Abstract:Nonsteroidal anti-inflammatory drugs, or NSAIDs, are among the most often prescribed pain relievers. NSAIDs are a highly successful medicine class for pain and inflammation, but they are also known to cause gastrointestinal bleeding, cardiovascular side effects, and NSAID-induced nephrotoxicity. The pharmacodynamic action of these medicines is predominantly mediated by COX2 inhibition, whereas COX1 inhibition is largely responsible for the unfavourable effects. The activity of (COX-1) and COX2, and thus the sy… Show more
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