2010
DOI: 10.1590/s0004-27302010000500008
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Abstract: Objective: To determine the normal values of serum IGF-1 (Immulite 2000) in a Brazilian adult (21-70 years) population. Subjects and methods: Healthy volunteers were divided into 10 groups according to age (5-year intervals), with 100 subjects (50 men and 50 women) per group. One-hundred participants were selected for repetition of the test after 12 weeks. Results: No difference in IGF-1 values was observed between men and women, but a progressive reduction of serum IGF-1 with age was seen. The reference value… Show more

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Cited by 49 publications
(60 citation statements)
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References 24 publications
(74 reference statements)
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“…In women and men with normal liver function, a similar situation was described by Yu et al (15). Other authors demonstrated no differences in S-IGF-1 values between men and women (17,45). Reports are also available which suggest slightly lower levels in females as compared to males (11).…”
Section: Discussionsupporting
confidence: 71%
“…In women and men with normal liver function, a similar situation was described by Yu et al (15). Other authors demonstrated no differences in S-IGF-1 values between men and women (17,45). Reports are also available which suggest slightly lower levels in females as compared to males (11).…”
Section: Discussionsupporting
confidence: 71%
“…Baseline leptin was already below 2 ng · ml −1 , which has been suggested as a threshold for leptin to exert suppressive effects on other endocrine axes (Holtkamp et al, 2003). However, baseline testosterone and IGF-1 concentrations were near the median of age-matched reference ranges (Rosario, 2010;Wang et al, 2008), which suggests that our participants did not show evidence of metabolic and endocrine suppression prior to the study start. It is further possible that the endocrine suppression during low energy availability was blunted by increased circulating concentrations of binding proteins, which were not assessed in this study.…”
Section: Discussionmentioning
confidence: 77%
“…No significant difference was observed between the experimental groups in terms of (29,30). Prospective epidemiologic studies have shown that high levels of IGFBP-3, independent of IGF-1, were associated with a lower risk of cancer and colorectal adenoma (3).…”
Section: Resultsmentioning
confidence: 99%