2010
DOI: 10.2967/jnumed.109.070144
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Combined Striatal Binding and Cerebral Influx Analysis of Dynamic 11C-Raclopride PET Improves Early Differentiation Between Multiple-System Atrophy and Parkinson Disease

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Cited by 41 publications
(32 citation statements)
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“…20 The radionuclides most commonly used for PET are 18 F and 11 C, which are produced using an accelerator. [21][22][23] Other metallic positron emitters, such as, 86 Y, 64 Cu, and 68 Ga also can be used for PET, [24][25][26][27][28][29][30] and of these, 68 Ga is the most promising, because it can be obtained using a commercially available generator system consisting of an inorganic matrix immobilizing the parent radionuclide 68 Ge. 31 This availability has led to great interest in the development of 68 Ga-labeled agents, because of its cost and convenience benefits.…”
Section: Introductionmentioning
confidence: 99%
“…20 The radionuclides most commonly used for PET are 18 F and 11 C, which are produced using an accelerator. [21][22][23] Other metallic positron emitters, such as, 86 Y, 64 Cu, and 68 Ga also can be used for PET, [24][25][26][27][28][29][30] and of these, 68 Ga is the most promising, because it can be obtained using a commercially available generator system consisting of an inorganic matrix immobilizing the parent radionuclide 68 Ge. 31 This availability has led to great interest in the development of 68 Ga-labeled agents, because of its cost and convenience benefits.…”
Section: Introductionmentioning
confidence: 99%
“…However, as demonstrated for other ligands (19,20), pharmacokinetic analyses of 11 C-PIB studies may yield diagnostically valuable estimates of relative regional CBF: Invasive compartment models used for 11 C-PIB quantification (21,22) provided estimates of K 1 (i.e., the rate constant for ligand transfer from arterial plasma to tissue). In radiotracers with a high permeability-surface product and, consequently, a high level of first-pass extraction, K 1 is closely related to CBF.…”
mentioning
confidence: 98%
“…Once a workflow is established, kinetic analyses can be accomplished by a trained user within 10-15 min. Finally, though not addressed in the present study, kinetic analyses such as SRTM2 and MRTM2 also provide an estimate of relative ligand delivery (R 1 ) that is proportional to relative cerebral blood flow and may thus serve as a diagnostically useful marker of regional neuronal activity and neurodegeneration (23,24).…”
Section: Discussionmentioning
confidence: 99%