Noninvasive follicular thyroid neoplasm with papillary-like nuclear features: A distinct clinicopathologic entity

Fonseca, Daphne; Bhuyan, Srutimala; Murthy, Sudha; Rao, Vishal; Rao, Chandrasekhara; Raju, Kalyani; Challa, Sundaram

doi:10.4103/ijpm.ijpm_185_17

Cited by 8 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The current report demonstrated a classic case of NIFTP affecting a young female child, agreeing with previous reports that there are more cases in women than men ( Table 1 ). Although not common, multifocality has been reported previously for NIFTP in adults 15 and in children 9 . The size of NIFTP lesion is usually small, rarely exceeding 2 cm in diameter ( Table 1 ).…”

Section: Discussionmentioning

confidence: 73%

Case Report: Multifocal non-invasive follicular thyroid neoplasm with papillary-like nuclear features presenting in a female child

2020

View full text Add to dashboard Cite

Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was introduced as a separate entity by the World Health Organization in 2017 with strict inclusion and exclusion criteria. Most NIFTP cases have been reported in adults and few cases have been diagnosed in children. Here, we present a classic case of NIFTP affecting a 10-year old female child. We also review previous reports of NIFTP in children regarding size, focality, nodal metastasis, recurrence, type of operation and follow-up data. The present report adds a new case of NIFTP in the paediatric age group characterized by multifocality, absence of nodal invasion and indolent course until last follow-up, recommending less aggressive management.

show abstract

Section: Discussionmentioning

confidence: 73%

Case Report: Multifocal non-invasive follicular thyroid neoplasm with papillary-like nuclear features presenting in a female child

2020

View full text Add to dashboard Cite

show abstract

“…An Indian study published recently found an incidence of 9.4% (33 cases of NIFTP in 349 cases of PTC) retrospectively. 11 Bychkov et al on the other hand presented data from East Asia, recorded only 1.5% (range 0-4.7%) which is approximately 10 times less compared to western series in which NIFTP was reported as 16-23% of all PTC in North America and European populations. 12,13 Hypothetically this striking difference could be due to various reasons including geographic and ethnic differences among Asian populations, the method of nodule detection, as in our country it is usually detected on palpation whereas in USA and many other countries nodules detected as an incidental finding on imaging are also examined.…”

Section: Discussionmentioning

confidence: 89%

Non Invasive Follicular Thyroid Neoplasm with Papillary like nuclear features (NIFTP): A time for change in Pakistan

et al. 2019

View full text Add to dashboard Cite

Objective: To determine the cases of Noninvasive Follicular thyroid neoplasm with papillary like nuclear features (NIFTP) in Pakistani population retrospectively. Another objective was to determine their clinical and radiological outcomes with respect to local and systemic disease recurrence, reconfirming the benign course of this new nomenclature in Thyroid tumors by WHO in our population would encourage adopting the new conservative treatment approach in such patients. Methods: This is a retrospective cohort study conducted at a tertiary care center in Karachi, Pakistan from 2007-2016. All follicular Variant papillary thyroid cancer (FVPTC) reported from a single institute had their histopathology slides reexamined for diagnosing NIFTP as per the new WHO criteria. These cases were then followed retrospectively from their diagnosis onset through their medical and electronic health record for any local or systemic disease recurrence. Results: There were 199 cases of Papillary Thyroid cancer (PTC) which included 22 cases of FVPTC. Eleven cases fulfilled NIFTP criteria with tumor size ranging from 1.1cm to ≥ 5.5cm. All patients in the NIFTP group underwent total thyroidectomy. Nine patients (81.81%) received RAI131 therapy. Four (45%) patients had a median follow up of three to four years. There was no disease recurrence seen on both ultrasound and RAI scans of patients in the NIFTP group. Seven patients (87.5%) had normal surveillance thyroglobulin levels except one whereas three patients were lost to follow up. There was no disease recurrence seen both radiologically and biochemically in the NIFTP group. Conclusion: Our study favors the low risk nature of NIFTP with no disease recurrence in the cases studied and encourages de-escalation of treatment. doi: https://doi.org/10.12669/pjms.36.2.1123 How to cite this:Jabeen S, Fatima S, Sheikh A, Islam N. Non Invasive Follicular Thyroid Neoplasm with Papillary like nuclear features (NIFTP), A time for change in Pakistan. Pak J Med Sci. 2020;36(2):---------. doi: https://doi.org/10.12669/pjms.36.2.1123 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

show abstract

“…The introduction of NIFTP in 2016 has implications on the management of thyroid nodules and influenced the ROM in each Bethesda category, especially in categories III and IV. 19,20 However, the prevalence of NIFTP and the impact of NIFTP reclassification on the 22 Reasons for the discrepancy between Asian and Western studies may be multifactorial, including variation in the incidence of FVPTCs between continents, 23 racial and ethnic predispositions to PTC, 24 and varying threshold of diagnosing nuclear features of PTC.…”

Section: Discussionmentioning

confidence: 99%

Noninvasive follicular thyroid neoplasm with papillary-like nuclear features and the risk of malignancy in thyroid cytology: Data from Singapore

Lee

Bundele

Tan

et al. 2021

Ann Acad Med Singap

View full text Add to dashboard Cite

Introduction: The impact of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) on the risk of malignancy (ROM) in fine-needle aspiration cytology (FNAC) per The Bethesda System for Reporting Thyroid Cytopathology has not been well reported in Singapore. Methods: We retrospectively identified 821 thyroid nodules with preoperative FNAC from 788 patients out of 1,279 consecutive thyroidectomies performed between January 2010 and August 2016 in a tertiary general hospital in Singapore. Possible cases of NIFTP were reviewed for reclassification and the impact of NIFTP on ROM was analysed. Results: The incidence of NIFTP was 1.2% (10 out of 821). If NIFTP is considered benign, ROM in Bethesda I through VI were 8.6%, 3.5%, 26.3%, 20.0%, 87.7%, 97.0% versus 8.6%, 4.2%, 28.1%, 26.7%, 89.2% and 100% if NIFTP is considered malignant. Eight patients with NIFTP had follow-up of 15 to 110 months. One had possible rib metastasis as evidenced by I131 uptake but remained free of structural or biochemical disease during a follow-up period of 110 months. None had lymph node metastasis at presentation, nor locoregional or distant recurrence. Conclusion: Classifying NIFTP as benign decreased ROM in Bethesda II through VI, but the benignity of NIFTP requires more prospective studies to ascertain. The impact of NIFTP on ROM in our institution also appears to be lower than that reported in the Western studies Keywords: Bethesda, cytology, NIFTP, risk of malignancy, TBSRTC, thyroid nodule

show abstract

Noninvasive follicular thyroid neoplasm with papillary-like nuclear features: A distinct clinicopathologic entity

Abstract: Thyroid carcinomas currently diagnosed as FVPTC should be evaluated for criteria of NIFTP to avoid overtreatment as they have an indolent behavior.

Cited by 8 publications

References 8 publications

Case Report: Multifocal non-invasive follicular thyroid neoplasm with papillary-like nuclear features presenting in a female child

Case Report: Multifocal non-invasive follicular thyroid neoplasm with papillary-like nuclear features presenting in a female child

Non Invasive Follicular Thyroid Neoplasm with Papillary like nuclear features (NIFTP): A time for change in Pakistan

Noninvasive follicular thyroid neoplasm with papillary-like nuclear features and the risk of malignancy in thyroid cytology: Data from Singapore

Contact Info

Product

Resources

About