Nosocomial outbreaks due to Pseudomonas aeruginosa and Acinetobacter baumannii in a Neonatal Intensive Care Unit (NICU) of the Uberlândia Federal University Hospital

Brito, Denise Von Dolinger de; Oliveira, Elias Jose; Darini, Ana Lúcia da Costa; Abdallah, Vânia O. S.; Gontijo-Filho, Paulo Pinto

doi:10.1590/s1517-83822003000500009

Cited by 5 publications

(5 citation statements)

References 3 publications

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“…According to Ben Jaballah et al 15 , high resistance to third-generation cephalosporin by gram-negative bacilli has increased, including Acinetobacter sp, Enterobacter sp, Serratia marcescens, Klebsiella pneumoniae, and Pseudomonas aeruginosa. This was shown in some of our studies including detection of outbreaks of these pathogens [16][17][18] .…”

Section: Ethical Considerationssupporting

confidence: 62%

Nosocomial infections in a neonatal intensive care unit during 16 years: 1997-2012

Urzedo

Levenhagen

Pedroso

et al. 2014

Rev. Soc. Bras. Med. Trop.

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Introduction: Surveillance of nosocomial infections (NIs) is an essential part of quality patient care; however, there are few reports of National Healthcare Safety Network (NHSN) surveillance in neonatal intensive care units (NICUs) and none in developing countries. The purpose of this study was to report the incidence of NIs, causative organisms, and antimicrobial susceptibility patterns in a large cohort of neonates admitted to the NICU during a 16-year period. Methods: The patients were followed 5 times per week from birth to discharge or death, and epidemiological surveillance was conducted according to the NHSN. Results: From January 1997 to December 2012, 4,615 neonates, representing 62,412 patient-days, were admitted to the NICU. The deviceassociated infection rates were as follows: 17.3 primary bloodstream infections per 1,000 central line-days and 3.2 pneumonia infections per 1,000 ventilator-days. A total of 1,182 microorganisms were isolated from sterile body site cultures in 902 neonates. Coagulase-negative staphylococci (CoNS) (34.3%) and Staphylococcus aureus (15.6%) were the most common etiologic agents isolated from cultures. The incidences of oxacillin-resistant CoNS and Staphylococcus aureus were 86.4% and 28.3%, respectively. Conclusions:The most important NI remains bloodstream infection with staphylococci as the predominant pathogens, observed at much higher rates than those reported in the literature. Multiresistant microorganisms, especially oxacillin-resistant staphylococci and gram-negative bacilli resistant to cephalosporin were frequently found. Furthermore, by promoting strict hygiene measures and meticulous care of the infected infants, the process itself of evaluating the causative organisms was valuable.

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Section: Ethical Considerationssupporting

confidence: 62%

Nosocomial infections in a neonatal intensive care unit during 16 years: 1997-2012

Urzedo

Levenhagen

Pedroso

et al. 2014

Rev. Soc. Bras. Med. Trop.

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“…[ 15 ] Acinetobacter has been implicated in many outbreaks of neonatal sepsis in NICU. [ 7 10 16 ] The isolation rate of Acinetobacter species from blood samples of septicemic neonates in the Indian literature ranges from 8.3% to 15.2%. [ 6 11 17 ] In the present study, Acinetobacter contributed to 10.8% of total septicemia cases.…”

Section: Discussionmentioning

confidence: 99%

Acinetobacter Septicemia in Neonates Admitted to Intensive Care Units

et al. 2009

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Background:Acinetobacter species are gaining importance as potential pathogens in neonatal septicemia because of their frequent isolation and multidrug resistance.Aims and Objectives:The aim of the present study was to evaluate the role of Acinetobacter spp. as important pathogens in neonatal blood stream infection, to identify the associated risk factors, and to evaluate the drug sensitivity pattern.Materials and Methods:Blood samples of infected neonates were studied bacteriologically. Cases of Acinetobacter septicemia were identified. Speciation of Acinetobacter species was done. Various risk factors were identified. The drug-sensitivity test was done.Results:A total of 26 Acinetobacter septicemia cases were identified by blood culture. Acb complex strains predominated. Institutional birth and preterm birth were identified as the most frequent significant risk factors. 11.3% mortality rate was recorded. Acb complex strains exhibited a multi-drug resistant pattern. No carbapenem resistance was observed.Conclusion:Acinetobacter should be added to the list of organisms causing severe nosocomial infection in neonatal intensive care units. Continuous bacteriological surveillance, implementation of infection control policies, careful disinfection of intensive care equipment, and rational antibiotic use are required for control of such infections.

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“…The data were interpreted according to the criteria of the Clinical and Laboratory Standards Institute 2007-2009.…”

Section: Methodsmentioning

confidence: 99%

“…have been the cause of nosocomial outbreaks worldwide (Cortes et al, 2009;Hosoglu et al, 2011), including in Brazil (Brito et al, 2003;Prates et al, 2011), where multidrug resistance is common among these isolates (Rossi, 2011). Carbapenems often represent the only effective treatment.…”

Section: Introductionmentioning

confidence: 99%

High genetic diversity among Pseudomonas aeruginosa and Acinetobacter spp. isolated in a public hospital in Brazil

Siqueira

Cardoso²,

Pádua³

et al. 2013

Braz. J. Pharm. Sci.

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In Brazil and other regions of the world, Pseudomonas aeruginosa and Acinetobacter spp. have emerged as important agents of nosocomial infection and are commonly involved in outbreaks. The main objective of the present study was to evaluate the genetic relationship among P. aeruginosa and Acinetobacter spp. isolated from patients in a public university hospital in northwestern Paraná, Brazil, and report their antimicrobial resistance profile. A total of 75 P. aeruginosa and 94 Acinetobacter spp. isolates were phenotypically identified and tested for antibiotic susceptibility using automated methodology. Polymyxin B was tested by disk diffusion for P. aeruginosa. Metallo-b-lactamase (MBL) was detected using a disk approximation test. Genotyping was performed using enterobacterial repetitive intergenic consensus polymerase chain reaction (ERIC-PCR). Approximately 55% of the P. aeruginosa isolates and 92% of the Acinetobacter spp. isolates were multiresistant, but none were MBL-producers. ERIC-PCR revealed the presence of small clusters of carbapenem-resistant Acinetobacter spp., most likely OXA-type carbapenemase producers. Furthermore, high genetic diversity in P. aeruginosa and Acinetobacter spp. clinical isolates was observed, suggesting that cross-transmission is not very frequent in the studied hospital. Uniterms:Pseudomonas aeruginosa/antimicrobial resistance profile. Pseudomonas aeruginosa/genetic study. Acinetobacter spp./antimicrobial resistance profile. Acinetobacter spp./genetic study. Antimicrobial resistance. Bacterial typing.No Brasil, bem como em outras regiões do mundo, Pseudomonas aeruginosa e Acinetobacter spp. surgiram como importantes agentes de infecção nosocomial e são comumente envolvidos em surtos. O objetivo principal deste estudo foi descrever a relação genética de P. aeruginosa e Acinetobacter spp. isoladas de pacientes internados em hospital universitário público do noroeste do Paraná -Brasil e reportar o perfil de resistência dessas bactérias. Um total de 75 P. aeruginosa e 94 Acinetobacter spp. isolados foi fenotipicamente identificado e testado para a suscetibilidade aos antibióticos por metodologia automatizada. A polimixina B foi testada por difusão em disco para P. aeruginosa. Metalo-b-lactamase (MBL) foi detectada por disco-aproximação. Análise genotípica foi realizada por enterobacterial repetitive intergenic consensus polymerase chain reaction (ERIC-PCR). Aproximadamente 55% dos isolados de P. aeruginosa e 92% de Acinetobacter spp. isolados foram multirresistentes, mas nenhum foi produtor de MBL. Os resultados de ERIC-PCR revelaram pequenos grupamentos de Acinetobacter spp. resistentes aos carbapenêmicos, provavelmente pela produção de carbapenemases do tipo OXA. Além disso, alta diversidade genética entre os isolados de P. aeruginosa e Acinetobacter spp. foi observada, sugerindo que a transmissão cruzada destas espécies bacterianas não é muito frequente em nosso hospital. Unitermos:Pseudomonas aeruginosa/perfil de resistência. Pseudomonas aeruginosa/estudo genético. Acinetobac...

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Nosocomial outbreaks due to Pseudomonas aeruginosa and Acinetobacter baumannii in a Neonatal Intensive Care Unit (NICU) of the Uberlândia Federal University Hospital

Cited by 5 publications

References 3 publications

Nosocomial infections in a neonatal intensive care unit during 16 years: 1997-2012

Nosocomial infections in a neonatal intensive care unit during 16 years: 1997-2012

Acinetobacter Septicemia in Neonates Admitted to Intensive Care Units

High genetic diversity among Pseudomonas aeruginosa and Acinetobacter spp. isolated in a public hospital in Brazil

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