Nongenomic and genomic effects of 1α,25(OH)2 vitamin D3 in rat testis

Zanatta, Leïla; Zamoner, Ariane; Zanatta, Ana Paula; Bouraïma-Lelong, Hélène; Delalande, Christelle; Bois, Camille; Carreau, Serge; Silva, Fátima Regina Mena Barreto

doi:10.1016/j.lfs.2011.04.008

Cited by 47 publications

(46 citation statements)

References 82 publications

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“…The observed binding affinity is in line with a previous study showing that K d for VDR in the rat testis was 50 pM (Gensure et al 1991). Later in vitro studies also showed rapid effects when using similar 1,25(OH) 2 D 3 concentrations (50 pM-1 nM) in both immature rodent Sertoli cells and ejaculated human spermatozoa (Blomberg Jensen et al 2011, Menegaz et al 2011, Zanatta et al 2011c. Spermatozoa are highly compartmentalized cells and each compartment has different functions reflected by the spatial expression of several ion channels, transporters, etc., that are confined to a particular compartment (Publicover et al 2007).…”

Section: Vitamin D and Male Reproductionsupporting

confidence: 89%

“…Immature Sertoli cells express VDR, aromatase, and AMH, while mature Sertoli cells do not express any of these proteins. The proposed actions of VD on immature Sertoli cells have recently been reviewed and will not be discussed further here, but it is likely that VD may be a regulator of AMH and GGT in immature Sertoli cells (Zanatta et al 2011c). The findings described earlier indicate that most of the VD-mediated effects in the testis and male reproductive tract are mediated through estrogen synthesis or aberrant expression of ER.…”

Section: Regulation Of Testicular Vd Metabolism and Putative Downstrementioning

confidence: 99%

“…VDR is expressed in both nucleus and cytoplasm of primary cultures of immature Sertoli cells and in the immature mice Sertoli cell line TM4, and 1,25(OH) 2 D 3 mediates fast nongenomic effects in both cell lines (Akerstrom & Walters 1992, Majumdar et al 1994, Menegaz et al 2010, 2011, Rosso et al 2011, Zanatta et al 2011a, 2011b. VDR is also expressed in spermatocytes and spermatids of both rodents and humans (Blomberg Jensen et al 2010a, 2010b, Zanatta et al 2011c, but Sertoli cells are still considered to be the main VD target in the adult testis (Zanatta et al 2011c). This assumption may not be entirely correct as testicular VDR expression increases during puberty and the observed temporal correlation of increased VDR levels with testicular maturation suggests a better correlation to testicular function and spermatogenesis than to growth of the organ in vivo.…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D metabolism, sex hormones, and male reproductive function

Jensen¹

2012

Reproduction

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The spectrum of vitamin D (VD)-mediated effects has expanded in recent years, and VD is now recognized as a versatile signaling molecule rather than being solely a regulator of bone health and calcium homeostasis. One of the recently identified target areas of VD is male reproductive function. The VD receptor (VDR) and the VD metabolizing enzyme expression studies documented the presence of this system in the testes, mature spermatozoa, and ejaculatory tract, suggesting that both systemic and local VD metabolism may influence male reproductive function. However, it is still debated which cell is the main VD target in the testis and to what extent VD is important for sex hormone production and function of spermatozoa. This review summarizes descriptive studies on testicular VD metabolism and spatial distribution of VDR and the VD metabolizing enzymes in the mammalian testes and discusses mechanistic and association studies conducted in animals and humans. The reviewed evidence suggests some effects of VD on estrogen and testosterone biosynthesis and implicates involvement of both systemic and local VD metabolism in the regulation of male fertility potential.

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Section: Vitamin D and Male Reproductionsupporting

confidence: 89%

Section: Regulation Of Testicular Vd Metabolism and Putative Downstrementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Vitamin D metabolism, sex hormones, and male reproductive function

Jensen¹

2012

Reproduction

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“…Recently, it has been shown that vitamin D treatment upregulates certain testis-specific genes in mouse testis (38) (41).…”

Section: Malesmentioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: Vitamin D and fertility: a systematic review

Lerchbaum

Obermayer-Pietsch

2012

European Journal of Endocrinology

337

252

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Background: Vitamin D has been well-known for its function in maintaining calcium and phosphorus homeostasis and promoting bone mineralization. There is some evidence that in addition to sex steroid hormones, the classic regulators of human reproduction, vitamin D also modulates reproductive processes in women and men. Aim: The aim of this review was to assess the studies that evaluated the relationship between vitamin D and fertility in women and men as well as in animals. Methods: We performed a systematic literature search in Pubmed for relevant English language publications published until October 2011. Results and discussion: The vitamin D receptor (VDR) and vitamin D metabolizing enzymes are found in reproductive tissues of women and men. Vdr knockout mice have significant gonadal insufficiency, decreased sperm count and motility, and histological abnormalities of testis, ovary and uterus. Moreover, we present evidence that vitamin D is involved in female reproduction including IVF outcome (clinical pregnancy rates) and polycystic ovary syndrome (PCOS). In PCOS women, low 25-hydroxyvitamin D (25(OH)D) levels are associated with obesity, metabolic, and endocrine disturbances and vitamin D supplementation might improve menstrual frequency and metabolic disturbances in those women. Moreover, vitamin D might influence steroidogenesis of sex hormones (estradiol and progesterone) in healthy women and high 25(OH)D levels might be associated with endometriosis. In men, vitamin D is positively associated with semen quality and androgen status. Moreover, vitamin D treatment might increase testosterone levels. Testiculopathic men show low CYP21R expression, low 25(OH)D levels, and osteoporosis despite normal testosterone levels.

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“…A representative protein is indicated for each pattern. also shown non-genomic rapid effects of vitamin D on Sertoli cell membranes [321], which may help to answer some questions that have interfered with our ability to understand the role this vitamin plays in spermatogenesis.…”

Section: Mta1mentioning

confidence: 96%