Toward Nontransient Silk Bioelectronics: Engineering Silk Fibroin for Bionic Links

Patil, Anoop C.; Xiong, Ze; Thakor, Nitish V.

doi:10.1002/smtd.202000274

Cited by 30 publications

(17 citation statements)

References 133 publications

(274 reference statements)

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“…However, the helium leak test can be misleading in the case of a polymer package (Vanhoestenberghe and Donaldson, 2011 ). Therefore, many researchers started to choose moisture permeability as the standard for quantifying the hermeticity of the packaging (Sim et al, 2017 ; Bettinger et al, 2020 ; Patil et al, 2020 ; Song et al, 2020 ). In theory, all materials will leak to some extent (Ely, 2000 ) but with different permeabilities.…”

Section: Packaging and Substrate Materialsmentioning

confidence: 99%

A Review: Electrode and Packaging Materials for Neurophysiology Recording Implants

Yang

Gong

2021

Front. Bioeng. Biotechnol.

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To date, a wide variety of neural tissue implants have been developed for neurophysiology recording from living tissues. An ideal neural implant should minimize the damage to the tissue and perform reliably and accurately for long periods of time. Therefore, the materials utilized to fabricate the neural recording implants become a critical factor. The materials of these devices could be classified into two broad categories: electrode materials as well as packaging and substrate materials. In this review, inorganic (metals and semiconductors), organic (conducting polymers), and carbon-based (graphene and carbon nanostructures) electrode materials are reviewed individually in terms of various neural recording devices that are reported in recent years. Properties of these materials, including electrical properties, mechanical properties, stability, biodegradability/bioresorbability, biocompatibility, and optical properties, and their critical importance to neural recording quality and device capabilities, are discussed. For the packaging and substrate materials, different material properties are desired for the chronic implantation of devices in the complex environment of the body, such as biocompatibility and moisture and gas hermeticity. This review summarizes common solid and soft packaging materials used in a variety of neural interface electrode designs, as well as their packaging performances. Besides, several biopolymers typically applied over the electrode package to reinforce the mechanical rigidity of devices during insertion, or to reduce the immune response and inflammation at the device-tissue interfaces are highlighted. Finally, a benchmark analysis of the discussed materials and an outlook of the future research trends are concluded.

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Section: Packaging and Substrate Materialsmentioning

confidence: 99%

A Review: Electrode and Packaging Materials for Neurophysiology Recording Implants

Yang

Gong

2021

Front. Bioeng. Biotechnol.

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“…In terms of biological electronics, the biointegrated devices derived from the combination of soft biological materials and hard inorganic materials provide a new material platform contained unique advantages for electronics, such as flexibility, robustness, biocompatibility, and biodegradability. [ 135,136 ] The development of biological electronics is a critical step to meet the requirements of pharmaceutical science, wearable devices, implantable chips, and neural interfaces since these applications usually involve unconventional interfaces that are not suitable for traditional silicon‐based electronics. [ 137,138 ] In recent years, researchers have devoted massive efforts to conductive polymers because of their electronic properties, biocompatibility, and interface properties, which provide a promising avenue for flexible and transient systems.…”

Section: Applications Of Biopolymer Patternsmentioning

confidence: 99%

Recent Advances in Patterning Natural Polymers: From Nanofabrication Techniques to Applications

et al. 2021

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The development of a flexible and efficient strategy to precisely fabricate polymer patterns is increasingly significant for many research areas, especially for cell biology, pharmaceutical science, tissue engineering, soft photonics, and bioelectronics. Recent advances of patterning natural polymers using various nanofabrication techniques, including photolithography, electron‐beam lithography, dip‐pen nanolithography, inkjet printing, soft lithography, and nanoimprint lithography are discussed here. Integrating nanofabrication techniques with naturally derived macromolecules provides a feasible route for transforming these polymer materials into versatile and sophisticated devices while maintaining their intrinsic and excellent properties. Furthermore, the corresponding applications of these natural polymer patterns generated by the above techniques are elaborated. In the end, a summary of this promising research field is offered and an outlook for the future is given. It is expected that advances in precise spatial patterns of natural polymers would provide new avenues for various applications, such as tissue engineering, flexible electronics, biomedical diagnosis, and soft photonics.

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“…(d) Silk-based NI wrapped around the sciatic nerve (right) to record the electrical signal at two different points (left). (e) Comparative cortical activity recorded by silk-based cortical electrodes prior to (left) and post (right) ischemia induction (Reproduced with permission from [Patil et al 2020a , b ] © 2020 John Wiley & Sons, Inc.) …”

Section: State Of the Artmentioning

confidence: 99%

“…In another interesting work in the context of NMs as building blocks of NIs, nontransient silk electrodes were used for neural recording (Patil et al 2020a , b ). In this study, a smart process used to modify the traditional microfabrication technique conferred NM with adaptability for integration, with silk used as a water-stable insulating layer.…”

Section: State Of the Artmentioning

confidence: 99%

“…Water annealing was used to achieve a water-stable nontransient silk NI, and subsequent conductive layer deposition led to the formation of a flexible silk electrode. Experiments on material stability in physiological environments and animal tests illustrated the remarkable potential of this electrode as a sensing interface for neural signal recording in either the cortex or peripheral nervous system (Patil et al 2020a , b ). This type of nontransient NM-based electrode and the great potential of NMs to the pursuit of the biocompatibility enhancement could represent a turning point in NIs long term reliability.…”

Section: State Of the Artmentioning

confidence: 99%

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Progress and challenges of implantable neural interfaces based on nature-derived materials

Riva

Micera

2021

Bioelectron Med

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Neural interfaces are bioelectronic devices capable of stimulating a population of neurons or nerve fascicles and recording electrical signals in a specific area. Despite their success in restoring sensory-motor functions in people with disabilities, their long-term exploitation is still limited by poor biocompatibility, mechanical mismatch between the device and neural tissue and the risk of a chronic inflammatory response upon implantation.In this context, the use of nature-derived materials can help address these issues. Examples of these materials, such as extracellular matrix proteins, peptides, lipids and polysaccharides, have been employed for decades in biomedical science. Their excellent biocompatibility, biodegradability in the absence of toxic compound release, physiochemical properties that are similar to those of human tissues and reduced immunogenicity make them outstanding candidates to improve neural interface biocompatibility and long-term implantation safety. The objective of this review is to highlight progress and challenges concerning the impact of nature-derived materials on neural interface design. The use of these materials as biocompatible coatings and as building blocks of insulation materials for use in implantable neural interfaces is discussed. Moreover, future perspectives are presented to show the increasingly important uses of these materials for neural interface fabrication and their possible use for other applications in the framework of neural engineering.

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Toward Nontransient Silk Bioelectronics: Engineering Silk Fibroin for Bionic Links

Cited by 30 publications

References 133 publications

A Review: Electrode and Packaging Materials for Neurophysiology Recording Implants

A Review: Electrode and Packaging Materials for Neurophysiology Recording Implants

Recent Advances in Patterning Natural Polymers: From Nanofabrication Techniques to Applications

Progress and challenges of implantable neural interfaces based on nature-derived materials

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