2012
DOI: 10.2967/jnumed.112.103812
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Assessment of Striatal Dopamine D2/D3 Receptor Availability with PET and 18F-Desmethoxyfallypride: Comparison of Imaging Protocols Suited for Clinical Routine

Abstract: Assessment of striatal dopamine receptor availability with 18 F-desmethoxyfallypride PET is of high diagnostic utility in parkinsonism. The present study was undertaken to define the optimal clinical scan protocol with regard to quantification accuracy and scan time. Methods: Fourteen patients with parkinsonian syndromes underwent 18 F-desmethoxyfallypride PET over 90 min. Volume-of-interest analyses were performed after spatial normalization, with the right and left caudate nuclei and putamina as target regio… Show more

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(1 citation statement)
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“…Previous studies using SRTM2 for pharmacokinetic modeling employed different approaches for k ′ 2 estimation. For example, this parameter was evaluated by coupling all target time activity curves for radiotracers designed for D2/D3 receptors [17,18] and radioligands with a high affinity for the serotonin transporter [19]. Tracers such as [ 11 C]P943 [20], used for quantifying serotonin 5-HT1B receptors, use the median value of the k ′ 2 estimation for all voxels that have a BP SRTM ND value between 0.5 and 4, and [ 18 F]DPA-714 [21], used for neuroinflammation, the median of all k ′ 2 values from all voxels in the image.…”
Section: Introductionmentioning
confidence: 99%
“…Previous studies using SRTM2 for pharmacokinetic modeling employed different approaches for k ′ 2 estimation. For example, this parameter was evaluated by coupling all target time activity curves for radiotracers designed for D2/D3 receptors [17,18] and radioligands with a high affinity for the serotonin transporter [19]. Tracers such as [ 11 C]P943 [20], used for quantifying serotonin 5-HT1B receptors, use the median value of the k ′ 2 estimation for all voxels that have a BP SRTM ND value between 0.5 and 4, and [ 18 F]DPA-714 [21], used for neuroinflammation, the median of all k ′ 2 values from all voxels in the image.…”
Section: Introductionmentioning
confidence: 99%