Cerebral oxygen metabolism in patients with early Parkinson's disease

Structural and physiological neurovascular changes in idiopathic Parkinson’s disease and its clinical phenotypes

“…For example, decreased mitochondrial electron transport chain activity has been implicated in PD pathogenesis, and there is some evidence to support the occurrence of parallel declines in the rate of cerebral oxygen consumption (CMRO 2 ), glucose utilisation (CMRglc) and CBF in spatially contiguous cortical regions in early PD. 48 There is a need for prodromal studies (for example, in specific individuals with genetic predisposition) and longitudinal studies temporally mapping vascular and neuronal changes.…”

In vivo NMR studies of regional cerebral energetics in MPTP model of Parkinson's disease: recovery of cerebral metabolism with acute levodopa treatment

“…; Borghammer et al . , b). However, the implication of loss of DA neurons in SNc on the regional brain activity, especially cortico‐basal ganglio‐thalamocortical pathway activity at cellular level is poorly understood.…”

Insula Volume and Salience Network Are Associated with Memory Decline in Parkinson Disease: Complementary Analyses of Voxel-Based Morphometry versus Volume of Interest

“…MMSE, representing overall cognitive performance, showed a positive correlation with thickness of the temporal cortices in another study [ 33 ]. In addition to volumetric data, reduced cerebral blood flow in the lateral temporal regions was found in PD patients [ 34 ]. Our findings with respect to the association between overall cognitive performance and the lateral temporal volume are in concordance with a recent cross-sectional study of PD patients with a different cognitive disease stage [ 33 ] and another study with nondemented PD patients [ 32 ].…”