Non-Invasive Spectroscopic Determination of the Antioxidative Status of Gravidae and Neonates

Lademann, Hanne; Gerber, Bernd; Olbertz, Dirk; Darvin, Maxim E.; Stauf, Leonie; Ueberholz, Kirsten; Heinrich, Verena; Lademann, Jürgen; Briese, Volker

doi:10.1159/000365520

Cited by 11 publications

(9 citation statements)

References 45 publications

(57 reference statements)

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“…The skin is confronted with ROS and other free radicals on a daily basis; whereby, the main noxa is solar radiation but also smoking, alcohol consumption and physical and psychological stress lead to the formation of ROS and free radicals in the skin-known as oxidative stress [2]. Oxidative stress promotes the damage of cell components by ROS such as hydrogen peroxide (H2O2), hydroxyl radicals (OH•) or superoxide radicals (O2•) [2][3][4]. Antioxidants as free radical scavengers can protect cells against the consequences of oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Determination of the Antioxidant Status of the Skin by In Vivo-Electron Paramagnetic Resonance (EPR) Spectroscopy

et al. 2015

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Organisms produce free radicals which are essential for various metabolic processes (enzymatic oxidation, cellular respiration, signaling). Antioxidants are important chemical compounds that specifically prevent the oxidation of substances by scavenging radicals, especially reactive oxygen species (ROS). Made up of one or two unpaired electrons, ROS are free radicals that are highly reactive and can attack other metabolites. By using electron paramagnetic resonance (EPR) spectroscopy, it is possible to measure paramagnetic substances such as free radicals. Therefore the dermal antioxidant activity can be determined by applying semi-stable radicals onto the skin and measuring the antioxidant-induced radical scavenging activity in the skin. In recent years, EPR has been OPEN ACCESS Cosmetics 2015, 2 287 developed as a spectroscopic method for determining the antioxidant status in vivo. Several studies have shown that an additional uptake of dietary supplements, such as carotenoids or vitamin C in physiological concentrations, provide a protective effect against free radicals. Using the EPR technique it could be demonstrated that the radical production in stress situations, such as irradiation with infrared and visible light, was reduced with time. However, not only the oral uptake of antioxidants, but also the topical application of antioxidants, e.g., a hyperforin-rich cream, is very useful against the development of oxidative stress. Regular application of a hyperforin-rich cream reduced radical formation. The skin lipids, which are very important for the barrier function of the skin, were also stabilized.

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Section: Introductionmentioning

confidence: 99%

Determination of the Antioxidant Status of the Skin by In Vivo-Electron Paramagnetic Resonance (EPR) Spectroscopy

et al. 2015

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“…Even though it was beyond the scope of this study, the possible role of additional factors such as carotenoid antioxidants and the time course of their depletion from a potential reservoir in an infant’s subcutaneous fatty tissue could provide valuable insights into the skin’s ability to compensate for nutritional deficiencies [26]. Carotenoids are known to play a key protective role in the skin against the increased formation of free radicals associated with system stress; term newborns have maximal levels which decrease over time and are directly related to nutritional conditions [26].…”

Section: Resultsmentioning

confidence: 99%

“…Carotenoids are known to play a key protective role in the skin against the increased formation of free radicals associated with system stress; term newborns have maximal levels which decrease over time and are directly related to nutritional conditions [26]. …”

Section: Resultsmentioning

confidence: 99%

Comparison of Skin Structural and Functional Parameters in Well-Nourished and Moderately Undernourished Infants

Hughes-Formella¹,

Wunderlich²,

Williams³

et al. 2019

Skin Pharmacol Physiol

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Background: Little is known about the impact of nutrition on the development of skin structure and function in infants. Methods: We investigated epidermal, dermal, and subcutis parameters of aged-matched well-nourished and moderately undernourished infants in this single-center, cross-sectional, noninterventional study using noninvasive methods (skin caliper, 20-MHz sonography, transepidermal water loss, skin pH, and corneometry). Plasma fatty acids were determined as an indicator of nutritional differences. 310 infants from different age groups, i.e., 1 week, 4 weeks, and 6, 9, 12, 24, and 36 months were included. Approximately half of each age group was well-nourished (WHO reference values weight-for-height/length Zscore: –0.75 ≤ Z ≤ 0.75) and the other half was moderately undernourished (–3 ≤ Z < –2). Results: Structural maturational differences in the deeper dermis and subcutis regions of the skin and subtle functional changes in the epidermis were observed in moderately undernourished infants without notable clinical symptoms. Reduced skin barrier function or skin hydration were not observed in the undernourished infants, and skin pH shifted to more acidic values in this group. Conclusion: These findings reveal a greater impact of moderate undernutrition on the development of the dermis and subcutis and suggest that critical epidermal functions such as skin barrier and pH are mostly maintained.

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“…Free radicals from surrounding environment and inside‐out constantly interact with the human epidermis and induce oxidative stress interfering with the organism's homeostasis 10,11 . Human skin contains carotenoids that provide the antioxidant defense to the living epidermal cells by inactivating and transforming free radicals.…”

Section: Introductionmentioning

confidence: 99%

Epidermal carotenoid levels in vivo of patients with plaque psoriasis: Effects of narrow‐band UVB phototherapy

Darlenski

Deliyska

Al-Sadek

et al. 2020

Photoderm Photoimm Photomed

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Background Psoriasis is a systemic inflammatory disease characterized by hindered antioxidant defense and increased formation of free radicals. There are limited data on the skin carotenoids in psoriatic skin as well as their modulation during narrow‐band UVB (NB‐UVB) phototherapy of the disease. Aim The aim of this prospective study is to reveal the skin carotenoids levels during NB‐UVB phototherapy of psoriasis in humans. Material and methods Twenty Caucasian subjects with mild‐to‐moderate plaque psoriasis (15m; 5f) were enrolled in the study, and nine gender‐ and age‐matched healthy volunteers were recruited for controls of oxidative stress measurements. All psoriasis patients underwent 10 sessions of NB‐UVB phototherapy. Measurements were taken at baseline and after 10 sessions of NB‐UVB phototherapy. The assessment of carotenoid levels in the skin in vivo was performed by a non‐invasive, reflectance spectroscopy‐based device. Psoriasis severity was assessed by psoriasis area and severity index (PASI). The dermatology life quality index (DLQI) was evaluated in psoriatic patients. Results Baseline carotenoid levels were significantly lower in psoriasis patients in comparison to healthy controls. NB‐UVB phototherapy insignificantly diminished carotenoid levels in the skin of psoriasis patients, while clinical improvement both in PASI score and DLQI was observed. Conclusion We showed the levels of skin carotenoids in psoriatic patients are lower than in healthy subjects. NB‐UVB did not change significantly skin carotenoid levels. Further studies should elucidate the potential effect of antioxidants supplementation during NB‐UVB of psoriasis.

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Non-Invasive Spectroscopic Determination of the Antioxidative Status of Gravidae and Neonates

Cited by 11 publications

References 45 publications

Determination of the Antioxidant Status of the Skin by In Vivo-Electron Paramagnetic Resonance (EPR) Spectroscopy

Determination of the Antioxidant Status of the Skin by In Vivo-Electron Paramagnetic Resonance (EPR) Spectroscopy

Comparison of Skin Structural and Functional Parameters in Well-Nourished and Moderately Undernourished Infants

Epidermal carotenoid levels in vivo of patients with plaque psoriasis: Effects of narrow‐band UVB phototherapy

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