Non-steroidal Anti Inflammatory Drugs and Gastrointestinal Toxicity

Mehta, Divij; Dk, Bhargava

doi:10.1016/s0976-0016(12)60018-0

Cited by 14 publications

(12 citation statements)

References 70 publications

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“…In recent years, a shift towards natural therapy has been observed and there is less interest in synthetic drugs, such as non‐steroidal anti‐inflammatory drugs (NSAIDs), due to reported adverse complications . Clinacanthus nutans (Burm.…”

Section: Introductionmentioning

confidence: 99%

¹H‐NMR metabolomics for evaluating the protective effect of Clinacanthus nutans (Burm. f) Lindau water extract against nitric oxide production in LPS‐IFN‐γ activated RAW 264.7 macrophages

Khoo

Kow

Maulidiani

et al. 2018

Phytochemical Analysis

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Section: Introductionmentioning

confidence: 99%

¹H‐NMR metabolomics for evaluating the protective effect of Clinacanthus nutans (Burm. f) Lindau water extract against nitric oxide production in LPS‐IFN‐γ activated RAW 264.7 macrophages

Khoo

Kow

Maulidiani

et al. 2018

Phytochemical Analysis

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“…Email: rebecca_ng_2000@yahoo.com ibuprofen and indomethacin, are used to treat inflammation. However, the use of these synthetic drugs to treat inflammation can cause severe gastrointestinal and cardiovascular complications (Mehta & Bhargava 2010;Sostres et al 2010). Thus, there is still a need for the discovery of new anti-inflammatory drugs with fewer or no side-effects.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of nitric oxide production by Solanum melongena and Solanum macrocarpon on RAW 264.7 cells

Yiin

Abidin

Shuib

et al. 2015

Frontiers in Life Science

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Nitric oxide (NO) plays an important role in the physiology and pathophysiology of disease. Overproduction of NO is associated with chronic inflammatory diseases and cancers. Several species of Solanaceae have been used traditionally to treat inflammatory-related diseases. To analyse the possible anti-inflammatory properties of these species, the Griess assay was used to evaluate the effects of various Solanum melongena and Solanum macrocarpon extracts on NO production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. The cytotoxicity of the extracts on the cell line was tested using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Extracts that significantly inhibited NO production were further evaluated for inducible nitric oxide synthase (iNOS) expression by Western blot. Thin-layer chromatography was used to determine the major compounds in the extracts. All extracts significantly inhibited NO production in LPS-stimulated RAW 264.7 cells in a dose-dependent manner. At 200 μg/ml, ethyl acetate extract of S. macrocarpon showed the highest NO inhibition of 81%, with a median inhibitory concentration (IC 50 ) value of 44.78 ± 0.04 μg/ml. The viability of cells treated with the extracts was greater than 80%. Ethanol and ethyl acetate extracts of S. melongena, together with ethanol, hexane and ethyl acetate extracts of S. macrocarpon, reduced iNOS expression significantly. At 200 μg/ml, ethyl acetate extract of S. macrocarpon inhibited iNOS protein expression by 79%. Phytochemical analysis of the extracts showed that fluorescent, double-bond compounds, phenols, flavonoids and terpenoids were mainly present in the extracts. Taken together, the results show the potential of ethanol and ethyl acetate extracts of S. melongena, and hexane and ethyl acetate extracts of S. macrocarpon, as agents for the prevention and treatment of inflammatory-related diseases.

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“…Patients with increased sensitivity to NSAIDs or those who make a long-term use of high doses of NSAIDs usually show more severe lesions that can result in ulcers, bleeding and sometimes perforations, often aggravated by platelet inhibition due to reduced TXA2 production from PGH2 as a result of COX-1 inhibition (reviewed in [36]). …”

Section: Nsaids Toxicitymentioning

confidence: 99%

Endoplasmic reticulum stress response in the roadway for the effects of non-steroidal anti-inflammatory drugs

Mügge

Silva

2015

Endoplasmic Reticulum Stress in Diseases

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Over the past decade, a handful of evidence has been provided that nonsteroidal anti-inflammatory drugs (NSAIDs) display effects on the homeostasis of the endoplasmic reticulum (ER). Their uptake into cells will eventually lead to activation or inhibition of key molecules that mediate ER stress responses, raising not only a growing interest for a pharmacological target in ER stress responses but also important questions how the ER-stress mediated effects induced by NSAIDs could be therapeutically advantageous or not. We review here the toxicity effects and therapeutic applications of NSAIDs involving the three majors ER stress arms namely PERK, IRE1, and ATF6. First, we provide brief introduction on the well-established and characterized downstream events mediated by these ER stress players, followed by presentation of the NSAIDs compounds and mode of action, and finally their effects on ER stress response. NSAIDs present promising drug agents targeting the components of ER stress in different aspects of cancer and other diseases, but a better comprehension of the mechanisms underlying their benefits and harms will certainly pave the road for several diseases’ therapy.

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Non-steroidal Anti Inflammatory Drugs and Gastrointestinal Toxicity

Cited by 14 publications

References 70 publications

¹H‐NMR metabolomics for evaluating the protective effect of Clinacanthus nutans (Burm. f) Lindau water extract against nitric oxide production in LPS‐IFN‐γ activated RAW 264.7 macrophages

¹H‐NMR metabolomics for evaluating the protective effect of Clinacanthus nutans (Burm. f) Lindau water extract against nitric oxide production in LPS‐IFN‐γ activated RAW 264.7 macrophages

Inhibition of nitric oxide production by Solanum melongena and Solanum macrocarpon on RAW 264.7 cells

Endoplasmic reticulum stress response in the roadway for the effects of non-steroidal anti-inflammatory drugs

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Non-steroidal Anti Inflammatory Drugs and Gastrointestinal Toxicity

Cited by 14 publications

References 70 publications

1H‐NMR metabolomics for evaluating the protective effect of Clinacanthus nutans (Burm. f) Lindau water extract against nitric oxide production in LPS‐IFN‐γ activated RAW 264.7 macrophages

1H‐NMR metabolomics for evaluating the protective effect of Clinacanthus nutans (Burm. f) Lindau water extract against nitric oxide production in LPS‐IFN‐γ activated RAW 264.7 macrophages

Inhibition of nitric oxide production by Solanum melongena and Solanum macrocarpon on RAW 264.7 cells

Endoplasmic reticulum stress response in the roadway for the effects of non-steroidal anti-inflammatory drugs

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¹H‐NMR metabolomics for evaluating the protective effect of Clinacanthus nutans (Burm. f) Lindau water extract against nitric oxide production in LPS‐IFN‐γ activated RAW 264.7 macrophages

¹H‐NMR metabolomics for evaluating the protective effect of Clinacanthus nutans (Burm. f) Lindau water extract against nitric oxide production in LPS‐IFN‐γ activated RAW 264.7 macrophages