Three-dimensional Vascular Imaging of Proliferative Diabetic Retinopathy by Doppler Optical Coherence Tomography

Miura, Masahiro; Hong, Young-Joo; Yasuno, Yoshiaki; Muramatsu, Daisuke; Iwasaki, Takuya; Gotô, Hiroshi

doi:10.1016/j.ajo.2014.12.002

Cited by 36 publications

(22 citation statements)

References 27 publications

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“…; Miura et al. ). Indeed, OCT angiography images clearly show, in the superficial plexus, the total capillary dropout and rare residual vessels with truncated capillaries, and, in the deep plexus, vertical anastomotic branches that join the superficial and deep plexuses in ischaemic diabetic maculopathy (Figs ).…”

Section: Discussionmentioning

confidence: 96%

Optical coherence tomography angiography versus fluorescein angiography in the diagnosis of ischaemic diabetic maculopathy

Cennamo

Romano

Nicoletti

et al. 2016

Acta Ophthalmologica

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ABSTRACT.Purpose: To evaluate the efficacy of optical coherence tomography (OCT) angiography versus fluorescein angiography (FA) in terms of retinal vessel imaging in ischaemic diabetic maculopathy defined according to the Early Treatment Diabetic Retinopathy Study (ETDRS) classification. Methods: Twenty patients (31 eyes) with ischaemic diabetic maculopathy and 17 control subjects (27 eyes) were enrolled in this prospective study. Patients and control subjects underwent complete ophthalmic examination, including bestcorrected visual acuity (BCVA), intraocular pressure, FA, Fourier domain optical coherence tomography (FD-OCT) and OCT angiography. Fluorescein angiograms and OCT angiography images were graded according to the foveal avascular zone (FAZ) of the ETDRS group. Ganglion cell complex (GCC) thickness was evaluated with FD-OCT. Results: Optical coherence tomography (OCT) angiography images closely correlated with FA in terms of FAZ parameters. The correlation was strongest with OCT angiography deep imaging. The average GCC thickness was smaller in patients than in controls. Neither GCC parameters nor FAZ was correlated to BCVA. Conclusions: Given the correlation between FA and OCT angiography in terms of FAZ parameters, the newer method can be considered a valid, reliable and easy-to-perform method with which to evaluate ischaemic diabetic maculopathy without contrast injection, and thus to visualize and quantify non-perfusion areas without risks of anaphylactic reactions.

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Section: Discussionmentioning

confidence: 96%

Optical coherence tomography angiography versus fluorescein angiography in the diagnosis of ischaemic diabetic maculopathy

Cennamo

Romano

Nicoletti

et al. 2016

Acta Ophthalmologica

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“…The resulting E is scaled by fitting the range [5,99.9] percentile of the average RGB value, (R + G + B)/3, to within the range of [0, 1]. As this is in the linear sRGB space, the gamma correction is applied to fit with the sRGB standard [56].…”

Section: Retinal Angiography With Degree Of Polarization Uniformitymentioning

confidence: 99%

Noise-immune complex correlation for optical coherence angiography based on standard and Jones matrix optical coherence tomography

Makita

Kurokawa

Hong

et al. 2016

Biomed. Opt. Express

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This paper describes a complex correlation mapping algorithm for optical coherence angiography (cmOCA). The proposed algorithm avoids the signal-to-noise ratio dependence and exhibits low noise in vasculature imaging. The complex correlation coefficient of the signals, rather than that of the measured data are estimated, and two-step averaging is introduced. Algorithms of motion artifact removal based on non perfusing tissue detection using correlation are developed. The algorithms are implemented with Jones-matrix OCT. Simultaneous imaging of pigmented tissue and vasculature is also achieved using degree of polarization uniformity imaging with cmOCA. An application of cmOCA to in vivo posterior human eyes is presented to demonstrate that high-contrast images of patients' eyes can be obtained.

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“…D‐OCT detects the phase shift of the backscattered light to provide velocity sensitivity. The clinical utility of D‐OCT has previously been reported with regard to detection of blood flow and tissue vibration . It is therefore possible for D‐OCT to facilitate detection of microscopic ciliary motion with more moderate axial resolutions.…”

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confidence: 99%

Measurement of ciliary beat frequency using Doppler optical coherence tomography

Lemieux

Chen

Jing

et al. 2015

Int Forum Allergy Rhinol

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1. Introduction Measuring ciliary beat frequency (CBF) is a technical challenge and difficult to perform in vivo. Doppler optical coherence tomography (D-OCT) is a mesoscopic non-contact imaging modality that provides high-resolution tomographic images and detects micromotion simultaneously in living tissues. Here we use D-OCT to measure CBF in ex vivo tissue as the first step toward translating this technology to clinical use. 2. Methods Fresh ex vivo samples of rabbit tracheal mucosa were imaged using both D-OCT and phase-contrast microscopy (n = 5). The D-OCT system was designed and built to specification in our lab (1310 nm swept source vertical-cavity surface-emitting laser (VCSEL), 6 μm axial resolution). The samples were placed in culture and incubated at 37°C. A fast Fourier transform was performed on the D-OCT signal recorded on the surface of the samples to gauge CBF. High-speed digital video of the epithelium recorded via phase-contrast microscopy was analyzed to confirm the CBF measurements. 3. Results The D-OCT system detected Doppler signal at the epithelial layer of ex vivo rabbit tracheal samples suggestive of ciliary motion. CBF was measured at 9.36 ± 1.22 Hz using D-OCT and 9.08 ± 0.48 Hz using phase-contrast microscopy. No significant differences were found between the two methods (p ≫ 0.05). 4. Conclusions D-OCT allows for the quantitative measurement of CBF without the need to resolve individual cilia. Furthermore, D-OCT technology can be incorporated into endoscopic platforms that allow clinicians to readily measure CBF in the office and provide a direct measurement of mucosal health.

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Three-dimensional Vascular Imaging of Proliferative Diabetic Retinopathy by Doppler Optical Coherence Tomography

Abstract: Doppler OCT is useful for the detection and evaluation of the 3-dimensional vascular structure of neovascularization, and can assist in the noninvasive assessment of proliferative diabetic retinopathy.

Cited by 36 publications

References 27 publications

Optical coherence tomography angiography versus fluorescein angiography in the diagnosis of ischaemic diabetic maculopathy

Optical coherence tomography angiography versus fluorescein angiography in the diagnosis of ischaemic diabetic maculopathy

Noise-immune complex correlation for optical coherence angiography based on standard and Jones matrix optical coherence tomography

Measurement of ciliary beat frequency using Doppler optical coherence tomography

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