Nondigestible Oligosaccharides Increase Calcium Absorption and Suppress Bone Resorption in Ovariectomized Rats

Abstract

Nondigestible oligosaccharides (NDO) including inulin and fructooligosaccharides (FOS) have been reported to stimulate calcium absorption. Here we report the effect of a mixture of inulin and FOS (Raftilose Synergy 1, Orafti) on calcium and bone metabolism in ovariectomized (OVX) rats. OVX rats (6 mo old) were fed a semipurified diet for 3 mo in our animal care laboratory for stabilization after ovariectomy. They were then divided into two groups (n = 13/group) and fed either a control or a NDO-supplemented diet (55 g/kg) for 21 d. Catheters were placed in their jugular veins. After 2 d, a tracer ((45)Ca) was administered by gavage or i.v. and blood was sampled for up to 300 min. Urine and fecal samples were collected for 4 d after (45)Ca administration. Femurs were measured for bone mineral density (BMD), breaking strength, and total calcium. Calcium absorption, femoral calcium content, BMD, and bone balance (V(bal)) were significantly increased (P < 0.05) by NDO, whereas the bone resorption rate relative to the bone formation rate was significantly depressed by NDO. We conclude that feeding NDO at 5.5 g/100 g for 21 d has a positive effect on calcium absorption and retention in ovariectomized rats.

Dietas com mananoligossacarídeo e níveis reduzidos de cálcio para codornas japonesas

“…As aves que receberam os menores níveis de cálcio aumentaram seu consumo de ração na tentativa de aumentar a ingestão do mineral para atender suas exigências. Quando o mananoligossacarídeo foi adicionado à ração, o consumo se igualou ao observado nas aves ingerindo a dieta controle, provavelmente devido ao mecanismo de aumento de solubilidade do cálcio e hipertrofia das celulas intestinais como citado anteriormente (Juskiewicz et al, 2004;Suzuki & Hara, 2004;Zafar et al, 2004). Esses dois efeitos podem ter permitido que adequados níveis de cálcio circulantes fossem atingidos na ave, reduzindo ou anulando os efeitos do consumo de dietas deficientes em cálcio.…”

“…Além disso, os AGCC causam hipertrofia das células da mucosa aumentando a superfície de absorção do intestino (Kruger et al, 2003;Zafar et al, 2004).…”

Breadmaking performance and technological characteristic of gluten-free bread with inulin supplemented with calcium salts

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Improvement of Bone-Sparing Effect of Soy Isoflavones by Pre- and Probiotics in Postmenopausal women

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