Norfloxacin La(III)-based complex: synthesis, characterization, and DNA-binding studies

Quinolones comprise a series of synthetic bactericidal agents with a broad spectrum of activity and good bioavailability. An important feature of these molecules is their capacity to bind metal ions in complexes with relevant biological and analytical applications. Interestingly, lanthanide ions possess extremely attractive properties that result from the behavior of the internal 4f electrons, behavior which is not lost upon ionization, nor after coordination. Subsequently, a more detailed discussion about metal complexes of quinolones with lanthanide ions in terms of chemical and biological properties is made. These complexes present a series of characteristics, such as narrow and highly structured emission bands; large gaps between absorption and emission wavelengths (Stokes shifts); and long excited-state lifetimes, which render them suitable for highly sensitive and selective analytical methods of quantitation. Moreover, quinolones have been widely prescribed in both human and animal treatments, which has led to an increase in their impact on the environment, and therefore to a growing interest in the development of new methods for their quantitative determination. Therefore, analytical applications for the quantitative determination of quinolones, lanthanide and miscellaneous ions and nucleic acids, along with other applications, are reviewed here.

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“…-the complex shows moderate interaction with CT-DNA, by partial or non-intercalative binding modes. [54] Ofloxacin (OFLO)…”

Section: Biological Activity Of Metal Complexes Of Quinolones With Lamentioning

confidence: 99%

Quinolone Complexes with Lanthanide Ions: An Insight into their Analytical Applications and Biological Activity

2020

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“…Lanthanum(III) complexes have been employed in various biological and as well as photophysical applications. La (III) complexes with quercetin [11], Schiff bases [12], oxamides [13], norfloxacin [14], derivatives of phenanthroline have been employed as chemical nucleases [15], DNA binding agents [16], antimicrobial [13] and anticancer agents [7,11]. Lanthanum(III) complexes have also shown ligand dependent photoluminescence properties [17,18].…”

Section: Studies On Dna Interactions and Biological Activities Of Lanmentioning

confidence: 99%

Studies on DNA Interactions and Biological Activities of Lanthanum(III) Complexes with 4-Quinoline Terpyridine and 1,10-Phenanthroline

et al. 2019

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A series of lanthanum(III) complexes [La(4-qtpy)2(NO3)2](NO3) (1), [La(4-qtpy)3(NO3)](NO3)2 (2), [La(4-qtpy)(phen)(NO3)2](NO3) (3) and [La(4-qtpy)(phen)2(NO3)2](NO3) (4) (4-qtpy = 4′-[(4-quinoline)-2,2′;6′,2′′-terpyridine]) were synthesized and characterized. The cyclic voltammetric studies revealed that the complexes 1 and 3 are redox active. UV-visible absorption spectral studies and viscosity measurements revealed that complexes bind to DNA through intercalation. Complexes 1 and 3 have shown the highest binding propensity (Kb = 4.241 + 0.2 × 106 for 1 and 1.492 + 0.2 × 106 for 3). The results of chemical nuclease studies revealed that the complexes 3 and 4 have shown maximum chemical nuclease activity in the presence of H2O2 and the mechanism involves hydroxyl radicals. The antibacterial activities of the complexes 1 to 4 were tested against Gram positive and Gram negative bacteria in which complex 3 shows comparable results with the standard antibiotic tetracycline. The cytotoxic activities of 4-qtpy and complex 4 were done by MTT assay against HeLa cell lines.

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Synthesis, characterization, in vitro biological evaluation and molecular docking studies of newly synthesized mononuclear lanthanum(III) complexes of N,N'-bis(2-aminoethyl)oxamide and phenanthroline bases

Bhat

Chetana

Dhale

et al. 2022

Journal of Molecular Structure

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Norfloxacin La(III)-based complex: synthesis, characterization, and DNA-binding studies

Cited by 7 publications

References 34 publications

Quinolone Complexes with Lanthanide Ions: An Insight into their Analytical Applications and Biological Activity

Quinolone Complexes with Lanthanide Ions: An Insight into their Analytical Applications and Biological Activity

Studies on DNA Interactions and Biological Activities of Lanthanum(III) Complexes with 4-Quinoline Terpyridine and 1,10-Phenanthroline

Synthesis, characterization, in vitro biological evaluation and molecular docking studies of newly synthesized mononuclear lanthanum(III) complexes of N,N'-bis(2-aminoethyl)oxamide and phenanthroline bases

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