2008
DOI: 10.1016/j.neuroimage.2007.12.057
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Normalization in PET group comparison studies—The importance of a valid reference region

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Cited by 86 publications
(86 citation statements)
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“…Although similar to the increases in 18 F-FDG studies, the relative increases in 11 C-raclopride influx observed in PD versus controls and MSA patients, especially in the striatum, do not necessarily represent a surrogate marker of altered neuronal activity and may be influenced by the choice of normalization region, as demonstrated recently by Borghammer et al (25,26).…”
Section: Discussionsupporting
confidence: 68%
“…Although similar to the increases in 18 F-FDG studies, the relative increases in 11 C-raclopride influx observed in PD versus controls and MSA patients, especially in the striatum, do not necessarily represent a surrogate marker of altered neuronal activity and may be influenced by the choice of normalization region, as demonstrated recently by Borghammer et al (25,26).…”
Section: Discussionsupporting
confidence: 68%
“…As detailed previously [9,11], parametric maps of CBF and CMRO 2 were calculated with the single step, two-compartment, three-weighted-integration method of Ohta et al [12,13] which has been successfully used in both normal subjects [11,14,15] and patient studies [16,17], including PD patients [18,19]. The parametric images were smoothed with a Gaussian filter to a final resolution of 14 × 14 × 14 mm 3 .…”
Section: Discussionmentioning
confidence: 99%
“…A previous study found that using a GM/WM CBF ratio allowed subjects with AD to be detected with a greater degree of sensitivity, 19 and the WM has been shown to be a good reference region in older subjects. 20 Full details of the MRI acquisition and processing are found in appendix e-1 on the Neurology ® Web site at www.neurology.org.…”
Section: Neuropsychologic Methodsmentioning
confidence: 99%