The association between non-alcoholic fatty liver disease and carotid atherosclerosis in subjects with within-reference range alanine aminotransferase levels

Kim, Kyung-Soo; Oh, Hyun-Ju; Kim, Dae Jung; Park, Seok Won; Cho, Yong‐Wook; Huh, Kap-Bum

doi:10.1507/endocrj.ej13-0269

Cited by 9 publications

(8 citation statements)

References 31 publications

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“…The variables contributing to this moderate level of accuracy included elevated AST and/or ALT, where risk progressively increased over a relatively restricted range (by quartile) considered “normal,” from <20 U/L to greater than 37 U/L. These data are consistent with that reported in other studies [ 21 ] and a progressive but low level of hepatocyte injury due to triglyceride accumulation. Older age also had a slight effect on risk, consistent with previous studies [ 9 ].…”

Section: Discussionsupporting

confidence: 88%

Identification of Novel Clinical Factors Associated with Hepatic Fat Accumulation in Extreme Obesity

et al. 2014

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Objectives. The accumulation of lipids stored as excess triglycerides in the liver (steatosis) is highly prevalent in obesity and has been associated with several clinical characteristics, but most studies have been based on relatively small sample sizes using a limited set of variables. We sought to identify clinical factors associated with liver fat accumulation in a large cohort of patients with extreme obesity. Methods. We analyzed 2929 patients undergoing intraoperative liver biopsy during a primary bariatric surgery. Univariate and multivariate regression modeling was used to identify associations with over 200 clinical variables with the presence of any fat in the liver and with moderate to severe versus mild fat accumulation. Results. A total of 19 data elements were associated with the presence of liver fat and 11 with severity of liver fat including ALT and AST, plasma lipid, glucose, and iron metabolism variables, several medications and laboratory measures, and sleep apnea. The accuracy of a multiple logistic regression model for presence of liver fat was 81% and for severity of liver fat accumulation was 77%. Conclusions. A limited set of clinical factors can be used to model hepatic fat accumulation with moderate accuracy and may provide potential mechanistic insights in the setting of extreme obesity.

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Section: Discussionsupporting

confidence: 88%

Identification of Novel Clinical Factors Associated with Hepatic Fat Accumulation in Extreme Obesity

et al. 2014

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“…According to one study, cirrhosis was present when serum AST level went higher than serum ALT level and when the ratio AST/ALT exceeded 1 (Anglo et al, 1999). Additionally, it has been reported that NAFLD is considered a direct cause for mild aminotransferase elevation (Diehl et al, 1988;Kim et al, 2013), and that improvement in ALT levels may indicate improvement in steatosis and inflammation but not advanced fibrosis (Adams et al, 2005). Based on these findings, our model is a steatohepatitis model that did not progress to cirrhosis, in which liver was significantly protected by all treatment agents and their combinations.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of ursodeoxycholic acid, resveratrol, andN-acetylcysteine on nonalcoholic fatty liver disease in rats

Ali

Messiha

Abdellatif

2015

Pharmaceutical Biology

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(2016) Protective effect of ursodeoxycholic acid, resveratrol, and Nacetylcysteine on nonalcoholic fatty liver disease in rats, Pharmaceutical Biology, 54:7, 1198-1208, DOI: 10.3109/13880209.2015 -a), glucose, albumin, renal functions (urea, creatinine), lipid profile (total cholesterol; TC, triglycerides, high density lipoproteins, low density lipoproteins; LDL-C, very low density lipoproteins, leptin), and oxidative stress markers (hepatic malondialdehyde; MDA, glutathione; GSH, glutathione-S-transferase; GST) were measured using automatic analyzer, colorimetric kits, and ELISA kits, supported by a liver histopathological study.Results: RSV and NAC administration significantly improved liver index (RSV only), alanine transaminase (52, 52%), TNF-a (70, 70%), glucose (69, 80%), albumin (122, 114%), MDA (55, 63%), GSH (160, 152%), GST (84, 84%), TC (86, 86%), LDL-C (83, 81%), and leptin (59, 70%) levels compared with steatosis control values. A combination of RSV or NAC with UDCA seems to ameliorate their effects. Discussion and conclusion: RSV and NAC are effective on NAFLD through antioxidant, antiinflammatory, and lipid-lowering potentials, where as RSV seems better than UDCA or NAC.

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“…Importantly, the severity of the histological features of NAFLD appear to be independently correlated with increasing C-IMT 9 . Several cross-sectional studies 10 11 12 13 have shown that NAFLD is strongly associated with increased C-IMT and increased coronary artery calcium scores in nondiabetic patients and in those with T2DM, although not all studies have agreed with these findings 14 15 . Moreover, studies have suggested that preclinical CVD (such as C-IMT, plaque, and endothelial dysfunction) are seen more frequently and to a greater extent in patients with T1DM, even at an early age.…”

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confidence: 99%

Nonalcoholic Fatty Liver Disease is Associated with Increased Carotid Intima-Media Thickness in Type 1 Diabetic Patients

Zhang

Guo

et al. 2016

Sci Rep

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A growing body of evidence suggests that NAFLD is associated with an increased risk of incident CVD events both in patients without diabetes and in those with type 2 diabetes (T2DM). However, no published data are available regarding the association between NAFLD and C-IMT in T1DM. A total of 722 patients (371 men) with T1DM were included in this cross-sectional study. The main outcome measures were detection of NAFLD, C-IMT and classical risk factors. The mean age of the subjects was 46.2 years, and 51.1% were male. The prevalence of NAFLD was 15.9%. NAFLD patients had a markedly greater C-IMT (0.81 ± 0.25 vs. 0.69 ± 0.18 mm; p < 0.001) and frequency of carotid plaque (28.9% vs. 16.9%; p < 0.05) than those without fatty liver. Moreover, the differences in C-IMT remained after adjusting for potential confounders. A stepwise linear regression analysis revealed that age (standardized β, 0.326; p < 0.001), NAFLD (standardized β, 0.151, p < 0.001), and hsCRP (standardized β, 0.115, p = 0.008) were independently associated with C-IMT in all subjects. Our data show NAFLD is associated with elevated C-IMT in T1DM independent of conventional cardiovascular disease risk factors.

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The association between non-alcoholic fatty liver disease and carotid atherosclerosis in subjects with within-reference range alanine aminotransferase levels

Cited by 9 publications

References 31 publications

Identification of Novel Clinical Factors Associated with Hepatic Fat Accumulation in Extreme Obesity

Identification of Novel Clinical Factors Associated with Hepatic Fat Accumulation in Extreme Obesity

Protective effect of ursodeoxycholic acid, resveratrol, andN-acetylcysteine on nonalcoholic fatty liver disease in rats

Nonalcoholic Fatty Liver Disease is Associated with Increased Carotid Intima-Media Thickness in Type 1 Diabetic Patients

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