Response to Inhaled Histamine and to Inhaled Allergens in Atopic Patients

Kreukniet, J.; Pijper, M.M.

doi:10.1159/000193049

Cited by 16 publications

(3 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the laboratory allergen challenge can produce an increase in bronchial reactivity9-1 and the airway response to allergen can be predicted from a prior knowledge of the histamine PD20. [20][21][22][23] We also found, as in a previous study,'3 an interaction between age and atopy with a significant reduction in the proportion of atopic subjects with measurable PD20 values with increasing age.…”

Section: Discussionsupporting

confidence: 85%

Factors affecting peak expiratory flow variability and bronchial reactivity in a random population sample.

Higgins

Britton²,

Chinn³

et al. 1993

Thorax

View full text Add to dashboard Cite

Results-A total of 273 subjects (69%) collected a PEF meter but a completed record sheet was returned by only 247 (62%); this was still significantly more than the 202 subjects (54%) who attended for and successfully completed a challenge test. Amplitude % mean was higher in women than in men (9.7% v 8.5%). In multiple regression analysis amplitude % mean increased significantly with age, mean skin weal diameter, and with current smoking. The odds of having a PD20 below 24 5,umol increased with mean skin weal diameter and were greater in current smokers. Neither age nor sex had a significant effect on bronchial reacitvity but there were significant interactions between age and the effects of both smoking and atopy. Conclusions-The higher response rate associated with the use of PEF variability measurement, and the association with factors implicated in the pathogenesis of airways disease, suggest that PEF variability would be a useful measurement to employ in epidemiological studies. (Thorax 1993;48:899-905)

show abstract

Section: Discussionsupporting

confidence: 85%

Factors affecting peak expiratory flow variability and bronchial reactivity in a random population sample.

Higgins

Britton²,

Chinn³

et al. 1993

Thorax

View full text Add to dashboard Cite

show abstract

“…A similar, perfectly consistent sequence of allergen reactivities has recently been described by K reukniet and P ijper [22], who performed bronchial challenge tests with a large number of allergens in atopic patients. These authors also reported a significant positive correlation between histamine reactivity of the bronchial tree and the number of positive reactions to various inhaled al lergens, with the exception of pollen.…”

Section: Diagnostic Extractssupporting

confidence: 73%

Plural Actions of Allergens

Berrens¹

1975

Int Arch Allergy Immunol

View full text Add to dashboard Cite

“…Other workers have noted an association between the bronchial reactivity of asthmatic patients to histamine and to extracts of house dust and grass pollen (Lookeren Campagne, Krol & De Vries, 1969;Kreukniet & Pijper, 1973) but no attempt was made in those studies to examine the strength of this association or to look for a similar association in atopic non-asthmatic subjecls such as was done in the present study. The results reported here indicate that, in subjects producing IgE specific for inhalant allergens, regardless of whether this antibody was associated with clinical symptoms or not, that those whose bronchi were most reactive to inhaled allergen tended to be most reactive to histamine.…”

Section: Discussionmentioning

confidence: 61%

Bronchial histamine reactivity: its relationship to the reactivity of the bronchi to allergens

Bryant

Burns

1976

Clin Experimental Allergy

View full text Add to dashboard Cite

The aim of this study was to examine the proposal that the magnitude ofthe response of the bronchi to an immediate allergic reaction depends not only on the degree of sensitization ofthe bronchi by allergen specific IgE antibody but also on the reactivity of the bronchi to the vasoactive mediators which are released during immediate allergic reactions. This was done by determining the bronchial reactivity to Dermatophagoides pteronyssinus and to histamine of both symptomatic and asymptomatic groups of atopic subjects who had comparable serum levels of D. pteronyssinus specific IgE. Positive bronchial responses to the D. pteronyssinus extract were recorded with both tbe symptomatic and asymptomatic subjects, the mean bronchial threshold dose of allergen being significantly higher in the asymptomatic than in the asthmatic patients. There was a highly significant correlation between the serum level of allergen specific IgE and the bronchial threshold dose of allergen extract and also between the bronchial threshold dose of allergen extract and of histamine in all groups of subjects. The ability to predict bronchia! reactivity to the allergen from the serum level of allergen specific IgE within each group was significantly better if the bronchial reactivity to histamine was included in the correlation analysis. This supports the hypothesis that whether a particular subject who is producing specific IgE antibody will develop symptoms on the inhalation of that allergen depends not only on the amount of allergen which he inhales and on the degree of sensitization of his bronchi but also on the reactivity of his bronchi to the vasoactive mediators which are released by allergen-IgE inleraction.

show abstract

Response to Inhaled Histamine and to Inhaled Allergens in Atopic Patients

Cited by 16 publications

References 12 publications

Factors affecting peak expiratory flow variability and bronchial reactivity in a random population sample.

Factors affecting peak expiratory flow variability and bronchial reactivity in a random population sample.

Plural Actions of Allergens

Bronchial histamine reactivity: its relationship to the reactivity of the bronchi to allergens

Contact Info

Product

Resources

About