Nondestructive imaging of human cartilage glycosaminoglycan concentration by MRI

Bashir, Adil; Gray, Martha L.; Hartke, James R.; Burstein, Deborah

doi:10.1002/(sici)1522-2594(199905)41:5<857::aid-mrm1>3.0.co;2-e

Cited by 533 publications

(224 citation statements)

References 23 publications

Supporting

Mentioning

211

Contrasting

Order By: Relevance

“…Some techniques, while appropriate for basic science research, are less suitable for clinical in vivo applications. Other methods, such as dGEMRIC and sodium MRI [6,7,40,42], which have been demonstrated for cartilage imaging, may not be readily applied to the disc due to the restricted diffusion of the contrast agent necessary for the technique. Potential advantages of T 1q MRI as a biomarker over other techniques include the ability to provide quantitative spatial measurements of disc substructures on a continuous scale, the ability to detect early, subtle changes of disc degeneration, and ease of implementation on 1.5 T clinical MR scanners without the need for significant hardware modifications.…”

Section: Discussionmentioning

confidence: 99%

In vivo quantification of human lumbar disc degeneration using T1ρ-weighted magnetic resonance imaging

et al. 2006

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

In vivo quantification of human lumbar disc degeneration using T1ρ-weighted magnetic resonance imaging

et al. 2006

View full text Add to dashboard Cite

“…Thus, detection of grade 1 lesions, using even the current MRI sequences, should warn of potential cartilage loss, and close attention should be directed to the affected articular cartilage on the followup studies. It is hoped that further development of highresolution MRI sequences will elucidate the nature of these lesions, and that sodium MRI or gadoliniumenhanced MRI may characterize the biochemical changes (20). Recent work by Mosher et al, using a 3.0T magnet, demonstrated a significant increase in T2 relaxation of the transitional zone of patellar articular cartilage in symptomatic patients when compared with asymptomatic controls (21).…”

Section: Discussionmentioning

confidence: 99%

Risk factors for progressive cartilage loss in the knee

Biswal¹,

Hastie²,

Andriacchi³

et al. 2002

Arthritis & Rheumatism

206

View full text Add to dashboard Cite

Objective. To evaluate the rate of progression of cartilage loss in the knee joint using magnetic resonance imaging (MRI) and to evaluate potential risk factors for more rapid cartilage loss.Methods. We evaluated baseline and followup MRIs of the knees in 43 patients (minimum time interval of 1 year, mean 1.8 years, range 52-285 weeks). Cartilage loss was graded in the anterior, central, and posterior regions of the medial and lateral knee compartments. Knee joints were also evaluated for other pathology. Data were analyzed using analysis of variance models.Results. Patients who had sustained meniscal tears showed a higher average rate of progression of cartilage loss (22%) than that seen in those who had intact menisci (14.9%) (P < 0.018). Anterior cruciate ligament (ACL) tears had a borderline significant influence (P < 0.06) on the progression of cartilage pathology. Lesions located in the central region of the medial compartment were more likely to progress to more advanced cartilage pathology (progression rate 28%; P < 0.003) than lesions in the anterior (19%; P < 0.564) and posterior (17%; P < 0.957) regions or lesions located in the lateral compartment (average progression rate 15%; P < 0.707). Lesions located in the anterior region of the lateral compartment showed less progression of cartilage degradation (6%; P < 0.001). No specific grade of lesion identified at baseline had a predilection for more rapid cartilage loss (P < 0.93).Conclusion. MRI can detect interval cartilage loss in patients over a short period (<2 years). The presence of meniscal and ACL tears was associated with more rapid cartilage loss. Cartilage lesions located in the central region of the medial compartment showed more rapid progression of cartilage loss than cartilage lesions in the anterior and posterior portions of the medial compartment. The findings in this study suggest that patients entering clinical trials investigating antiarthritis regimens may need to be randomized based on location of the lesion.

show abstract

“…T1 mapping of articular cartilage subsequent to injection and penetration of Gd(DTPA) 2-(Magnevist; Berlex Imaging, Wayne, NJ, USA) to assess the distribution of glycosaminoglycan (GAG) in articular cartilage (1). Previous implementations of dGEMRIC in vivo used timeconsuming single-slice two-dimensional (2D) imaging to obtain the data necessary for the T1 map (2-7).…”

Section: The Delayed Gadolinium-enhanced Mri Of Cartilage (Dgemric) Tmentioning

confidence: 99%

“…[1]) and custom-designed interface program code (13) (instructions are available at http:// radiology.bidmc.harvard.edu/research/cartilage/). The calculated T1(Gd) maps were then superimposed on one of the IR images for display purposes.…”

Section: T1 Calculationmentioning

confidence: 99%

Three‐dimensional delayed gadolinium‐enhanced MRI of cartilage (dGEMRIC) at 1.5T and 3.0T

McKenzie

Prasad

et al. 2006

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Purpose: To implement and validate a three-dimensional (3D) T1 measurement technique that is suitable for delayed gadolinium (Gd)-enhanced MRI of cartilage (dGEMRIC) and can be easily implemented with clinically available pulse sequences at 1.5T and 3.0T. Materials and Methods:A 3D inversion-recovery prepared spoiled gradient-echo (IR-SPGR) imaging pulse sequence with variable TR was used to implement a 3D T1 measurement protocol. The 3D T1 measurements were validated against a gold-standard single-slice 2D IR T1 measurement protocol in both phantoms and in vivo, in both asymptomatic volunteers and volunteers with osteoarthritis (OA).Results: T1 measurements in phantoms showed a statistically significant correlation between the 2D and 3D measurements at 1.5T (R 2 ϭ 0.993, P Ͻ 0.001) and 3.0T (R 2 ϭ 0.996, P Ͻ 0.001). In vivo application demonstrated the feasibility of using this 3D IR-SPGR sequence to evaluate the molecular status of articular cartilage throughout the knee joint with 0.63 ϫ 0.63 ϫ 3.0 mm spatial resolution within a 20-minute acquisition, even with the measurement parameters set for the higher T1(Gd) of cartilage at 3T (range ϭ 400 -900 msec mean T1 within a region of interest (ROI) in cartilage, compared to 200 -600 msec mean T1 at 1.5T). Conclusion:This 3D T1 measurement protocol may prove useful for the evaluation and follow-up of cartilage dGEM-RIC indices in clinical studies of OA.

show abstract

Nondestructive imaging of human cartilage glycosaminoglycan concentration by MRI

Cited by 533 publications

References 23 publications

In vivo quantification of human lumbar disc degeneration using T1ρ-weighted magnetic resonance imaging

In vivo quantification of human lumbar disc degeneration using T1ρ-weighted magnetic resonance imaging

Risk factors for progressive cartilage loss in the knee

Three‐dimensional delayed gadolinium‐enhanced MRI of cartilage (dGEMRIC) at 1.5T and 3.0T

Contact Info

Product

Resources

About