Nontransient silk sandwich for soft, conformal bionic links

Patil, Anoop C.; Bandla, Aishwarya; Liu, Yu Hang; Luo, Baiwen; Thakor, Nitish V.

doi:10.1016/j.mattod.2019.08.007

Cited by 29 publications

(41 citation statements)

References 53 publications

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“…[ 13 ] Aqueous silk can be drop‐cast and dried to obtain thin films of silk with thickness values in the micrometer scale or spin‐coated to obtain submicron thick films. [ 13,14,78 ] Pristine dry silk is dissolvable in aqueous media, and plastic in nature much like conventional plastic polymers such as parylene and polyimide. In comparison, water‐annealed silk is nontransient, soft, and flexible with Young's modulus in the MPa scale.…”

Section: New Opportunities For Silk Fibroinmentioning

confidence: 99%

“…In comparison, water‐annealed silk is nontransient, soft, and flexible with Young's modulus in the MPa scale. [ 78 ] The aqueous silk fibroin serves as the starting material for all of the silk‐based fabrication methodologies discussed here and provides many degrees of freedom to exploit the material properties of silk protein in the design of implantable sensors and devices.…”

Section: New Opportunities For Silk Fibroinmentioning

confidence: 99%

“…Recently, water stable nontransient silk in the form of highly bendable and flexible films along with sensing metal layer and conductive traces were used to develop bionic link implants. [ 78 ] These sensors were wrapped tightly around challenging nerve geometries and laminated onto planar cortical surfaces, assisting in the electrical recording of neural activity from the target tissue surfaces ( Figure a). The fabrication flow involved the green assembly of a thin metalized silk layer and a patterned bare silk layer to form a flexible and bendable silk sandwich (Figure 9b,c) and subsequent water‐annealing of the sandwich to realize a nontransient silk sensor implant.…”

Section: Nontransient Silk: a Materials Candidate For The Soft Bionic mentioning

confidence: 99%

“…Even though there had been research studies on the sustainability of pristine silk films in an animal model, functional water‐stable silk interfaces to the tissues had not been realized until recently. [ 78 ]…”

Section: Nontransient Silk: a Materials Candidate For The Soft Bionic mentioning

confidence: 99%

“…The complexity of the bilayered silk sandwich sensor [ 78 ] can be perceived in terms of manufacturing technology required to enable nontransient sandwich constructs and the interdependencies between the fabrication steps and the integrity of silk components. For example, the complexity of preparing a silk sandwich increases with thinner substrate films given the dry brittle nature of non‐annealed pristine silk.…”

Section: Nontransient Silk: a Materials Candidate For The Soft Bionic mentioning

confidence: 99%

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Toward Nontransient Silk Bioelectronics: Engineering Silk Fibroin for Bionic Links

2020

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He maintains his position as a Professor of Biomedical Engineering, Electrical and Computer Engineering, and Neurology at Johns Hopkins University in USA. His technical expertise is in the field of neuroengineering, including neural instrumentation, neuromorphic engineering, neural microsystems, optical imaging of the nervous system, neural control of prosthesis, brain-machine interfaces, and cognitive engineering.

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Section: New Opportunities For Silk Fibroinmentioning

confidence: 99%

Section: New Opportunities For Silk Fibroinmentioning

confidence: 99%

Section: Nontransient Silk: a Materials Candidate For The Soft Bionic mentioning

confidence: 99%

Section: Nontransient Silk: a Materials Candidate For The Soft Bionic mentioning

confidence: 99%

Section: Nontransient Silk: a Materials Candidate For The Soft Bionic mentioning

confidence: 99%

See 3 more Smart Citations

Toward Nontransient Silk Bioelectronics: Engineering Silk Fibroin for Bionic Links

2020

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Challenges and Opportunities of Implantable Neural Interfaces: From Material, Electrochemical and Biological Perspectives

Zeng

Huang

2023

Adv Funct Materials

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The desirable implantable neural interfaces can accurately record bioelectrical signals from neurons and regulate neural activities with high spatial/time resolution, facilitating the understanding of neuronal functions and dynamics. However, the electrochemical performance (impedance, charge storage/injection capacity) is limited with the miniaturization and integration of neural electrodes. The “crosstalk” caused by the uneven distribution of elctric field leads to lower electrical stimulation/recording efficiency. The mismatch between stiff electrodes and soft tissues exacerbates the inflammatory responses, thus weakening the transmission of signals. Though remarkable breakthroughs have been made through the incorporation of optimizing electrode design and functionalized nanomaterials, the chronic stability, and long‐term activity in vivo of the neural electrodes still need further development. In this review, the neural interface challenges mainly on electrochemistry and biology are discussed, followed by summarizing typical electrode optimization technologies and exploring recent advances in the application of nanomaterials, based on traditional metallic materials, emerging 2D materials, conducting polymer hydrogels, etc., for enhancing neural interfaces. The strategies for improving the durability including enhanced adhesion and minimized inflammatory response, are also summarized. The promising directions are finally presented to provide enlightenment for high‐performance neural interfaces in future, which will promote profound progress in neuroscience research.

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Highly Stretchable Metal–Polymer Conductor Electrode Array for Electrophysiology

Dong

Liu

Cheng

et al. 2020

Adv Healthcare Materials

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Narrowing the mechanical mismatch between biological tissues (typically soft) and neural interfaces (hard) is essential for maintaining signal quality for the electrical recording of neural activity. However, only a few materials can satisfy all requirements for such electronics, which need to be both biocompatible and sufficiently soft. Here, a highly stretchable electrode array (SEA) is introduced, based on the liquid metal–polymer conductor (MPC), achieving high mechanical flexibility and good cytocompatability for neural interfaces. By utilizing the MPC, the SEA exhibits high stretchability (≈100%) and excellent cycling stability (>400 cycles). The cytocompatability of the SEA can allow for long‐term culturing of primary neurons and enable signal recording of primary hippocampal neurons. In the future, the SEA could serve as a reliable and robust platform for diagnostics in neuronal tissues and greatly advance brain–machine interfaces.

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Nontransient silk sandwich for soft, conformal bionic links

Cited by 29 publications

References 53 publications

Toward Nontransient Silk Bioelectronics: Engineering Silk Fibroin for Bionic Links

Toward Nontransient Silk Bioelectronics: Engineering Silk Fibroin for Bionic Links

Challenges and Opportunities of Implantable Neural Interfaces: From Material, Electrochemical and Biological Perspectives

Highly Stretchable Metal–Polymer Conductor Electrode Array for Electrophysiology

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