In vivo quantification of human lumbar disc degeneration using T1ρ-weighted magnetic resonance imaging

Auerbach, Joshua D.; Johannessen, Wade; Borthakur, Arijitt; Wheaton, Andrew J.; Dolinskas, Carol A.; Balderston, Richard A.; Reddy, Ravinder; Elliott, Dawn M.

doi:10.1007/s00586-006-0083-2

Cited by 106 publications

(96 citation statements)

References 43 publications

(41 reference statements)

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“…7) (R ¼ À0.51, p < 0.001) (34). From these data, it can be seen that compared with T 2 values in normal discs of $65 ms (29), T 1r at 1.5 T is longer than 100 ms (34). There are no data on field strength dependence and frequency dispersion for T 1r in intervertebral disc in the literature, but this work is clearly warranted.…”

Section: Mri Relaxation Time Measurementsmentioning

confidence: 81%

“…Quantitative T 1r imaging has been used in cartilage (31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41) and is affected by the interaction between motionally restricted water molecules and their macromolecular environment such as the glycosaminoglycan content. The extracellular matrix in the intervertebral disc may potentially be investigated using these techniques.…”

Section: Mri Relaxation Time Measurementsmentioning

confidence: 99%

“…In an in vivo study, at 1.5 T, with ten asymptomatic patients (40-60 years of age) with different grades of disc degeneration as assessed using T 2 weighted images and the Pfirrmann scale (14), Auerbach et al have shown that T 1r decreases with increasing degeneration (Fig. 7) (R ¼ À0.51, p < 0.001) (34). From these data, it can be seen that compared with T 2 values in normal discs of $65 ms (29), T 1r at 1.5 T is longer than 100 ms (34).…”

Section: Mri Relaxation Time Measurementsmentioning

confidence: 99%

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Magnetic resonance imaging and spectroscopy of the intervertebral disc

Majumdar

2006

NMR in Biomedicine

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Intervertebral disc disease is an emerging health concern and has a considerable negative effect on the economy and on society. MRI has a critical role in assessing the disc, but it is still a challenge to objectively correlate disc health and pain with images. In this paper, a review of MR disc imaging techniques including grading, relaxation time measurements, diffusion, and contrast perfusion is presented. In addition, high-resolution magic-angle spinning methods to correlate in vitro disc degeneration (with pain, etc) are discussed. With the potential for gaining morphological and biochemical information, MRI shows promise for quantitative assessment of disc health.

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Section: Mri Relaxation Time Measurementsmentioning

confidence: 81%

Section: Mri Relaxation Time Measurementsmentioning

confidence: 99%

Section: Mri Relaxation Time Measurementsmentioning

confidence: 99%

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Magnetic resonance imaging and spectroscopy of the intervertebral disc

Majumdar

2006

NMR in Biomedicine

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“…Qualitative grading of IVD degeneration is confined by subjective interpretation and limit degeneration classification to non-continuous grades. MRI sequences, enabling direct quantification of T1q and T2 relaxation time, have been developed and have showed promise for tissue characterization of the IVD [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

MRI histogram analysis enables objective and continuous classification of intervertebral disc degeneration

et al. 2017

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Purpose Magnetic resonance imaging (MRI) is the best diagnostic imaging method for low back pain. However, the technique is currently not utilized in its full capacity, often failing to depict painful intervertebral discs (IVDs), potentially due to the rough degeneration classification system used clinically today. MR image histograms, which reflect the IVD heterogeneity, may offer sensitive imaging biomarkers for IVD degeneration classification. This study investigates the feasibility of using histogram analysis as means of objective and continuous grading of IVD degeneration. Methods Forty-nine IVDs in ten low back pain patients (six males, 25-69 years) were examined with MRI (T2-weighted images and T2-maps). Each IVD was semi-automatically segmented on three mid-sagittal slices. Histogram features of the IVD were extracted from the defined regions of interest and correlated to Pfirrmann grade. Results Both T2-weighted images and T2-maps displayed similar histogram features. Histograms of well-hydrated IVDs displayed two separate peaks, representing annulus fibrosus and nucleus pulposus. Degenerated IVDs displayed decreased peak separation, where the separation was shown to correlate strongly with Pfirrmann grade (P \ 0.05). In addition, some degenerated IVDs within the same Pfirrmann grade displayed diametrically different histogram appearances. Conclusions Histogram features correlated well with IVD degeneration, suggesting that IVD histogram analysis is a suitable tool for objective and continuous IVD degeneration classification. As histogram analysis revealed IVD heterogeneity, it may be a clinical tool for characterization of regional IVD degeneration effects. To elucidate the usefulness of histogram analysis in patient management, IVD histogram features between asymptomatic and symptomatic individuals needs to be compared.

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“…Relaxation time constants have been demonstrated to be good predictors of disc water and glycosaminoglycan contents [8,9]; however, calculation of these surrogate magnetic resonance parameters requires comparatively long scan times and intensive post-processing. T2-weighted signal intensity measurements also correlate directly with disc water and glycosaminoglycan contents [10]; their application in a quantitative sense, however, is limited by the intrinsic magnetic field heterogeneities that exist within and between different MRI scanning platforms.…”

Section: Introductionmentioning

confidence: 99%

In vitro evaluation of a manganese chloride phantom-based MRI technique for quantitative determination of lumbar intervertebral disc composition and condition

et al. 2010

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The application of MRI as a non-invasive, quantitative tool for diagnosing lumbar intervertebral disc degeneration is currently an area of active research. The objective of this study was to examine, in vitro, the efficacy of a manganese chloride phantom-based MRI technique for quantitatively assessing lumbar disc composition and degenerative condition. Sixteen human lumbar discs were imaged ex vivo using T2-weighted MRI, and assigned a quantitative grade based on the relative signal intensities of nine phantoms containing serial concentrations of manganese chloride. Discs were then graded macroscopically for degenerative condition, and water and uronic acid (glycosaminoglycan) contents were determined. MRI ranking exhibited significant and strong negative correlation with nucleus pulposus uronic acid content (r = -0.78). MRI grades were significantly higher for degenerate discs. The technique described presents immediate potential for in vitro studies requiring robust, minimally invasive and quantitative determination of lumbar disc composition and condition.Additionally, the technique may have potential as a clinical tool for diagnosing lumbar disc degeneration as it provides a standardised series of reference phantoms facilitating crossplatform consistency, requires short scan times and simple T2-weighted signal intensity measurements.

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In vivo quantification of human lumbar disc degeneration using T1ρ-weighted magnetic resonance imaging

Cited by 106 publications

References 43 publications

Magnetic resonance imaging and spectroscopy of the intervertebral disc

Magnetic resonance imaging and spectroscopy of the intervertebral disc

MRI histogram analysis enables objective and continuous classification of intervertebral disc degeneration

In vitro evaluation of a manganese chloride phantom-based MRI technique for quantitative determination of lumbar intervertebral disc composition and condition

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