharmaceutical and Biological Matrices

Radić

Buljac

Genorio

et al. 2021

Sensors

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A novel promising carbon paste electrode with excellent potentiometric properties was prepared for the analysis of trihexyphenidyl hydrochloride (THP), the acetylcholine receptor and an anticholinergic drug in real samples. It contains 10.2% trihexyphenidy-tetraphenylborate ionic pair as the electroactive material, with the addition of 3.9% reduced graphene oxide and 0.3% of anionic additive into the paste, which consists of 45.0% dibutylphthalate as the solvent mediator and 40.6% graphite. Under the optimized experimental conditions, the electrode showed a Nernstian slope of 58.9 ± 0.2 mV/decade with a regression coefficient of 0.9992. It exhibited high selectivity and reproducibility as well as a fast and linear dynamic response range from 4.0 × 10−7 to 1.0 × 10−2 M. The electrode remained usable for up to 19 days. Analytical applications showed excellent recoveries ranging from 96.8 to 101.7%, LOD was 2.5 × 10−7 M. The electrode was successfully used for THP analysis of pharmaceutical and biological samples.

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“…A graphite pencil|Britton-Robinson buffer DPV SWV 1.5-18 1-11 0.7 ± 0.05 0.5 ± 0.06 [21] An activated glassy carbon|Britton-Robinson buffer DPV SWV 1.3-14 2-28 0.4 ± 0.002 0.9 ± 0.003 [21] Silver nanoparticle on glassy carbon electrode DPV 18.5-72.2 0.002 [22] An ion-selective electrode Potentiometric 1-10 0.7 [54] In situ carbon paste electrodes Potentiometric 10-10,000 10 ± 0.14 [55] Water|1,6-DCH DPV 4-24 0.9 ± 0.06 This work…”

Section: Interface Detection Methods Linear Range (µM) Lod (µM) ± Sd Rmentioning

confidence: 99%

Electrochemical Detection of a Local Anesthetic Dibucaine at Arrays of Liquid|Liquid MicroInterfaces

et al. 2021

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Electrochemical characterization and detection of protonated dibucaine (DIC+) at microinterface array across water|1,6-dichlorohexane were performed using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Some thermodynamic parameters of dibucaine, such as the standard transfer potential, the Gibbs energy of transfer and the partition coefficient, were estimated by CV. In addition to the analytical parameters, the impact of bovine serum albumin (BSA) on dibucaine detection (in artificial serum matrices) was also investigated. DPV was applied to detect a lower concentration of DIC+, resulting in a detection limit of 0.9 ± 0.06 µM. While the presence of BSA affected CV, demonstrated as reduced current responses, DPV was confirmed to be an efficient method for lowering concentrations of the dibucaine detection in the artificial serum matrix in the presence of BSA, with a limit of detection (LOD) of 1.9 ± 0.12 µM.

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Novel and selective potentiometric sensors for Cinchocaine HCl determination in its pure and Co-formulated dosage form: A comparative study of in situ carbon sensors based on different ion pairing agents

Cited by 20 publications

References 68 publications

New Construction of Functionalized CuO/Al2O3 Nanocomposite-Based Polymeric Sensor for Potentiometric Estimation of Naltrexone Hydrochloride in Commercial Formulations

New Construction of Functionalized CuO/Al2O3 Nanocomposite-Based Polymeric Sensor for Potentiometric Estimation of Naltrexone Hydrochloride in Commercial Formulations

A Novel Reduced Graphene Oxide Modified Carbon Paste Electrode for Potentiometric Determination of Trihexyphenidyl Hydrochloride in Pharmaceutical and Biological Matrices

Electrochemical Detection of a Local Anesthetic Dibucaine at Arrays of Liquid|Liquid MicroInterfaces

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