Normal range of alanine aminotransferase concentration is associated with carotid atherosclerosis

The association between non-alcoholic fatty liver disease and carotid atherosclerosis in subjects with within-reference range alanine aminotransferase levels

“…In Chinese adolescents (12-18 years), those in the highest ALT stratum within the normal range had more cardiovascular risk factors than those in the lower ALT strata [17]. A previous study by our group showed that ALT concentrations within the reference range were associated with increased C-IMT in healthy adults [18]. However, although serum ALT concentration is considered a marker of NAFLD, it is unclear whether elevated ALT level itself is sufficient to confirm the association between NAFLD and cardiovascular and metabolic disease or whether further evaluations, such as liver ultrasound, are needed.…”

“…Some studies have demonstrated that increased ALT, even within the reference range, may be related to increased risk of cardiovascular disease [17,18,29]. Accordingly, ALT concentrations currently regarded as within the normal range do not guarantee freedom from NAFLD and cardiovascular and metabolic disease; some authors have therefore suggested lowering the reference range of ALT.…”

Non‐alcoholic fatty liver disease's prevalence and impact on alanine aminotransferase associated with metabolic syndrome in the Chinese

“…A recent study also suggested that TG and ALT levels were strongly associated with advanced stages of NAFLD and NASH and could assist in the identification of NASH in an obesity surgery cohort 34 . In addition, emerging data highlight that the elevation in serum TG and ALT levels are independently correlated with atherosclerosis, and are associated with an increased risk of cardiovascular disease 17–19,35,36 . Apparently, there is an intercorrelation between TG and ALT.…”

“…[12][13][14] and has also been reported as a predictor of other mortalities 15,16 and incident cardiovascular disease. [17][18][19] Although higher ALT level is related to higher risk of NAFLD, the value of the concentration of serum ALT in diagnosis and prognosis of NAFLD remains to be determined, particularly in Chinese population.…”

Comparison of the Impact of Changes in Waist Circumference and Body Mass Index in Relation to Changes in Serum Gamma-Glutamyltransferase Levels

“…Recent studies have reported that gamma-glutamyltransferase (GGT) is related to an enhanced risk for subclinical atherosclerosis and coronary events 1,2) .…”