Protective Effect of Quercetin Against Renal Toxicity Induced by Cadmium in Rats

Abstract

Objective: The aim of the present study was to examine the protective effect of quercetine (QE) against cadmium (Cd)-induced renal toxicity. Material and Methods:A total of 24 male Wistar albino rats were divided into three groups: control, Cd-treated and Cd-treated with QE; each group containing 8 animals. The Cd-treated group was injected subcutaneously with CdCl2 dissolved in saline in the dose of 2 ml/kg/day for 30 days, resulting in a dosage of 1 mg/kg Cd. The rats in the QE treated groups were given QE (15 mg/kg body weight) once a day intraperitoneally starting 2 days prior to Cd injection during the study period.Results: The renal histology in Cd-treated rats showed mesangial expansion, thickening of capsular basement membranes, glomerular basement membranes and tubular basement membranes, characterized by an increase in periodic acid Schiff (PAS)-positive areas as compared with control animals. With the QE treatment, despite the presence of only a few swollen glomeruli, we noticed a marked protection of renal structure when compared with the Cd-treated rats. Furthermore, QE pretreatment resulted in increased proliferating cell nuclear antigen (PCNA) immunoreactivity and decreased the activity of Terminal Transferase dUTP Nick End Labeling (TUNEL). Conclusion:These findings suggest that QE may attenuate Cd-induced renal toxicity.

Protective Potential of Quercetin on Cd-Induced Hepatorenal Damage

“…2e). A similar result was obtained by [13,51]. On the other hand, glomular parts exhibited minimal histologic changes (Fig.…”

Thymoquinone Ameliorates Cadmium-Induced Nephrotoxicity, Apoptosis, and Oxidative Stress in Rats is Based on its Anti-Apoptotic and Anti-Oxidant Properties

“…Thus, since apoptosis may be one of the main features of Cd intoxication, it seems necessary to conduct more effective studies on the phenomenon in the tubular epithelium after exposure to higher doses of Cd. Exposure to Cd has been shown to induce apoptosis of the proximal tubular cells and, therefore, disrupt kidney function [18,39,41,42]. Yuan et al [43] confirmed that Cd disrupted apoptosis in the kidneys.…”

“…The administration of Cd resulted in various damages to the proximal tubules and glomeruli of the kidneys. Quercetin, an anti-oxidant substance, was shown to reverse this damage [18]. In 2011, Fouad and Jresat administered mice with 1.2 mg Cd for 9 weeks.…”

“…Control animals received daily injections of the saline vehicle alone. The Cd-treated group was injected subcutaneously with CdCl2 dissolved in saline in the amount of 2 ml/kg/day for 30 days, resulting in a dosage of 1 mg/kg Cd [18]. The rats in the TQ-treated group were given TQ (50 mg/kg body weight) [13] once a day orally together with first Cd injection during the study period.…”

Effect of Cadmium on Trophoblast Cell Proliferation and Apoptosis in Different Gestation Periods of Rat Placenta

“…Important Cd sources affecting human life are cigarette smoke, refined nutrients, water pipes, coffee, tea, products released by burning coal, shellfishes, fertilizers used, dyes and batteries containing Cd, and flue gases released in industrial production stages [7]. Occupational and environmental Cd exposure cause serious damages in the tissues like the placenta, kidney, liver, testis, heart, brain, and lungs [8][9][10][11][12][13][14][15]. Several investigations confirmed its transport across the placenta and accumulation in fetuses [16,17].…”