Non-metallothionein-bound cadmium in the pathogenesis of cadmium nephrotoxicity in the rat

Goyer, Robert A.; Miller, Chris R.; Zhu, Su‐Li; Victery, Winona

doi:10.1016/0041-008x(89)90272-x

Cited by 112 publications

(67 citation statements)

References 32 publications

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“…Light microscopy shows focal areas of necrosis and interstitial fibrosis within the renal cortex. These findings are associated with renal Cd levels (22). With increasing Cd doses, the size of nuclei and nucleoli in the cells of the proximal tubule shows significant enlargement and also an increase in the number of nucleoli on light microscopy.…”

Section: Discussionmentioning

confidence: 67%

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Protective Effect of Quercetin Against Renal Toxicity Induced by Cadmium in Rats

Aktoz¹

2012

Balkan Med J

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Objective: The aim of the present study was to examine the protective effect of quercetine (QE) against cadmium (Cd)-induced renal toxicity. Material and Methods:A total of 24 male Wistar albino rats were divided into three groups: control, Cd-treated and Cd-treated with QE; each group containing 8 animals. The Cd-treated group was injected subcutaneously with CdCl2 dissolved in saline in the dose of 2 ml/kg/day for 30 days, resulting in a dosage of 1 mg/kg Cd. The rats in the QE treated groups were given QE (15 mg/kg body weight) once a day intraperitoneally starting 2 days prior to Cd injection during the study period.Results: The renal histology in Cd-treated rats showed mesangial expansion, thickening of capsular basement membranes, glomerular basement membranes and tubular basement membranes, characterized by an increase in periodic acid Schiff (PAS)-positive areas as compared with control animals. With the QE treatment, despite the presence of only a few swollen glomeruli, we noticed a marked protection of renal structure when compared with the Cd-treated rats. Furthermore, QE pretreatment resulted in increased proliferating cell nuclear antigen (PCNA) immunoreactivity and decreased the activity of Terminal Transferase dUTP Nick End Labeling (TUNEL). Conclusion:These findings suggest that QE may attenuate Cd-induced renal toxicity.

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Section: Discussionmentioning

confidence: 67%

“…High levels of Cd are clearly capable of causing proximal tubule necrosis (22,24). However, other studies indicate that the early stages of Cd nephrotoxicity primarily involve apoptosis of proximal tubule epithelial cells, with little evidence of necrosis (25,26).…”

mentioning

confidence: 97%

Protective Effect of Quercetin Against Renal Toxicity Induced by Cadmium in Rats

Aktoz¹

2012

Balkan Med J

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“…Exposure to toxins such as cadmium and lead, which cause tubular dysfunction and chronic interstitial nephritis in exposed humans and rodents (24,(28)(29)(30)(31)(32), is typically chronic and sustained. Such circumstances could provoke prolonged HSP70 expression, and allow autoreactive, HSP70-specific T cells to expand in number and mediate injury.…”

Section: Discussionmentioning

confidence: 99%

“…Rats chronically administered CdCh demonstrate tubular epithelial swelling and patchy necrosis at 4-6 wk, with early interstitial infiltrates seen at 8 wk (24). We first examined the time course of disease development for CdCh-induced interstitial nephritis in SJL/J mice.…”

Section: Sjl Mice Treated With Cdci~ Express Hsp70 In Their Kidneys Bmentioning

confidence: 99%

T cells reactive to an inducible heat shock protein induce disease in toxin-induced interstitial nephritis.

Weiss

Madaio

Tomaszewski

et al. 1994

The Journal of Experimental Medicine

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SummaryT cells reactive against immunodominant regions of inducible heat shock proteins (HSPs) have been identified in the chronic inflammatory lesions of several experimental autoimmune diseases. Since HSPs are known to be induced by a number of renal tubular epithelial cell toxins associated with chronic interstitial nephritis, we investigated the relevance of HSP expression and T cell reactivity to HSP70 in a model of progressive inflammatory interstitial nephritis. Chronic administration of cadmium chloride (CdClz) to SJL/J mice induces HSP70 expression in renal tubular cells 4-5 wk before the development of interstitial mononuclear cell infiltrates. CdC12 also induces HSP70 expression in cultured tubular epithelial cells from SJL/J mice. CD4 +, TCR-od~ + T cell lines specific for an immunodominant HSP peptide are cytotoxic to heat stressed or CdClz-treated renal tubular cells. Such HSP-reactive T cells mediate an inflammatory interstitial nephritis after adoptive transfer to CdClz-treated mice at a time when immunoreactive HSPT0 is detectable in the kidneys, but before the development of interstitial mononuclear cell infiltrates. T cells isolated from the nephritic kidneys of mice treated with CdC12 for 13 wk are also cytotoxic to heat shocked or cadmium-treated tubular cells. These kidney-derived T cells additionally induced interstitial nephritis after passive transfer, indicating their pathogenic significance. Our studies strongly support a role for HSP-reactive T ceils in CdC12-induced interstitial nephritis and suggest that the induction of HSPs in the kidney by a multitude of "nonimmune" events may initiate or facilitate inflammatory damage by HSP-reactive lymphocytes.

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“…The most typical feature of chronic cadmium exposure is renal glomerular and tubular damage (Goyer 1989). Copper, unlike cadmium and lead is a common component of some biological fluids and essential for certain biological activity, but it becomes toxic when present in high concentrations as a result of bioaccumulation (Abdulrahman & Tsafe 2004).…”

Section: Introductionmentioning

confidence: 99%

Assessment of levels of copper, cadmium and lead in secretion of mammary gland of cows grazed on open fields

Lawal

Mohammed

Damisa

2010

Science World Journal

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The levels of copper, cadmium and lead were determined in milk samples from cows grazed on open fields. The use of H2O2 cleared the residual colours of the metal solutions following digestion with HNO3 acid. The results of the Atomic Absorption Spectrophotometric analysis of the metal solutions from the milk samples showed the metal concentrations in the order Pb (0.531±0.299 mg/dm 3 )>Cd (0.257±0.127 mg/dm 3 )>Cu (0.062±0.026 mg/dm 3 ). The levels of Pb and Cd in the milk samples studied exceeded the permissible maximum daily intake recommended by W.H.O. in the health criteria.

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Non-metallothionein-bound cadmium in the pathogenesis of cadmium nephrotoxicity in the rat

Cited by 112 publications

References 32 publications

Protective Effect of Quercetin Against Renal Toxicity Induced by Cadmium in Rats

Protective Effect of Quercetin Against Renal Toxicity Induced by Cadmium in Rats

T cells reactive to an inducible heat shock protein induce disease in toxin-induced interstitial nephritis.

Assessment of levels of copper, cadmium and lead in secretion of mammary gland of cows grazed on open fields

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