Nonspecificity of the bronchoconstricting effect of histamine and acetyl-beta-methylcholine in patients with obstructive airway disease

Increasing doses of histamine, 0.00025-0.001 mg of the phosphate/kg body weight, were given intravenously to five normal subjects, seven asthmatics and five chronic bronchitics. Changes in specific airway conductance (SGaw) were measured with a body plethysmograph.In all groups there was significant depression of SGaw following injection of all three doses of histamine but no group was significantly different from another.It is concluded that bronchial reactivity to intravenous injection of histamine does not provide a diagnostic test for separating chronic bronchitis from asthmatics.

Section: Discussionsupporting

confidence: 75%

The Effect of Intravenous Histamine on Specific Airway Conductance in Patients with Airway Obstruction and in Normal Subjects

Epstein¹,

Warrell²,

Robertson³

et al. 1970

“…However, normal subjects are less likely to show bronchospasm in response to these substances than atopic individuals or patients with CNSLD [Klein and Salvaggio, 1966;Lecomte and Petit, 1960;M arino, 1966;M arcelli et al, 1965;Rebohle and Jager, 1968].…”

Section: Discussionmentioning

confidence: 99%

Response to Inhaled Histamine and to Inhaled Allergens in Atopic Patients

Kreukniet¹,

Pijper²

1973

In atopic patients with chronic non specific lung diseases, the sensitivity of the bronchial tree to histamine and to allergens was studied by means of inhalation provocation tests. An unmistests takable correlation was demonstrated between the results of histamine inhalation provocation tests tests (HIPT) and allergen inhalation provocation tests (AIPT).When the HIPT revealed a higher sensitivity to histamine, the AIPT disclosed a higher sensitivity to allergens. This was manifested by the larger number of allergens to which the patients reacted at AIPT, as well as by the severity of the reaction after AIPT, as measured spirographically. Moreover, higher sensitivity to histamine was associated with more late positive reactions after AIPT

“…This suggests no major individual differences in the sensitivity of the systemic circulations [Curry, 1946;Dowell et al, 1966;Klein and Salvaggio, 1966].…”

Section: Discussionmentioning

confidence: 94%

Effect of Intravenous Histamine, Allergen <i>(Ascaris suum</i> Extract) and Compound 48/80 and Inhaled Allergen-Aerosol on Bronchoconstriction and Histamine Release

Zimmermann¹,

Ulmer²

1981

The effect of a histamine releaser (48/80), an antigen (Ascaris suum extract) and of exogenous histamine infusion on antigen aerosol-induced bronchoconstriction was investigated in 24 mongrel dogs. During these substance infusions, the high values of arterial plasma histamine did not correlate with the degree of bronchoconstriction. Further, a severe bronchoconstriction with a relatively low arterial plasma histamine concentration was observed during antigen inhalation. During substance inhalation, a high local concentration of histamine is assumed to explain the increased bronchial ‘sensitivity’ to actual plasma levels of histamine. Also, the responsiveness of the bronchial tree to antigen aerosol was observed to be reduced 90 min after induction of a strong histamine release. The importance of histamine in the first phase of immediate hypersensitivity is discussed.