Electrochemical Detection of a Local Anesthetic Dibucaine at Arrays of Liquid|Liquid MicroInterfaces

Abstract

Electrochemical characterization and detection of protonated dibucaine (DIC+) at microinterface array across water|1,6-dichlorohexane were performed using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Some thermodynamic parameters of dibucaine, such as the standard transfer potential, the Gibbs energy of transfer and the partition coefficient, were estimated by CV. In addition to the analytical parameters, the impact of bovine serum albumin (BSA) on dibucaine detection (in artificial serum matrices) was also investigated. DPV was applied to detect a lower concentration of DIC+, resulting in a detection limit of 0.9 ± 0.06 µM. While the presence of BSA affected CV, demonstrated as reduced current responses, DPV was confirmed to be an efficient method for lowering concentrations of the dibucaine detection in the artificial serum matrix in the presence of BSA, with a limit of detection (LOD) of 1.9 ± 0.12 µM.

Review—Novel Trends in the Determination of Pharmaceutical Compounds Commonly Found in Topical Treatments using Electrochemical Sensing Approaches

“…Moreover, the influence of bovine serum albumin present in artificial serum samples towards the determination of dibucaine was studied with good results. 11 Ghoniem's team developed a functionalized multiwall carbon nanotubes and ionic liquid modified carbon paste electrode (CPE/IL-f.CNT). The functionalization involved the oxidation of carbon nanotubes in the presence of sulfuric acid.…”

Advances in Wearable Chemosensors

“…Recently, microfluidics technology has gained attention because of the reduction in samples and solvent quantities required, resulting in lesser amounts of residue. This technology seems to have great prominence in wearable chemosensor platforms since it can be applied in portable sensor devices of various configurations and composition of the detector [33][34][35], whilst a local anesthetic (dibucaine) was detected with success at arrays of liquid/liquid micro interfaces [36]. Additionally, 2D and 3D printing technologies are used to develop new systems or upgrade existing ones, such as inkjet printing of wireless chemosensors [37].…”