Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases

Maiti, Amit K.; Kim-Howard, Xana; Viswanathan, Parvathi; Guillén, Laura; Qian, Xiaoxia; Rojas-Villarraga, Adriana; Sun, Celi; Cañas, Carlos A.; Tobón, Gabriel J.; Matsuda, Koichi; Shen, Nan; Cherñavsky, Alejandra Claudia; Anaya, Juan Manuel; Nath, Swapan K.

doi:10.1093/rheumatology/kep470

Cited by 65 publications

(60 citation statements)

References 40 publications

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“…In previous studies, the rs763361 SNP in the CD226 gene has been reported to be associated with susceptibility to autoimmune diseases Douroudis et al, 2010;Maiti et al, 2010), including T1D in a Brazilian population (Mattana et al, 2014). Moreover, Lofgren et al (2010) identified the potential interference of the rs727088 SNP on the regulation of CD226 transcription both in T cells and natural killer cells.…”

Section: Discussionmentioning

confidence: 94%

“…Recently, several SNPs in the CD226 gene, such as rs763361 and rs727088, have been reportedly associated with several autoimmune diseases, including rheumatoid arthritis, systemic sclerosis, Graves' disease, systemic lupus erythematosus (SLE), and multiple sclerosis Douroudis et al, 2009;Maiti et al, 2010). The association of the rs763361 or rs727088 SNPs with T1D risk was also investigated in several studies.…”

Section: Introductionmentioning

confidence: 99%

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Association of CD226 polymorphisms with the susceptibility to type 1 diabetes in Chinese children

Nie

Wang

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Polymorphisms in the CD226 gene have been reported to be associated with autoimmune diseases. The aim of our study was to investigate the association between two single nucleotide polymorphisms (SNPs) (rs763361 and rs727088) in the CD226 gene and the risk for developing type 1 diabetes (T1D) in Chinese Han children. This case-control study included a total of 152 Chinese children with T1D and 304 matchedpair, healthy controls based on age and gender. The genetic variants of the rs763361 and rs727088 SNPs in the CD226 gene were determined using the polymerase chain reaction and restriction fragment length polymorphism method. The CD226 rs763361 polymorphism increased the risk of T1D in the genotype [P < 0.001, odds ratio (OR) = 3.9, 95% confidence interval (CI) = 2.24-6.76], dominant (P < 0.001, OR = 2.1, 95%CI = 1.40-3.14), and recessive (P < 0.001, OR = 0.5, 95%CI = 0.30-0.84) models. Additionally, the carriers of the T allele were more susceptible to T1D (P < 0.001, OR = 2.1, 95%CI = 1.58-2.79). Carriers of the T allele who were younger than 10 years of age at disease onset had an increased risk of T1D than those who were older at the disease onset. However, there was no association between the CD226 rs727088 SNP and risk for developing T1D. These findings revealed that CD226 rs763361 polymorphism was significantly associated with susceptibility to T1D and that the presence of the T allele might be a genetic factor for susceptibility to T1D.

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Association of CD226 polymorphisms with the susceptibility to type 1 diabetes in Chinese children

Nie

Wang

et al. 2015

Genet. Mol. Res.

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“…Four articles were excluded because 2 were review articles, 1 contained duplicate data, and 1 had no data concerning the polymorphisms. Thus, 19 studies met our inclusion criteria [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]. They consisted of 8 studies on the CTLA-4 polymorphism with 2093 patients and 2480 controls, 5 on the CD226 polymorphism with 2278 patients and 1940 controls, 6 on the FAS polymorphism with 546 patients and 618 controls, and 3 on the FASL polymorphism with 321 patients and 307 controls (Fig.…”

Section: Studies Included In the Meta-analysismentioning

confidence: 99%

“…While some studies have found that CTLA-4 rs5742909, CD226 rs763361, FAS-670 rs1800682, and FASL rs763110 polymorphisms are associated with RA, other studies have reported no such association [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]. To overcome the limitations of individual studies, resolve inconsistencies, and reduce the likelihood that random errors are responsible for false positive or false negative associations [32][33][34], we performed a meta-analysis to determine whether these polymorphisms are associated with RA susceptibility.…”

Section: Introductionmentioning

confidence: 99%

Association between the CTLA-4, CD226, FAS polymorphisms and rheumatoid arthritis susceptibility: A meta-analysis

2015

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“…This SNP has previously been reported to be associated with type 1 diabetes, MS, and RA in European Caucasian populations [5,7]. Moreover, during preparation of this manuscript, Maiti et al [15] published additional evidence supporting the role of the rs763361 SNP in primary Sjogren's syndrome (pSS), systemic lupus erythematosus, and RA in non-European Caucasians. In our study, we also included this published data for meta-analyses to examine diseasesspecific associations with CD226.…”

Section: Discussionmentioning

confidence: 72%

The CD226 gene in susceptibility of rheumatoid arthritis in the Chinese Han population

Shen

et al. 2011

Rheumatol Int

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Recent case-control studies have identified some loci that are associated with rheumatoid arthritis (RA). Among these, a single nucleotide polymorphism (SNP), Gly307Ser (rs763361), in the CD226 gene was first discovered to confer the risk of RA in populations with European and Colombian ancestry. Because the effect of genetic factors varies in different races, the association between RA and CD226 is yet to be evaluated in other non-European populations. Here, we report the significant association between CD226 and RA in a Chinese population of 423 randomly enrolled individuals. The statistical results show that the rs763361 SNP in the CD226 gene is significantly associated with RA in the Chinese population group (P (obs) = 0.005, odds ratio = 1.52). After adjusting for sex and age using multivariate logistics regression analysis, the association is still positive (P (adj) = 0.029, odds ratio = 1.45). Meta-analysis confirms the association between rs763361 and RA (overall P < 0.001, overall odds ratio = 1.12). The test of odds ratio heterogeneity also suggests that the rs763361 SNP confers the same risk of RA in both the Chinese and the Colombian populations, and indicates that rs763361 may play a more important role in non-European populations compared with the European population (P = 0.031). These results demonstrate a genetic association between the CD226 gene and RA in a Chinese Han population with a potentially greater genetic effect than in the European population.

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Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases

Abstract: Our results demonstrate that the coding variant rs763361 in CD226 gene is associated with multiple ADs in non-European populations.

Cited by 65 publications

References 40 publications

Association of CD226 polymorphisms with the susceptibility to type 1 diabetes in Chinese children

Association of CD226 polymorphisms with the susceptibility to type 1 diabetes in Chinese children

Association between the CTLA-4, CD226, FAS polymorphisms and rheumatoid arthritis susceptibility: A meta-analysis

The CD226 gene in susceptibility of rheumatoid arthritis in the Chinese Han population

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