Comparison of Skin Structural and Functional Parameters in Well-Nourished and Moderately Undernourished Infants

Hughes-Formella, Betsy; Wunderlich, Oliver; Williams, Ragna; Fernández, Josefina; Kim, Yun Zyong; Wigger‐Alberti, W.; Pecquet, Sophie; Moodycliffe, Angus M.

doi:10.1159/000499434

Cited by 3 publications

(11 citation statements)

References 25 publications

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“…22 The mean values, though, for undernourished children all were within normal range. 22 Palma et al 23 looked at daily water consumption and its impact on TEWL values in 49 healthy female volunteers aged 22-34. They split the participants into two groups; group one consisted of participants who consumed <3200 ml day −1 of water over the past 4 weeks (n = 38) and group two >3200 ml day −1 (n = 11).…”

Section: Nutritional and Hydration Statusmentioning

confidence: 77%

“…Nutritional and hydration status may also impact TEWL values in developing and developed skin. Hughes‐Formella et al 22 used a noninterventional study to match under‐nourished infants, children with a weight/height ratio between a Z score of −2 and −3, to well‐nourished infants having a weight/height ratio between a Z score of −0.75 and 0.75. The 310 participants were put in seven groups by age ranging from 4 weeks ±7 days to 36 months ±84 days 22 .…”

Section: Resultsmentioning

confidence: 99%

“…Nutritional and hydration status may also impact TEWL values in developing and developed skin. Hughes-Formella et al 22…”

Section: Nutritional and Hydration Statusmentioning

confidence: 99%

“…In this cohort, undernourished infants had lower contribution levels of linolenic acid that plays a role in barrier function, possibly suggesting how nutrition may influence TEWL values in infants. 22 Similarly, friction and scratching cause physical damage to skin barrier function, increasing TEWL. 46 Stress within individuals also leads to increased TEWL values.…”

Section: Miteva Et Al (2006) Put Forth Recommendations To Optimize Ca...mentioning

confidence: 99%

See 3 more Smart Citations

“Normal” TEWL‐how can it be defined? A systematic review

Green

Feschuk

Kashetsky

et al. 2022

Experimental Dermatology

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An optimal amount of water, especially in the stratum corneum, is essential for maintaining normal functioning, healthy skin. 1 Therefore, the amount of water from the skin is carefully regulated, in part through trans-epidermal water loss. 1 Trans-epidermal water loss (TEWL) is an objective measurement of the amount of water passively evaporating from a designated area of stratum corneum in a fixed amount of time due to the water vapour pressure gradient on either side of the skin. It has historically been used as a measure of barrier water function and skin integrity in healthy individuals. 2 Advantages of using a non-invasive marker of skin integrity such as TEWL include a lack of skin barrier destruction, and the potential for early detection of subclinical effects. 3 Elevated TEWL values may reflect barrier dysfunction in diseases such as atopic dermatitis and psoriasis. 4,5 Oppositely, decreased TEWL values reflect an intact or recovered dermal barrier. 5 Thus, TEWL values are typically measured for in vitro permeation testing (IVPT) to reflect a healthy skin sample, and regulatory agencies such as the Food and Drug Administration (FDA) and European Group for Efficacy

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Section: Nutritional and Hydration Statusmentioning

confidence: 77%

Section: Resultsmentioning

confidence: 99%

“…Nutritional and hydration status may also impact TEWL values in developing and developed skin. Hughes-Formella et al 22…”

Section: Nutritional and Hydration Statusmentioning

confidence: 99%

Section: Miteva Et Al (2006) Put Forth Recommendations To Optimize Ca...mentioning

confidence: 99%

See 2 more Smart Citations

“Normal” TEWL‐how can it be defined? A systematic review

Green

Feschuk

Kashetsky

et al. 2022

Experimental Dermatology

View full text Add to dashboard Cite

show abstract

“…Transepidermal water loss (TEWL) measurements indicate that after the first month after birth, TEWL seems to become similar to the adult skin [ 10 , 12 , 13 ]. Until one year of age, TEWL increases [ 10 , 14 , 15 ], and pH values of the skin surface decline from immediately after birth to several months later, indicating skin barrier maturation [ 10 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Interrelationships between Skin Structure, Function, and Microbiome of Pregnant Females and Their Newborns: Study Protocol for a Prospective Cohort Study

Wilborn

Kottner

Hillmann

et al. 2021

Dermatology Research and Practice

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Background. Pregnancy leads to several skin changes, but evidence about structural and functional skin changes is scarce. Findings on skin structure and function in children in their first year reveal rapid skin maturation, but evidence indicates that in particular, water holding and transport mechanisms are different from adults. Important questions include whether maternal cutaneous properties predict infant skin condition, and if so, how. This is especially relevant for the skin’s microbiome because it closely interacts with the host and is assumed to play a role in many skin diseases. Therefore, the study objective is to explore characteristics of skin and hair of pregnant women and their newborns during pregnancy and in the first six months after delivery and their associations. Methods. The study has an observational longitudinal design. We are recruiting pregnant females between 18 and 45 years using advertisement campaigns in waiting areas of gynecologists and hospital’s outpatient services. A final sample size of n = 100 women is the target. We perform noninvasive, standardized skin, hair, and skin microbiome measurements. We establish the baseline visit during pregnancy until at the latest four weeks before delivery. We schedule follow-up visits four weeks and six months after birth for mothers and their newborns. We will calculate descriptive statistical methods using frequencies and associations over time depending on scale levels of the measurements. Discussion. The majority of previous studies that have investigated infants’ skin microbiome and its associations used cross-sectional designs and focused on selected characteristics in small samples. In our longitudinal study, we will characterize a broad range of individual and environmental characteristics of mothers and their newborns to evaluate interrelationships with skin parameters and their changes over time. Considering the combination of these multiple variables and levels will allow for a deeper understanding of the complex interrelationship of the newborn’s skin maturation. This trial is registered with ClinicalTrials.gov (Identifier: NCT04759924).

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Development and Evaluation of an In Silico Dermal Absorption Model Relevant for Children

et al. 2022

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The higher skin surface area to body weight ratio in children and the prematurity of skin in neonates may lead to higher chemical exposure as compared to adults. The objectives of this study were: (i) to provide a comprehensive review of the age-dependent anatomical and physiological changes in pediatric skin, and (ii) to construct and evaluate an age-dependent pediatric dermal absorption model. A comprehensive review was conducted to gather data quantifying the differences in the anatomy and physiology of child and adult skin. Maturation functions were developed for model parameters that were found to be age-dependent. A pediatric dermal absorption model was constructed by updating a MoBi implementation of the Dancik et al. 2013 skin permeation model with these maturation functions. Using a workflow for adult-to-child model extrapolation, the predictive performance of the model was evaluated by comparing its predicted rates of flux of diamorphine, phenobarbital and buprenorphine against experimental observations using neonatal skin. For diamorphine and phenobarbital, the model provided reasonable predictions. The ratios of predicted:observed flux in neonates for diamorphine ranged from 0.55 to 1.40. For phenobarbital, the ratios ranged from 0.93 to 1.26. For buprenorphine, the model showed acceptable predictive performance. Overall, the physiologically based pediatric dermal absorption model demonstrated satisfactory prediction accuracy. The prediction of dermal absorption in neonates using a model-based approach will be useful for both drug development and human health risk assessment.

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Comparison of Skin Structural and Functional Parameters in Well-Nourished and Moderately Undernourished Infants

Cited by 3 publications

References 25 publications

“Normal” TEWL‐how can it be defined? A systematic review

“Normal” TEWL‐how can it be defined? A systematic review

Interrelationships between Skin Structure, Function, and Microbiome of Pregnant Females and Their Newborns: Study Protocol for a Prospective Cohort Study

Development and Evaluation of an In Silico Dermal Absorption Model Relevant for Children

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