Noninvasive Investigation of Deep Vascular Pathologies of Exudative Macular Diseases by High-Penetration Optical Coherence Angiography

Hong, Young-Joo; Miura, Masahiro; Makita, Shuichi; Ju, Myeong Jin; Lee, Byeong Ha; Iwasaki, Takuya; Yasuno, Yoshiaki

doi:10.1167/iovs.12-11184

Cited by 37 publications

(33 citation statements)

References 33 publications

(38 reference statements)

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“…While the recently developed OCT-based angiography (OCT-A) [60][61][62][63] visualizes the vascular structure, it has no sensitivity to RPE abnormalities. In contrast, the multifunctional OCT presented here visualizes both RPE and pigmentation abnormalities through DOPU in addition to the vascular structure abnormalities through cmOCA.…”

Section: Clinical Utility Of Multifunctional Oct Imagingmentioning

confidence: 99%

Birefringence imaging of posterior eye by multi-functional Jones matrix optical coherence tomography

Sugiyama

Hong

Kasaragod

et al. 2015

Biomed. Opt. Express

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Abstract:A clinical grade prototype of posterior multifunctional Jones matrix optical coherence tomography (JM-OCT) is presented. This JM-OCT visualized depth-localized birefringence in addition to conventional cumulative phase retardation imaging through local Jones matrix analysis. In addition, it simultaneously provides a sensitivity enhanced scattering OCT, a quantitative polarization uniformity contrast, and OCT-based angiography. The probe beam is at 1-µm wavelength band. The measurement speed and the depth-resolution were 100,000 A-lines/s, and 6.6 µm in tissue, respectively. Normal and pathologic eyes are examined and several clinical features are revealed, which includes high birefringence in the choroid and lamina cribrosa, and birefringent layered structure of the sclera. The theoretical details of the depth-localized birefringence imaging and conventional phase retardation imaging are formulated. This formulation indicates that the birefringence imaging correctly measures a depth-localized single-trip phase retardation of a tissue, while the conventional phase retardation can provide correct single-trip phase retardation only for some specific types of samples.

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Section: Clinical Utility Of Multifunctional Oct Imagingmentioning

confidence: 99%

Birefringence imaging of posterior eye by multi-functional Jones matrix optical coherence tomography

Sugiyama

Hong

Kasaragod

et al. 2015

Biomed. Opt. Express

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“…13,14 This Doppler OCT was based on a swept-source technology, and operated at an axial scan speed of 100 000 A-scans/s, using a swept-source laser at a central wavelength of 1060 nm. The axial resolution for the tissue in this study was 6.4 mm.…”

Section: This Prospective Nonrandomized Study Wasmentioning

confidence: 99%

“…11 The clinical utility of Doppler OCT in evaluating the 3-dimensional vascular architecture of choroidal new vessels has already been reported. [11][12][13] It is therefore possible that Doppler OCT can facilitate a more comprehensive evaluation of retinal neovascularization in PDR. In this study, we present the clinical application of Doppler OCT for characterization of PDR, and describe the 3-dimensional vascular architecture at the site of neovascularization.…”

mentioning

confidence: 99%

Three-dimensional Vascular Imaging of Proliferative Diabetic Retinopathy by Doppler Optical Coherence Tomography

Miura

Hong

Yasuno

et al. 2015

American Journal of Ophthalmology

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“…OCTA has now been widely used in the imaging of cerebrovascular perfusion [6][7][8], retinal microcirculation [9,10], skin conditions [11,12] and tumor progression [13] etc. In ophthalmic imaging, OCTA has already been demonstrated useful to visualize and monitor CNVs [14][15][16], potentially providing additional critical information in clinical decision making. However it is noticed that in OCTA there is undesired projection effect from overlying blood vessels that leads to strong image artifacts appearing in the results of blood vessel networks within outer retinal space and choroid.…”

Section: Introductionmentioning

confidence: 99%

Minimizing projection artifacts for accurate presentation of choroidal neovascularization in OCT micro-angiography

Zhang

Wang

2015

Biomed. Opt. Express

162

150

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Current optical coherence tomography (OCT) based microangiography is prone to a projection (or tailing) effect due to the high scattering property of blood within overlying patent vessels, creating artifacts that interfere with the interpretation of retinal angiographic results. In this work, the projection effect in OCT micro-angiography is examined and its causality is explained by strong light scattering and photon propagation within blood. A simple practical approach is then introduced to minimize these artifacts presented in the outer retinal avascular space, especially useful for examining clinical cases with choroidal neovascularization (CNV). Demonstrated through in-vivo human posterior eye imaging of healthy and CNV subjects, the proposed method is shown effective to eliminate the projection artifacts in outer retinal space of OCT micro-angiography, resulting in better visualization of the pathological neovascularization when compared with the current common approaches. In addition, it is also shown that the proposed method is applicable to minimize the projection artifacts appearing in deep retinal layers.

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Noninvasive Investigation of Deep Vascular Pathologies of Exudative Macular Diseases by High-Penetration Optical Coherence Angiography

Abstract: HP-OCA revealed depth-resolved abnormal vasculatures in exudative macular diseases. The en face HP-OCA images showed high similarity with FA and ICGA images. These results suggest HP-OCA can be used for noninvasive and three-dimensional angiography in a clinical routine.

Cited by 37 publications

References 33 publications

Birefringence imaging of posterior eye by multi-functional Jones matrix optical coherence tomography

Birefringence imaging of posterior eye by multi-functional Jones matrix optical coherence tomography

Three-dimensional Vascular Imaging of Proliferative Diabetic Retinopathy by Doppler Optical Coherence Tomography

Minimizing projection artifacts for accurate presentation of choroidal neovascularization in OCT micro-angiography

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