Acinetobacter Septicemia in Neonates Admitted to Intensive Care Units

Shete, Vishal B; Ghadage, Dnyaneshwari P.; Muley, Vrishali Avinash; Bhore, Arvind V.

doi:10.4103/0974-2727.59704

Cited by 27 publications

(14 citation statements)

References 14 publications

(20 reference statements)

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“…Risk factors for Acinetobacter bloodstream infection include intensive care, mechanical ventilation, prior surgery, prior use of broad-spectrum antibiotics, immunosuppression, trauma, burns, malignancy, central venous catheters and other invasive procedures 4. Risk factors among neonates include low birthweight, total parenteral nutrition and central venous catheters,3 all of which conditions were present in our case and may have led to the development of an infection caused by A. ursingii .…”

Section: Discussionmentioning

confidence: 67%

“…Acinetobacter is a frequent pathogen in healthcare-associated infections, particularly among immunocompromised patients in the intensive care unit 2 3. Although reports from neonatal infections caused by subspecies Acinetobacter ursingii are rare, we report this case to emphasise that it should be kept in mind as an opportunistic micro-organism in neonates admitted to neonatal intensive care units (NICUs) 2 4…”

Section: Introductionmentioning

confidence: 88%

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Late-onset neonatal sepsis:Acinetobacterursingiias an infectious agent

Barros¹,

Garrido²,

Tavares³

et al. 2019

BMJ Case Rep

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The authors report a case of a premature male newborn admitted to the neonatal intensive care unit after an emergent caesarean due to maternal pre-eclampsia and foetal bradycardia at 32 weeks of gestational age and birth weight of 1440 g. There were no infection risk factors reported. On day 3 his clinical condition deteriorated, with tachycardia and subfebrile temperature and C-reactive protein at 1.25 mg/dL. Empirical antibiotics (flucloxacillin and gentamicin) were started, with no clinical improvement and C-reactive protein increasing to a maximum of 19 mg/dL (upper normal level of 1 mg/dL) after 3 days. Blood cultures from the third to the eighth day of life were positive for Acinetobacter ursingii. Targeted therapy was administered for 14 days with clinical and laboratorial improvement and he was discharged on the 28th day of life without any known sequelae. A. ursingii is emerging as an infectious agent of late-onset sepsis in immunosuppressed neonates.

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Section: Discussionmentioning

confidence: 67%

Section: Introductionmentioning

confidence: 88%

Late-onset neonatal sepsis:Acinetobacterursingiias an infectious agent

Barros¹,

Garrido²,

Tavares³

et al. 2019

BMJ Case Rep

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“…and Citrobacter spp. These bacteria are mostly acquired from the hospital environments, health professionals, and medical devices [33,34]. Moreover, as majority of our study participants (84.1%) had early onset neonatal sepsis, the bacterial etiologies identified in our study somehow deviate from expectations [1,3,4].…”

Section: Discussionmentioning

confidence: 68%

Bacterial profile and drug resistance patterns in neonates admitted with sepsis to a tertiary teaching hospital in Ethiopia

Gashaw¹,

Ali²,

Tesfaw³

et al. 2019

Preprint

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Background : Tackling neonatal infections and antibiotic resistance remains a challenge in low-income countries where neonatal mortality is high and antibiotic resistance is growing. The aim of this study was to identify bacterial etiologies and their drug resistance patterns in neonates admitted with diagnosis of sepsis to neonatal intensive care unit at Jimma Medical Center in Ethiopia. Methods : A prospective longitudinal study was conducted from April to October 2018. A total of 313 clinical specimens (211 blood and 102 cerebrospinal fluid) were processed for 238 neonates suspected to have sepsis. Blood culture was done using BD BACTEC FX40 automated system. Bacterial identification and antibiotic susceptibility testing were done according to standard microbiological techniques. Results : Bacterial etiologies were isolated from 62.1% (131/211) and 3.9% (4/102) of blood and cerebrospinal fluid cultures respectively. The predominant bacteria isolated from blood were Coagulase negative Staphylococcus 27.5% (36/131), followed by S. aureus 20.6% (27/131), Klebsiella species 14.5% (19/131), and Acinetobacter species 10.7% (14/131). Nearly 85% of the isolates were multidrug resistant, predominantly observed in Gram-negative bacteria. Among locally available antibiotics, only meropenem for Gram-negatives and vancomycin for Gram-positives were found to be largely effective. Conclusion : Bacterial pathogens identified in the study were highly resistant to available antibiotics. Thus, an effort to reduce neonatal mortality in the setting should focus on improving diagnostics for neonatal infection and containment of antimicrobial resistance.

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“…In all these cases, the A. baumannii infection progressed and caused sepsis. In a study, 4.5% of blood cultures taken from patients hospitalized in all departments were identified as A. baumannii infections [ 15 ]. In neonates, 10.8% of blood isolates were identified as A. baumannii and were implicated with 11.3% mortality rates [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

FatalAcinetobacter baumaniiNecrotizing Fasciitis following Open Reduction Internal Fixation in a Polytrauma Patient

Nehme

Joukhadar

Saidy

et al. 2018

Case Reports in Infectious Diseases

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Necrotizing fasciitis is an uncommon and potentially fatal infection that can affect the epidermis, dermis, and more commonly the subcutaneous, fascia, and muscle layers. NF is usually caused by toxin-producing bacteria with a relatively fast progression associated with severe surrounding tissue destruction. Early diagnosis and management are crucial factors for survival. Broad-spectrum antibiotics along with surgical debridement, sometimes multiple, are needed in order to stop or slow down the progression of NF. Despite optimal care, necrotizing fasciitis remains a highly morbid condition with a high mortality rate. We present a case of a 28-year-old male patient with rapidly developing fatal A. baumannii associated with necrotizing fasciitis, after open reduction and internal fixation (ORIF) of multiple fractures after polytrauma.

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Acinetobacter Septicemia in Neonates Admitted to Intensive Care Units

Cited by 27 publications

References 14 publications

Late-onset neonatal sepsis:Acinetobacterursingiias an infectious agent

Late-onset neonatal sepsis:Acinetobacterursingiias an infectious agent

Bacterial profile and drug resistance patterns in neonates admitted with sepsis to a tertiary teaching hospital in Ethiopia

FatalAcinetobacter baumaniiNecrotizing Fasciitis following Open Reduction Internal Fixation in a Polytrauma Patient

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