2017
DOI: 10.1364/boe.8.001290
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Three-dimensional multi-contrast imaging of in vivo human skin by Jones matrix optical coherence tomography

Abstract: A custom made dermatological Jones matrix optical coherence tomography (JM-OCT) is presented. It uses a passive-polarization-delay component based swept-source JM-OCT configuration, but is specially designed for in vivo human skin measurement. The center wavelength of its probe beam is 1310 nm and the A-line rate is 49.6 kHz. The JM-OCT is capable of simultaneously providing birefringence (local retardation) tomography, degree-ofpolarization-uniformity tomography, complex-correlation-based optical coherence an… Show more

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Cited by 80 publications
(69 citation statements)
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“…Compared to cumulative retardation measurements, local measurements of birefringent properties provide a more intuitive approach to tissue architecture and composition. For instance, in collagenous tissue such as skin, local birefringence can be used for the depth-resolved assessment of the collagen content [77,78]. Different applications of birefringence imaging of collagen in healthy and diseased tissues will be discussed in Section 3.…”
Section: Ps-oct Based On Multiple Input Statesmentioning
confidence: 99%
“…Compared to cumulative retardation measurements, local measurements of birefringent properties provide a more intuitive approach to tissue architecture and composition. For instance, in collagenous tissue such as skin, local birefringence can be used for the depth-resolved assessment of the collagen content [77,78]. Different applications of birefringence imaging of collagen in healthy and diseased tissues will be discussed in Section 3.…”
Section: Ps-oct Based On Multiple Input Statesmentioning
confidence: 99%
“…This JM-OCT multiplexed two incident polarization states using passive polarization delay, and two output polarizations were measured using a polarization diversity detector [9,10,12,18,23,24]. Thus, it measured a set of four OCT images by a single scan.…”
Section: Jm-oct System and Measurement Protocolmentioning
confidence: 99%
“…Polarization sensitive OCT (PS-OCT) provides not only structural information but also the polarization properties of the sample [4,5]. Among the polarization properties, local birefringence (BR) is considered to provide collagen contrast [6][7][8][9][10][11][12][13]. The degree of polarization uniformity (DOPU) is another polarization property [14][15][16][17].…”
Section: Introductionmentioning
confidence: 99%
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“…Images of structure, birefringence, collagen orientation change, and blood vessels are obtained and analyzed. Although a few of multifunctional PS‐OCT studies have been reported to examine birefringence and blood vessels in human skin and eyes , no reports have demonstrated assessments in tissue birefringence and microcirculatory response to wound in healing.…”
Section: Introductionmentioning
confidence: 99%