2020
DOI: 10.4251/wjgo.v12.i9.957
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Abstract: Cholangiocarcinoma (CCA) comprises of extra-hepatic cholangiocarcinoma and intrahepatic cholangiocarcinoma cancers as a result of inflammation of epithelium cell lining of the bile duct. The incidence rate is increasing dramatically worldwide with highest rates in Eastern and South Asian regions. Major risk factors involve chronic damage and inflammation of bile duct epithelium from primary sclerosing cholangitis, chronic hepatitis virus infection, gallstones and liver fluke infection. Various genetic variants… Show more

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Cited by 13 publications
(14 citation statements)
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References 104 publications
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“…Notch overactivation can result in liver epithelial cell dysplasia and malignant transformation. Indeed, Notch and Hes1 have been implicated in the development of cholangiocarcinoma, and inhibition of the signaling is a potential therapeutic target for the disease 19–21 . This study confirmed that cholangiocarcinoma developing in CD also exhibited nuclear overexpression of Notch1 and Hes1 in the cells.…”
Section: Discussionsupporting
confidence: 75%
“…Notch overactivation can result in liver epithelial cell dysplasia and malignant transformation. Indeed, Notch and Hes1 have been implicated in the development of cholangiocarcinoma, and inhibition of the signaling is a potential therapeutic target for the disease 19–21 . This study confirmed that cholangiocarcinoma developing in CD also exhibited nuclear overexpression of Notch1 and Hes1 in the cells.…”
Section: Discussionsupporting
confidence: 75%
“…In the liver, hepatoblasts are the precursors of hepatocytes and cholangiocytes. Notch signaling can inhibit the differentiation of hepatoblasts into hepatocytes, allowing cholangiocyte formation [ 22 , 23 ]. Both the loss and gain of Notch functions may contribute to liver cancer development including both cholangiocarcinoma (CC) and HCC and different Notch receptors have different functions during liver cancer development [ 24 ].…”
Section: Notch Genesmentioning
confidence: 99%
“…15,16 The Notch pathway plays a vital role in cholangiocyte differentiation, bile duct development, 17,18 and cholangiocarcinogenesis. 19,20 The overexpression of Notch receptors and ligands, such as Jagged1, has been reported in human iCCA. 19,20 Moreover, using genomic data from a vast iCCA collection, a recent study identified a Notch1 signature in human iCCA, suggesting the use of g-secretase inhibitors to treat this subgroup of patients.…”
mentioning
confidence: 99%
“…19,20 The overexpression of Notch receptors and ligands, such as Jagged1, has been reported in human iCCA. 19,20 Moreover, using genomic data from a vast iCCA collection, a recent study identified a Notch1 signature in human iCCA, suggesting the use of g-secretase inhibitors to treat this subgroup of patients. 21 The oncogenic role of the Notch pathway in iCCA has been investigated and validated in animal models.…”
mentioning
confidence: 99%