Nonlinear and anisotropic tensile properties of graft materials used in soft tissue applications

Yoder, Jonathon H.; Elliott, Dawn M.

doi:10.1016/j.clinbiomech.2010.01.004

Cited by 27 publications

(18 citation statements)

References 46 publications

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“…The superiority of mechanical behaviour (both in terms of UTS and E) of specimens cut along mediolateral direction compared to the specimens cut along craniocaudal direction, is confirmed by Annaidh et al [11]. Besides Young's modulus data here calculated fall within the variability of the allograft results as reported by Yoder and Elliott [12].…”

Section: Resultssupporting

confidence: 77%

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Dermis mechanical behaviour: influence of cell removal treatment

Audenino¹,

Bignardi²,

Businaro³

et al. 2013

Modelling in Medicine and Biology X

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The mechanical behaviour of skin is very important as regards dermatology, surgery and impact trauma. Engineered skin substitutes can bring significant medical benefit, in particular to patients with extensive burn wounds, even if current skin substitutes do not restore normal skin anatomy and its natural mechanical properties. This work considers the mechanical characterization of a particular layer of skin: dermis. Dermis can be used as a filling material and as support in different areas of reconstructive plastic surgery such as post mastectomy reconstructive surgery and abdominal surgery. The aim was to verify the influence of the decellularization treatment on its properties. The specimens were subjected to uniaxial static tests performed with Bose Electroforce ® 3200 and experimental data were represented with engineering and real time stress-strain curves. To begin, descriptive parameters were identified for stress vs. strain curves, such as ultimate tensile strength and maximum Young's modulus, and they were subsequently compared through multivariate analysis of variance to determine the influence of specimen cut orientation and decellularization treatment duration. Dermis, that had been decellularized over 5 or 6 weeks, exhibited mechanical properties comparable with natural ones and ultimate tensile strength and maximum Young's modulus were shown to be considerably higher in real time curves than in engineering ones.

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Section: Resultssupporting

confidence: 77%

“…Other authors make use of 'real time' curves specimen cross section and length are measured in real time (Yoder and Elliott. [12]). In this work, both representations have been reported.…”

Section: Elaboration Datamentioning

confidence: 99%

Dermis mechanical behaviour: influence of cell removal treatment

Audenino¹,

Bignardi²,

Businaro³

et al. 2013

Modelling in Medicine and Biology X

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“…26,27 This is reflected in the modulus of elasticity of HAD, $0.01 GPa. 28 In comparison the elasticity of OFM (0.044 6 0.009 GPa) was shown to be comparable with the reported modulus of SIS (0.026 6 0.014 GPa). 29 Biophysical testing of the OFM biomaterial additionally demonstrated that this native dECM is relatively strong (yield stress, 10.15 6 1.81 MPa) and is 31 and SIS (20.32 6 1.88 N).…”

Section: Discussionsupporting

confidence: 80%

“…Anisotropy is also evident in multi-ply SIS biomaterials and HAD. 28 A benefit of laminating dECM-based biomaterials is that the process of lamination has the potential to average any morphological differences seen in the materials. In this way, local biophysical differences within a sheet of material, or differences between two sheets of material are averaged out to increase homogeneity.…”

Section: Discussionmentioning

confidence: 99%

Biophysical characterization of ovine forestomach extracellular matrix biomaterials

Floden¹,

Malak

Basil-Jones

et al. 2010

J Biomed Mater Res

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Ovine forestomach matrix (OFM) is a native and functional decellularized extracellular matrix biomaterial that supports cell adhesion and proliferation and is remodeled during the course of tissue regeneration. Small angle X-ray scattering demonstrated that OFM retains a native collagen architecture (d spacing = 63.5 ± 0.2 nm, orientation index = 20°). The biophysical properties of OFM were further defined using ball-burst, uniaxial and suture retention testing, as well as a quantification of aqueous permeability. OFM biomaterial was relatively strong (yield stress = 10.15 ± 1.81 MPa) and elastic (modulus = 0.044 ± 0.009 GPa). Lamination was used to generate new OFM-based biomaterials with a range of biophysical properties. The resultant multi-ply OFM biomaterials had suitable biophysical characteristics for clinical applications where the grafted biomaterial is under load.

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“…11,[17][18][19] However, there are no known studies that have examined both the nonlinear elastic properties using an Ogden model and morphology of either AlloDerm or engineered mucosal tissues.…”

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confidence: 99%

Characterizing Morphology and Nonlinear Elastic Properties of Normal and Thermally Stressed Engineered Oral Mucosal Tissues Using Scanning Acoustic Microscopy

Winterroth

Hollman

Kuo

et al. 2013

Tissue Engineering Part C: Methods

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This study examines the use of high-resolution ultrasound to monitor changes in the morphology and nonlinear elastic properties of engineered oral mucosal tissues under normal and thermally stressed culture conditions. Nonlinear elastic properties were determined by first developing strain maps from acoustic ultrasound, followed by fitting of nonlinear stress-strain data to a 1-term Ogden model. Testing examined a clinically developed ex vivo produced oral mucosa equivalent (EVPOME). As seeded cells proliferate on an EVPOME surface, they produce a keratinized protective upper layer that fills in and smoothens out surface irregularities. These transformations can also alter the nonlinear stress/strain parameters as EVPOME cells differentiate. This EVPOME behavior is similar to those of natural oral mucosal tissues and in contrast to an unseeded scaffold. If ultrasonic monitoring could be developed, then tissue cultivation could be adjusted in-process to account for biological variations in their development of the stratified cellular layer. In addition to ultrasonic testing, an inhouse-built compression system capable of accurate measurements on small (*1.0-1.5 cm 2 ) tissue samples is presented. Results showed a near 2.5-fold difference in the stiffness properties between the unstressed EVPOME and the noncell-seeded acellular scaffold (AlloDerm Ò ). There were also 4 · greater differences in root mean square values of the thickness in the unseeded AlloDerm compared to the mature unstressed EVPOME; this is a strong indicator for quantifying surface roughness.

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Nonlinear and anisotropic tensile properties of graft materials used in soft tissue applications

Cited by 27 publications

References 46 publications

Dermis mechanical behaviour: influence of cell removal treatment

Dermis mechanical behaviour: influence of cell removal treatment

Biophysical characterization of ovine forestomach extracellular matrix biomaterials

Characterizing Morphology and Nonlinear Elastic Properties of Normal and Thermally Stressed Engineered Oral Mucosal Tissues Using Scanning Acoustic Microscopy

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