Birefringence imaging of posterior eye by multi-functional Jones matrix optical coherence tomography

Sugiyama, Satoshi; Hong, Young-Joo; Kasaragod, Deepa; Makita, Shuichi; Uematsu, Sato; Ikuno, Yasushi; Miura, Masahiro; Yasuno, Yoshiaki

doi:10.1364/boe.6.004951

Cited by 57 publications

(76 citation statements)

References 60 publications

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“…The dermatological JM-OCT system was built from the passive-polarization-delay-based PS-OCT [22,27,28,43,44]. The schematic of our JM-OCT is shown in Fig.…”

Section: Jones Matrix Oct Systemmentioning

confidence: 99%

“…The PPD module used in this system has a configuration that is similar to the one in [22,27], but all the optical components are miniaturized and encased in a small box (91 mm × 50 mm foot print and 30 mm height). This compact PPD module (DE-G043-13, Optohub Co. Ltd., Saitama, Japan) was collaboratively developed with Optohub Co. Ltd. and is commercially available.…”

Section: Jones Matrix Oct Systemmentioning

confidence: 99%

“…Different delays are applied to the two polarizations before recombination. This mutual delay results in the depth-multiplexing of the two incident polarizations in the resulting OCT image [22,27]. The output power of the PPD is maximized by a fiber polarization controller just before the PPD module (PC1), i.e., just before the polarizer.…”

Section: Jones Matrix Oct Systemmentioning

confidence: 99%

“…Currently, most dermatological PS-OCT measures phase retardation to detect the polarization property of the skin. However, it was recently argued that the phase retardation measurement is not accurate for biological tissues with non-uniform optic axis orientation along its depth, which includes skin [22]. Therefore, a depth-localized birefringence measurement is required for more accurate dermatological investigation.…”

Section: Introductionmentioning

confidence: 99%

“…The JM-OCT simultaneously provides depth-resolved birefringence (local phase retardation) tomography [25], degree-ofpolarization-uniformity (DOPU) [40,41], complex-correlation based OCT-A [42], and the scattering intensity OCT. The system is based on a design that is similar to our previous passive-polarization-delay based posterior-eye JM-OCT [22,27], but is specially redesigned for dermatological investigation. The performance of the system is demonstrated by measuring different skin tissues in vivo.…”

Section: Introductionmentioning

confidence: 99%

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Three-dimensional multi-contrast imaging of in vivo human skin by Jones matrix optical coherence tomography

Makita

Hong

et al. 2017

Biomed. Opt. Express

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A custom made dermatological Jones matrix optical coherence tomography (JM-OCT) is presented. It uses a passive-polarization-delay component based swept-source JM-OCT configuration, but is specially designed for in vivo human skin measurement. The center wavelength of its probe beam is 1310 nm and the A-line rate is 49.6 kHz. The JM-OCT is capable of simultaneously providing birefringence (local retardation) tomography, degree-ofpolarization-uniformity tomography, complex-correlation-based optical coherence angiography, and conventional scattering OCT. To evaluate the performance of this JM-OCT, we measured in vivo human skin at several locations. Using the four kinds of OCT contrasts, the morphological characteristics and optical properties of different skin types were visualized.

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“…The dermatological JM-OCT system was built from the passive-polarization-delay-based PS-OCT [22,27,28,43,44]. The schematic of our JM-OCT is shown in Fig.…”

Section: Jones Matrix Oct Systemmentioning

confidence: 99%

Section: Jones Matrix Oct Systemmentioning

confidence: 99%

Section: Jones Matrix Oct Systemmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Three-dimensional multi-contrast imaging of in vivo human skin by Jones matrix optical coherence tomography

Makita

Hong

et al. 2017

Biomed. Opt. Express

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Polarization-Sensitive OCT Imaging of Scleral Abnormalities in Eyes With High Myopia and Dome-Shaped Macula

Ohno-Matsui,

Igarashi-Yokoi,

Azuma

et al. 2024

JAMA Ophthalmol

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ImportanceThe relevance of visualizing scleral fiber orientation may offer insights into the pathogenesis of pathologic myopia, including dome-shaped maculopathy (DSM).ObjectiveTo investigate the orientation and density of scleral collagen fibers in highly myopic eyes with and without DSM by polarization-sensitive optical coherence tomography (PS-OCT).Design, Setting, and ParticipantsThis case series included patients with highly myopic eyes (defined as a refractive error ≥6 diopters or an axial length ≥26.5 mm) with and without a DSM examined at a single site in May and June 2019. Analysis was performed from September 2019 to October 2023.ExposuresThe PS-OCT was used to study the birefringence and optic axis of the scleral collagen fibers.Main Outcomes and MeasuresThe orientation and optic axis of scleral fibers in inner and outer layers of highly myopic eyes were assessed, and the results were compared between eyes with and without a DSM.ResultsA total of 72 patients (51 [70.8%] female; mean [SD] age, 61.5 [12.8] years) were included, and 89 highly myopic eyes were examined (mean [SD] axial length, 30.4 [1.7] mm); 52 (58.4%) did not have a DSM and 37 (41.6%) had a DSM (10 bidirectional [27.0%] and 27 horizontal [73.0%]). Among the 52 eyes without DSM, the 13 eyes with simple high myopia had primarily inner sclera visible, displaying radially oriented fibers in optic axis images. In contrast, the entire thickness of the sclera was visible in 39 eyes with pathologic myopia. In these eyes, the optic axis images showed vertically oriented fibers within the outer sclera. Eyes presenting with both horizontal and bidirectional DSMs had clusters of fibers with low birefringence at the site of the DSM. In the optic axis images, horizontally or obliquely oriented scleral fibers were aggregated in the inner layer at the DSM. The vertical fibers located posterior to the inner fiber aggregation were not thickened and appeared thin compared with the surrounding areas.Conclusions and RelevanceThis study using PS-OCT revealed inner scleral fiber aggregation without outer scleral thickening at the site of the DSM in highly myopic eyes. Given the common occurrence of scleral pathologies, such as DSM, and staphylomas in eyes with pathologic myopia, recognizing these fiber patterns could be important. These insights may be relevant to developing targeted therapies to address scleral abnormalities early and, thus, mitigate potential damage to the overlying neural tissue.

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Functional optical coherence tomography of neurovascular coupling interactions in the retina

Son

Alam

Toslak

et al. 2018

Journal of Biophotonics

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Quantitative evaluation of retinal neurovascular coupling is essential for a better understanding of visual function and early detection of eye diseases. However, there is no established method to monitor coherent interactions between stimulus-evoked neural activity and hemodynamic responses at high resolution. Here, we report a multimodal functional optical coherence tomography (OCT) imaging methodology to enable concurrent intrinsic optical signal (IOS) imaging of stimulus-evoked neural activity and hemodynamic responses at capillary resolution. OCT angiography guided IOS analysis was used to separate neural-IOS and hemodynamic-IOS changes in the same retinal image sequence. Frequency flicker stimuli evoked neural-IOS changes in the outer retina; that is, photoreceptor layer, first and then in the inner retina, including outer plexus layer (OPL), inner plexiform layer (IPL), and ganglion cell layer (GCL), which were followed by hemodynamic-IOS changes primarily in the inner retina; that is, OPL, IPL, and GCL. Different time courses and signal magnitudes of hemodynamic-IOS responses were observed in blood vessels with various diameters.

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Birefringence imaging of posterior eye by multi-functional Jones matrix optical coherence tomography

Cited by 57 publications

References 60 publications

Three-dimensional multi-contrast imaging of in vivo human skin by Jones matrix optical coherence tomography

Three-dimensional multi-contrast imaging of in vivo human skin by Jones matrix optical coherence tomography

Polarization-Sensitive OCT Imaging of Scleral Abnormalities in Eyes With High Myopia and Dome-Shaped Macula

Functional optical coherence tomography of neurovascular coupling interactions in the retina

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