Noninvasive and High-Resolution Optical Monitoring of Healing of Diabetic Dermal Excisional Wounds Implanted with Biodegradable <i>In Situ</i> Gelable Hydrogels

Yuan, Zhijun; Zakhaleva, Julia; Ren, Hugang; Liu, Jingxuan; Chen, Weiliam; Pan, Yingtian

doi:10.1089/ten.tec.2009.0152

Cited by 24 publications

(21 citation statements)

References 23 publications

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“…Attempts have been made to quantify such measurements, such as with the use of the Vancouver scar scale and the Manchester scar proforma, but these too suffer from significant subjective drawbacks (9,10). Currently, biopsies provide the best objective assessment of wound recovery, but this technique causes further tissue destruction and increases the risk of infection (11).…”

Section: Introductionmentioning

confidence: 99%

Optical coherence tomography angiography monitors human cutaneous wound healing over time

Deegan¹,

Men²,

Li³

et al. 2018

Quant. Imaging Med. Surg.

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Background: In vivo imaging of the complex cascade of events known to be pivotal elements in the healing of cutaneous wounds is a difficult but essential task. Current techniques are highly invasive, or lack the level of vascular and structural detail required for accurate evaluation, monitoring and treatment. We aimed to use an advanced optical coherence tomography (OCT)-based angiography (OCTA) technique for the noninvasive, high resolution imaging of cutaneous wound healing.Methods: We used a clinical prototype OCTA to image, identify and track key vascular and structural adaptations known to occur throughout the healing process. Specific vascular parameters, such as diameter and density, were measured to aid our interpretations under a spatiotemporal framework.Results: We identified multiple distinct, yet overlapping stages, hemostasis, inflammation, proliferation, and remodeling, and demonstrated the detailed vascularization and anatomical attributes underlying the multifactorial processes of dermatologic wound healing.Conclusions: OCTA provides an opportunity to both qualitatively and quantitatively assess the vascular response to acute cutaneous damage and in the future, may help to ascertain wound severity and possible healing outcomes; thus, enabling more effective treatment options.

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Section: Introductionmentioning

confidence: 99%

Optical coherence tomography angiography monitors human cutaneous wound healing over time

Deegan¹,

Men²,

Li³

et al. 2018

Quant. Imaging Med. Surg.

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“…6 Thus, OCT has been used to characterize hydrogel implants in different settings. 7,8,9,10,11 Further, ultrahigh resolution and polarization sensitive OCT techniques have been developed. Ultrahigh resolution systems utilize lasers with large spectral bandwidths, such as Ti:sapphire femtosecond lasers, resulting in a coherence length or axial resolution <4 mm in air.…”

Section: Optical Coherence Tomographymentioning

confidence: 99%

“…Four examples, which span different imaging modalities and tissue types, include the in vivo LDI and ex vivo microCT imaging of angiogenic blood vessels, 47 tissue repair, 39 the in vivo OCT imaging of cartilage repair, 9 and the in vivo OCT imaging of skin wound healing. 10,11 Vessel ingrowth into poly(ethylene glycol) (PEG) hydrogels delivering VEGF was characterized by several imaging techniques in vivo. 47 LDI and microCT images are shown in Fig.…”

Section: Evaluation Of Tissue Morphologymentioning

confidence: 99%

Imaging hydrogel implants in situ

Patterson

2011

Biomedical Hydrogels

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“…Scattering is not a major factor in the signal degeneration. This method has been shown to be useful to detect breast cancer (Ermilov SA et al, 2009), to visualize vasculature in mouse brain by adding golden nano-spheres to improve optical contrast (Lu W et al, 2010), to evaluate tissue growth and regeneration (Yuan Z et al, 2010), and 3-D visualization blood vessels (Zhang EZ et al, 2009). In fact different variations of this technique have been developed for specific clinical applications.…”

Section: Biological Imaging Requirementsmentioning

confidence: 99%