Noninvasive encapsulated follicular variant of papillary thyroid carcinoma: Should it also be reclassified in children?

Mariani, R; Kadakia, Rachel; Arva, Nicoleta C.

doi:10.1002/pbc.26966

Cited by 15 publications

(4 citation statements)

References 26 publications

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“…All previously reported cases in the English literature (n = 12) were included for comparison (total n = 15). 18–21 Based on available data of the 15 cases, majority were female (69%) and aged from 9 to17 years at the time of diagnosis. Tumor size ranged from 0.4 to 3.1 cm, with an average of 1.8 cm.…”

Section: Resultsmentioning

confidence: 99%

“…12,13,16,17 However, studies describing the tumor characteristics and behavior of NIFTP in the pediatric population are scant, with only a total of 12 cases reported in the literature. 18–21 It is not clear if the experience of NIFTP derived from studies predominantly in adult patients can be equally applied to children, given the clinicopathologic differences between PTC in adult and pediatric patients.…”

Section: Introductionmentioning

confidence: 99%

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Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features in Children: An Institutional Experience and Literature Review

et al. 2019

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Background Papillary thyroid carcinoma (PTC) in children has a distinctive set of clinicopathologic features and molecular signature compared to their adult counterparts. The recent recommendation to reclassify encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC) without invasion as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is based on evidence derived almost exclusively from studies in adults. Clinicopathologic studies restricted to pediatric NIFTP are limited. Methods We retrospectively analyzed all pediatric PTC and NIFTP diagnosed and treated in our institution from 1999 to 2016 (n = 31). Results Using recently published consensus diagnostic criteria, we identified 3 NIFTP and 2 infiltrative follicular variants of papillary thyroid carcinoma (FVPTC) among 31 cases. Two of the NIFTP cases were initially diagnosed as EFVPTC. All 3 patients with NIFTP had unifocal tumors of lower American Joint Committee on Cancer (AJCC) classification (T2 or lower) and were free of lymph node or distant metastasis. Total (n = 1) or completion (n = 2) thyroidectomy was performed in all cases, and only 1 NIFTP patient received subsequent radioablative therapy. No residual or recurrent disease has been observed during follow-up (15–138 months) in patients with NIFTP. Conclusions Our experience with NIFTP in children is similar to outcomes reported in adult studies, suggesting that pediatric NIFTP behave indolently as evidenced by the absence of local recurrence in our cohort.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features in Children: An Institutional Experience and Literature Review

et al. 2019

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“…The current report demonstrated a classic case of NIFTP affecting a young female child, agreeing with previous reports that there are more cases in women than men ( Table 1 ). Although not common, multifocality has been reported previously for NIFTP in adults 15 and in children 9 . The size of NIFTP lesion is usually small, rarely exceeding 2 cm in diameter ( Table 1 ).…”

Section: Discussionmentioning

confidence: 72%

“…NIFTP cytology was commonly interpreted as follicular lesion of undetermined significance in 30% (categories III and IV according to Bethesda system), follicular neoplasm in 21%, suspicious for malignancy in 24%, malignant in 8%, bnign in 10% and non-diagnostic in 3% 11 , 12 . Although the above findings would suggest lobectomy, our patient was submitted for total thyroidectomy and as has been done in previously reported cases 6 , 7 , 9 , 10 .…”

Section: Discussionmentioning

confidence: 72%

Case Report: Multifocal non-invasive follicular thyroid neoplasm with papillary-like nuclear features presenting in a female child

2020

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Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was introduced as a separate entity by the World Health Organization in 2017 with strict inclusion and exclusion criteria. Most NIFTP cases have been reported in adults and few cases have been diagnosed in children. Here, we present a classic case of NIFTP affecting a 10-year old female child. We also review previous reports of NIFTP in children regarding size, focality, nodal metastasis, recurrence, type of operation and follow-up data. The present report adds a new case of NIFTP in the paediatric age group characterized by multifocality, absence of nodal invasion and indolent course until last follow-up, recommending less aggressive management.

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Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) in children and adolescents

Rosário¹,

Mourão²

2018

Endocrine

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Noninvasive encapsulated follicular variant of papillary thyroid carcinoma: Should it also be reclassified in children?

Abstract: In children, noniEFVPTC/NIFTP has indolent behavior, warranting consideration of less aggressive management, similar to adults.

Cited by 15 publications

References 26 publications

Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features in Children: An Institutional Experience and Literature Review

Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features in Children: An Institutional Experience and Literature Review

Case Report: Multifocal non-invasive follicular thyroid neoplasm with papillary-like nuclear features presenting in a female child

Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) in children and adolescents

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